Production of angiotensin converting enzyme by rheumatoid synovial membrane.

Veale, Douglas J.; Yanni, G.; Bresnihan, Barry; FitzGerald, Oliver

doi:10.1136/ard.51.4.476

Cited by 40 publications

(25 citation statements)

References 26 publications

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“…The current findings appear to contradict some previous reports of association between the I/I genotype and improved endurance or function. Yet the findings of other studies in older adults including those of response to exercise in wellfunctioning older adults (Kritchevsky et al 2005), of greater gains in knee extensor strength (Giaccaglia et al 2008), and of improved hand-grip strength (Yoshihara et al 2009) all associated with the ACE D/D genotype also contradict other areas of the literature in which ACE has been implicated with forms of arthritis (Veale et al 1992;Dalbeth and Haskard, 2005).…”

Section: Discussioncontrasting

confidence: 48%

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

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Matera

et al. 2010

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The association between angiotensinconverting enzyme (ACE) genotypes and functional decline in older adults remains controversial. To assess if ACE gene variations influences functional abilities at older age, the present study explored the association between the common ACE insertion/ deletion (I/D) polymorphism and disability measured with activities of daily living (ADL) in hospitalized older patients. We analyzed the frequency of the ACE genotypes (I/I, I/D, and D/D) in a population of 2,128 hospitalized older patients divided according to presence or absence of ADL disability. Logistic regression analysis adjusted for possible confounding factors, identified an association between the I/I genotype with ADL disability (OR=1.54, 95% CI 1.04-2.29). This association was significant in men (OR=2.01, 95% CI 1.07-3.78), but not in women (OR=1.36, 95% CI 0.82-2.25). These results suggested a possible role of the ACE polymorphism as a genetic marker for ADL disability in hospitalized older patients.

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Section: Discussioncontrasting

confidence: 48%

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

Seripa

Paroni

Matera

et al. 2010

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“…This complements the in vitro observation that angiotensin-induced proliferation and matrix component biosynthesis in fetal human mesangial cells is blocked by co-administration of an angiotensin type-1 receptor antagonist [30]. ACE is produced by endothelium and mononuclear cells of macrophage origin, and ACE activity is significantly increased in patients with inflammatory arthritis compared to subjects with noninflammatory arthritis [31]. It has been postulated that locally generated angiotensin acts on synovial angiotensin receptors to modulate synovial perfusion and growth [32].…”

Section: Discussionmentioning

confidence: 67%

Association of angiotensin-converting enzyme (ACE) gene insertion–deletion polymorphism with spondylarthropathies

et al. 2007

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Low back pain (LBP) is a common medical problem. Interaction between genetic and environmental factors predisposes individuals to LBP even at an early age. Inflammatory back pain or spondylarthropathies include ankylosing spondylitis (AS), psoriatic arthritis (PSA), reactive arthritis enteropathic and undifferentiated arthropathies. Angiotensin-converting enzyme (ACE) plays an important role in circulatory homeostasis, physiology of vasculature and inflammation. The insertion-deletion (I/D) polymorphism of the ACE gene has been shown to determine the plasma and tissue levels of ACE especially in the synovial fluid. The aim of this study was to investigate an association between ACE gene I/D polymorphism and inflammatory back pain (spondylarthropathies) secondary to ankylosing spondylitis (AS), psoriatic arthritis, inflammatory bowel disease and undifferentiated spondylarthropathies. The prevalence of ACE gene I/D polymorphism genotypes was determined in 63 patients with inflammatory back pain by polymerase chain reaction (PCR) and compared with that in 111 healthy controls. Of the 63 patients studied, 45 (71.4%) were with AS, 13 (20.6%) were with PSA, 4 (6.3%) were with reactive arthropathy and 1 (1.6%) manifested undifferentiated arthropathy. There were 43 males and 20 females. Mean age of patients was 39.0+/-11.36 years, age at onset of spondylarthropathy was 27.7+/-7.49 years and disease duration was 10.3+/-7.74 months. The controls were selected to match with the patients group in terms of gender ratio, age and ethnicity. The ACE gene polymorphism showed an overall significant difference between patients and controls (p=0.050). When the ID and II genotype frequency was combined and compared with that for DD genotype amongst patient and control groups, a considerably higher incidence was detected for ID and II genotypes than the DD genotype in spondylarthropathy patients compared to that in the controls (p=0.036). This study showed a significant association of the I-allele of ACE gene I/D polymorphism with spondylarthropathy in Kuwaiti Arabs.

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“…Angiotensin converting enzyme is expressed in the synovial membranes from patients with the adult form of rheumatoid arthritis (RA), and a role for this enzyme in the pathophysiology has been suggested [27][28][29]. However, a recent study did not Wnd a signiWcant diVerence between the prevalence of ACE gene polymorphism in adults with rheumatoid arthritis (RA) and controls, and between severe and non-severe RA [30].…”

Section: Discussionmentioning

confidence: 99%

Angiotensin-converting enzyme gene polymorphism in patients with psoriatic arthritis

et al. 2007

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To investigate the frequency of angiotensinconverting enzyme (ACE) gene insertion/deletion (I/D) polymorphism genotypes in adults with psoriatic arthritis (PsA), a heterogeneous chronic disease with autoimmune pathology. ACE gene I/D polymorphism inXuences the plasma and tissue levels of ACE and has an involvement in inXammatory mechanism. The frequency of ACE gene I/D polymorphism genotypes was determined in 51 adults with PsA from Kuwait, and compared to that in 100 ethnically matched healthy controls using polymerase chain reaction. The distribution of ACE I/D polymorphism and allele frequencies in PsA patients were not signiWcantly diVerent from controls (P > 0.05). Further analyses of PsA patients showed that ACE I/D gene polymorphism was not associated with family history, clinical manifestations, and disease severity. However, the frequency of II genotype was signiWcantly higher in patients with late disease onset than in those with early onset (25 vs. 3%; P = 0.04). No diVerence was found between the distribution of the ACE genotype in PsA patients and the general population in Kuwait.However, the presence of II genotype may confer susceptibility to the development of late onset PsA.

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Production of angiotensin converting enzyme by rheumatoid synovial membrane.

Cited by 40 publications

References 26 publications

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

Angiotensin-converting enzyme (ACE) genotypes and disability in hospitalized older patients

Association of angiotensin-converting enzyme (ACE) gene insertion–deletion polymorphism with spondylarthropathies

Angiotensin-converting enzyme gene polymorphism in patients with psoriatic arthritis

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