Production of angkak through co-culture of Monascus purpureus and Monascus ruber

Panda, Bibhu Prasad; Javed, Saleem; Ali, Mohd

doi:10.1590/s1517-83822010000300028

Cited by 19 publications

(18 citation statements)

References 20 publications

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“…These cultures were used as inoculum for both the Monascus sp. For co-culture, these seed cultures were mixed in the ratio of 1:1 (Panda et al 2010a). …”

Section: Inoculum Preparationmentioning

confidence: 99%

“…It was then filtered with Whattman filter paper and filtrate was centrifuged at 3,000×g for 8 min. (Panda et al 2010a). …”

Section: Extraction Of Lovastatinmentioning

confidence: 99%

“…The mobile phase was Acetonitrile/water (65:35 v/v and 3.5 pH), acidified with ortho-phosphoric acid. The flow rate was set to 1.0 ml/ min with pressure settings as 2,500 psi and the detection was carried out using the wavelength of 235 nm by UV detector (SPD10A VP) (Panda et al 2010a). …”

Section: Hplc Condition For Lovastatinmentioning

confidence: 99%

“…Maximum reports present in literature talk about the production of lovastatin using monocultures of these Monascus sp. or co-culture of these strains (Panda et al 2010a). There is a need to explore other…”

Section: Introductionmentioning

confidence: 99%

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Bio-synthesis and screening of nutrients for lovastatin by Monascus sp. under solid-state fermentation

Dikshit

Tallapragada

2015

J Food Sci Technol

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In this study Monascus strains were screened for lovastatin production. These strains namely Monascus purpureus, Monascus sanguineus and their co-culture were able to produce lovastatin in solid state fermentation. Sensitivity of lovastatin was tested on Saccharomycess cerevaceae and Candida sp. where the former exhibited large zone of inhibition as compared to the latter. Presence of lovastatin was confirmed by thin layer chromatography (TLC) and high performance liquid chromatography (HPLC). Quantification of lovastatin was done with UV spectrometer at 238 nm. Further, Plackett-Burman methodology was applied for screening of nutrients for lovastatin production. Different substrates were screened and amongst them, wheat bran was found to be the best substrate for lovastatin synthesis. Seven nutrients were screened according to the Plackett-Burman design for lovastatin yield. MgSO 4 .7H 2 O showed the positive impact on lovastatin yield whereas lactose showed the maximum negative effect with M. purpureus. For M. sanguineus, CaCl 2 .2H 2 O displayed the dominant negative effect and soybean the significant positive. With co-culture, the effect of lactose was positive whereas that of malt extract was negative and dominant. The maximum lovastatin yield for M. sanguineus, M. purpureus and co-culture was estimated to be 0.402, 0.27 and 0.26 mg/g respectively.

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“…These cultures were used as inoculum for both the Monascus sp. For co-culture, these seed cultures were mixed in the ratio of 1:1 (Panda et al 2010a). …”

Section: Inoculum Preparationmentioning

confidence: 99%

“…It was then filtered with Whattman filter paper and filtrate was centrifuged at 3,000×g for 8 min. (Panda et al 2010a). …”

Section: Extraction Of Lovastatinmentioning

confidence: 99%

Section: Hplc Condition For Lovastatinmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Bio-synthesis and screening of nutrients for lovastatin by Monascus sp. under solid-state fermentation

Dikshit

Tallapragada

2015

J Food Sci Technol

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“…The angkak has long been recognized as a folk medicine for improving food digestion and blood circulation and for treatment of muscle bruising and dysentery. The manufacturing process for angkak and its therapeutic applications are well documented in the ancient Chinese pharmacopoeia (Ben-Taso-Gum-Mu) (Miyake Panda et al, 2010). Metals are an integral part of all ecosystems (Raza et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

Gibberellic acid, amino acids (glycine and L-leucine), vitamin B2 and zinc as factors affecting the production pigments by Monascus purpureus in a liquid culture using response surface methodology

Baneshi¹,

Azizi²,

Saberi³

et al. 2014

Afr. J. Biotechnol.

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The combined effects of zinc, gibberellic acid, vitamin B 2 , amino acids (glycine and L-leucine) on pigment production were evaluated in a liquid culture of Monascus purpureus. In this study, response surface design was used to optimize each parameter. The data were analyzed using Minitab 14 software. Five parameters were applied by using response surface methodology for pigment production in liquid cultures. Four zinc, 11 gibberellic acids, three vitamins B 2 , eleven and fifteen amino acids (glycine and L-leucine) respectively; levels were evaluated. The highest production of pigment was reached with a 10 mg/l vitamin B 2 , 50 mg/l gibberellic acid and 50 mg/l glycine amino acid.

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Enrichment of dimerumic acid in Monascus‐fermented rice and its in vivo antioxidant activity

2021

Self Cite

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Monascus-fermented rice (MFR) has been used in traditional Chinese and Japanese medicine for the revitalization of blood, digestion problems, and cardiovascular disorders. Through a biotechnological approach, MFR is produced by the solid-state fermentation of rice by Monascus spp. MFR has remarkable therapeutic properties as it contains several bioactive compounds, and dimerumic acid is one of the important siderophore-based antioxidant fermentative metabolites found in it. This study aimed to screen out the medium composition for the production of dimerumic acid (DMA) and evaluate its antioxidant potential. Different strains of Monascus purpureus Microbial Type Culture Collection & Gene Bank (MTCC) 410, 369, 1090 and Monascus ruber MTCC 1880, 2326 and Monascus pilosus CBS 286.34, CBS 290.34 with different solid substrate were screened for maximum yield of DMA. Solid-state fermentation of longgrain rice (Oryza sativa) by Monascus pilosus CBS 290.34 was the best for DMA production. The optimized medium parameters in rice for the highest yield of DMA were glucose (75.13 mg/g), soya extract (19.33 mg/g), malt extract (35.14 mg/g), and calcium carbonate (0.29 mg/g). The predicted values for medium parameters were in good agreement with the experimental data. MFR enriched with DMA showed potent antioxidant and lipid lowering capacity in both in vitro and in vivo. It can be explored further for the development of nutraceuticals as a natural antioxidant.

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Production of angkak through co-culture of Monascus purpureus and Monascus ruber

Cited by 19 publications

References 20 publications

Bio-synthesis and screening of nutrients for lovastatin by Monascus sp. under solid-state fermentation

Bio-synthesis and screening of nutrients for lovastatin by Monascus sp. under solid-state fermentation

Gibberellic acid, amino acids (glycine and L-leucine), vitamin B2 and zinc as factors affecting the production pigments by Monascus purpureus in a liquid culture using response surface methodology

Enrichment of dimerumic acid in Monascus‐fermented rice and its in vivo antioxidant activity

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