Production of Antibody in Patients with Uremia

Stoloff, Irwin L.; Stout, Robert W.; Myerson, Ralph M.; Havens, W. Paul

doi:10.1056/nejm195808142590703

Cited by 52 publications

(9 citation statements)

References 12 publications

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“…Low or moderate azotemia (urea 70 mg%) does not hamper diphtheria antitoxin production [42], With advanced renal insufficiency, however, very low agglutination titers are found after typhoid immunization. Acute skin reactions against several natural antigens (pollen, Candida) are also sup pressed [25], Skin reactions after passive immunization and after subcutane ous histamine injection, on the other hand, remain unchanged [44], These skin reactions are not useful for individual testing, because signifi cant differences are only found when comparing large groups.…”

Section: Acute Immunization Proceduresmentioning

confidence: 99%

Immune System in Uremia

Dobbelstein¹

1976

Nephron

127

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Section: Acute Immunization Proceduresmentioning

confidence: 99%

Immune System in Uremia

Dobbelstein¹

1976

Nephron

127

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“…[12][13][14][15] Patients with posttraumatic renal insuffi ciency received tetanus toxoid and had nor mal levels of antitoxin [24]. A group of Schick-negative azotemic patients were im munized with diphteria toxoid and a regular pattern of response was observed [25], In one study, twenty-one patients with chronic renal insufficiency of varying severity not on dialysis were immunized with bivalent in fluenza vaccine [26], The antibody response to influenza vaccine was precluded by the severity of the renal impairment, i.e. the more severe the renal impairment the worse the response [26], Osanloo et al [27] chal lenged three groups (normal, azotemic, HD) of patients with inactivated bivalent in fluenza vaccine.…”

Section: Humoral Immunitymentioning

confidence: 99%

Immune Abnormalities in Renal Failure and Hemodialysis

Kay¹,

Raij²

1986

Blood Purif

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Considerable work needs to be done in order to understand the immunosupressive effect of ‘uremia’ and the lymphocyte changes induced by hemodialysis. For example, the lymphocyte population dynamics can be further defined using monoclonal antibodies specific for lymphocyte subgroups. In vitro assays are available for lymphokine detection (i.e. IL-1, IL-2 which are important for T cell function) and may be correlated with both the clinical state and overall immunobiological status of hemodialyzed patients. The possibility of specifically delineating the extent of the immune system dysfunction in renal failure patients (on or off dialysis) is at hand. With this knowledge it will be possible to manipulate their management so as to minimize function alterations.

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“…Uraemic patients, although apparently capable of exhibiting a normal humoral response [11,42], have an impairment of the rejection of renal or skin allografts, a defect in immunity which appears to be closely relat-ed to delayed-type hypersensitivity. Infectious complications, often fatal, are a common outcome of the disease [31].…”

Section: Introductionmentioning

confidence: 99%

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

McIntosh

Hansen

Ziegler

et al. 1976

Int Arch Allergy Immunol

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The humoral, cellular and neutrophil responses of uraemic patients maintained by haemodialysis were compared with those of renal transplant recipients. Humoral immunity was reduced only in the transplant group. Cell-mediated immunity was abnormal in both groups but more decreased in the transplant group studied particularly within 3 months of transplantation. The neutrophil bactericidal capacities were defective in both groups. Infectious complications were often associated with defective cellular immunity, but fatal infections occurred only in transplant patients over 40 years of age with combined cellular and neutrophil defects. No single test was predictive of graft survival in uraemic patients. The depressed cellular immune responses in uraemia, of the degree seen in the immunosuppressed transplant recipient, may explain the better prognosis of renal transplants compared with other organ transplants.

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Production of Antibody in Patients with Uremia

Cited by 52 publications

References 12 publications

Immune System in Uremia

Immune System in Uremia

Immune Abnormalities in Renal Failure and Hemodialysis

Defective Immune and Phagocytic Functions in Uraemia and Renal Transplantation

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