2020
DOI: 10.21203/rs.2.18159/v2
|View full text |Cite
Preprint
|
Sign up to set email alerts
|

Production of an anti-angiogenic factor sFLT1 is suppressed via promoter hypermethylation of FLT1 gene in choriocarcinoma cells

Abstract: Background: Soluble Fms-like tyrosine kinase-1 (sFLT1) as an anti-angiogenic factor is abundantly expressed in placental trophoblasts. Choriocarcinoma, a malignant tumor derived from trophoblasts, is known to be highly angiogenic and metastatic. However, the molecular mechanism underlying angiogenesis in choriocarcinoma pathogenesis remains unclear. We aimed to investigate the mRNA expression and DNA methylation status of the FLT1 gene in human choriocarcinoma cells and trophoblast cells. Methods: qRT-PCR, Wes… Show more

Help me understand this report
View published versions

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1

Citation Types

0
2
0

Year Published

2020
2020
2020
2020

Publication Types

Select...
1

Relationship

0
1

Authors

Journals

citations
Cited by 1 publication
(2 citation statements)
references
References 26 publications
0
2
0
Order By: Relevance
“…Contrary to preeclampsia, choriocarcinoma is vastly angiogenic and produces high levels of PlGF to promote the development of blood vessels [ 20 ]. Remarkably, although choriocarcinoma is part of a spectrum of conditions known as gestational trophoblastic disease: complete and partial hydatidiform mole, invasive mole, choriocarcinoma and placental-site trophoblastic tumor, they show different pattern of angiogenesis expression, for example, while molar gestations produce more anti-angiogenic proteins similar to preeclampsia [ 46 ], expression of sFlt-1 is strongly suppressed in choriocarcinoma cell lines and VEGF is highly expressed in these cells [ 47 ]. Indeed, choriocarcinoma can even be developed in males, and therefore not related to the increased in preeclampsia as molar gestations do.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Contrary to preeclampsia, choriocarcinoma is vastly angiogenic and produces high levels of PlGF to promote the development of blood vessels [ 20 ]. Remarkably, although choriocarcinoma is part of a spectrum of conditions known as gestational trophoblastic disease: complete and partial hydatidiform mole, invasive mole, choriocarcinoma and placental-site trophoblastic tumor, they show different pattern of angiogenesis expression, for example, while molar gestations produce more anti-angiogenic proteins similar to preeclampsia [ 46 ], expression of sFlt-1 is strongly suppressed in choriocarcinoma cell lines and VEGF is highly expressed in these cells [ 47 ]. Indeed, choriocarcinoma can even be developed in males, and therefore not related to the increased in preeclampsia as molar gestations do.…”
Section: Discussionmentioning
confidence: 99%
“…In contrast, choriocarcinoma a very aggressive neoplasm originated from trophoblastic cells of the placenta is characterized by highly pro-angiogenic with rapidly growing rate and metastatic malignant epithelial tumors [ 19 ]. The angiogenic proteins, as VEGF and PlGF are overexpressed in these tumors [ 20 , 21 ], whereas sFlt1 expression is strongly suppressed [ 22 ]. Incidence of choriocarcinoma has been reported 1 in 24,096 pregnant patients [ 23 ].…”
Section: Introductionmentioning
confidence: 99%