Production of Antibacterial and Antifungal Metabolites by Streptomyces Violaceusniger and Media Optimization Studies for the Maximum Metabolite Production

Tripathi, C. K. M.; Praveen, Vandana; Singh, Vineeta; Bihari, Vinod

doi:10.1007/s00044-004-0118-3

Cited by 23 publications

(21 citation statements)

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“…It is important to clarify the taxonomy of S. hygroscopicus, S. violaceusniger and related strains, not least because members of the S. violaceusniger 16S rRNA gene clade are a source of antibacterial and antifungal metabolites (DeBoer et al 1970;Lam et al 1990;Tripathi et al 2004), biological control agents (TrejoEstrada et al 1998a, b;Chamberlain and Crawford 1999), enantioselective biocatalysts (Molinari et al 2005) and immunosuppressants, including rapamycin (Vezina et al 1975). Authenticated members of the S. violaceusniger 16S rRNA gene clade show the same pattern of HPLC-detected secondary metabolites, namely eliaophylin, geldanamycin, nigericin and a polyene (Ward and Goodfellow 2004), a result consistent with those of earlier studies (Allen and Ritchie 1994; Fang et al 2000).…”

Section: Introductionmentioning

confidence: 99%

The Streptomyces violaceusniger clade: a home for streptomycetes with rugose ornamented spores

Goodfellow

Kumar

Labeda

et al. 2007

Antonie van Leeuwenhoek

123

105

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The taxonomic status of 16 strains received as Streptomyces hygroscopicus, Streptomyces melanosporofaciens, Streptomyces sparsogenes, Streptomyces sporoclivatus and Streptomyces violaceusniger was evaluated in a polyphasic study. Eleven of the organisms formed a distinct clade in the Streptomyces 16S rRNA gene tree with the type strains of Streptomyces asiaticus, Streptomyces cangkringensis, Streptomyces indonesiensis, Streptomyces javensis, Streptomyces malaysiensis, Streptomyces rhizosphaericus, Streptomyces yatensis and Streptomyces yogyakartensis, the members of this group produced rugose ornamented spores in spiral spore chains. The eleven strains were assigned to three established and four novel species, namely Streptomyces albiflaviniger sp. nov., Streptomyces demainii sp. nov., Streptomyces geldanamycininus sp. nov., Streptomyces griseiniger sp. nov., and Streptomyces hygroscopicus, Streptomyces melanosporofaciens and Streptomyces violaceusniger. It is also proposed that S. sporoclivatus becomes a subjective synonym of S. melanosporofaciens. S. sparsogenes NRRL 2940(T), which produced ridged ornamented spores in spiral spore chains, formed a distinct phyletic line in the Streptomyces 16S rRNA gene tree and was readily distinguished from the other strains using a range of phenotypic properties. S. violaceusniger strains NRRL 8097, NRRL B-5799, NRRL 2834 and ISP 5182 fell outside the S. violaceusniger 16S rRNA gene clade and formed either smooth or ridged ornamented spores in either flexuous or spiral spore chains. These organisms were distinguished from one another and from their closest phylogenetic neighbors and were considered to merit species status as Streptomyces auratus sp. nov., Streptomyces phaeoluteichromatogenes sp. nov., Streptomyces phaeogriseichromatogenes sp. nov., and Streptomyces phaeoluteigriseus sp. nov., respectively.

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Section: Introductionmentioning

confidence: 99%

The Streptomyces violaceusniger clade: a home for streptomycetes with rugose ornamented spores

Goodfellow

Kumar

Labeda

et al. 2007

Antonie van Leeuwenhoek

123

105

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“…Natural products have long been used as templates for the design of new lead compounds which may be useful against infectious diseases, such as blactams, tetracyclins, echinocandins, and macrolydes (Newman and Cragg, 2007). In this context, several metabolites of different structural patterns have proven active against microorganisms, and screening of extracts is a valid strategy being exploited to discover novel antimicrobial agents (Acharya et al, 2008;Singh et al, 2008;Tripathi et al, 2004;Viswanathan et al, 2004;Wang et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Piperamides and their derivatives as potential anti-trypanosomal agents

et al. 2009

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We describe herein an evaluation of the trypanocidal effect of eight piperamides (1-8) isolated from Piper tuberculatum bearing dihydropyridone, piperidine, and isobutyl moieties against epimastigote forms of Trypanosoma cruzi, the causative agent of Chagas' disease. Based on such results, three hydrogenated and two hydrolyzed derivatives (10-14) were prepared and evaluated as well. The dihydropyridone amides (1-3) displayed higher anti-trypanosomal activity. The (Z)-piplartine (1) showed higher activity with a 50% inhibition concentration (IC 50 ) value of 10.5 lM, almost four times more potent than the positive control, benznidazole (IC 50 = 42.7 lM), and should be further evaluated as a suitable hit for the design of new antiprotozoal agents.

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“…It is evident from the present study that representatives of over 40 new streptomycete species were detected in the small clone library (45 clones) generated from the six different environmental samples. It is reasonable to conclude that the new phyletic lines share a common history with organisms known to be a rich source of new bioactive compounds (Vezina et al , 1975; Kino et al , 1987; Tripathi et al , 2004; Ward & Goodfellow, 2004). This diversity already exceeds that of the current cultivable components of the S. violaceusniger 16S rRNA gene clade, thereby highlighting the biotechnological potential and ecological significance of members of this taxon.…”

Section: Discussionmentioning

confidence: 99%

Diversity and geographical distribution of members of the Streptomyces violaceusniger 16S rRNA gene clade detected by clade-specific PCR primers

Kumar

Aiemsum-ang

Ward

et al. 2007

FEMS Microbiology Ecology

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The Streptomyces violaceusniger 16S rRNA gene clade contains organisms that are of ecological interest and a rich source of novel bioactive metabolites. Improvements in the classification of members of the S. violaceusniger clade made it possible to design, evaluate and use an oligonucleotide primer set to gain an insight into the presence, distribution and taxonomic diversity of members of this taxon in environmental samples. In silico testing showed that the primers had a perfect match with representatives of the S. violaceusniger clade. The primers, designated S-S-Svio-66-a-S-20 and S-S-Svio-1274-a-A-20, amplified an approximately 1190-bp stretch of 16S rRNA gene from authenticated members of the S. violaceusniger clade, but not from representatives of other actinomycete taxa. Following amplification of DNA extracted from sediment and soil samples, the sequences of cloned PCR products confirmed the specific amplification of target sequences in 87% of the clones; the use of 16S rRNA gene fragment similarity correlations indicated that the clones represented new species. The primers can be used to facilitate the isolation of novel members of the S. violaceusniger 16S rRNA gene clade by allowing prescreening of environmental samples and the subsequent detection and retrieval of targetted strains through the use of selective isolation procedures.

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Production of Antibacterial and Antifungal Metabolites by Streptomyces Violaceusniger and Media Optimization Studies for the Maximum Metabolite Production

Cited by 23 publications

References 0 publications

The Streptomyces violaceusniger clade: a home for streptomycetes with rugose ornamented spores

The Streptomyces violaceusniger clade: a home for streptomycetes with rugose ornamented spores

Piperamides and their derivatives as potential anti-trypanosomal agents

Diversity and geographical distribution of members of the Streptomyces violaceusniger 16S rRNA gene clade detected by clade-specific PCR primers

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