Production of Antifungal and Antibacterial Substances by Fungi; Preliminary Examination of 166 Strains of Fungi Imperfecti

Brian, P. W.; Hemming, H. G.

doi:10.1099/00221287-1-2-158

Cited by 42 publications

(10 citation statements)

References 26 publications

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“…produced bacteriostatic substances against Bacterium coli, S. aureus, and Pseudomonas pyocyanea. Brian and Hemming (1947) reported that the culture filtrates of different species of Aspergillus displayed antibacterial activity against S. aureus and Salmonella typhi. Irobi et al (2000) worked on A. quadrilineatus isolated from moldy Acha, a common cereal grown among the plateau state of Nigeria.…”

Section: Antibacterial Properties Of Crude Extractsmentioning

confidence: 99%

Overview on antibacterial metabolites from terrestrialAspergillusspp

Al-Fakih

Almaqtri

2019

Mycology

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Medicines developed from natural sources are a frequent target for the research and discovery of antimicrobial compounds. Discovering of penicillin in 1928 was a motive to explore of nature as a source of new antimicrobial agents. Fungi produce a diverse range of bioactive metabolites, making them rich source of different types of medicines. The purpose of this paper was to review studies on antibacterials from terrestrial Aspergillus published exclusively during 1942-2018, with emphasis on their antibacterial activities, structures, and mechanisms of action if present. According to the results from different studies in the world, large number of compounds and extracts showed different activities against different bacterial species, including Gram-positive and Gram-negative bacteria. The most prominent result was that of the compound CJ-17,665, isolated from A. ochraceus, showing good activity against multi-drug resistant Staphylococcus aureus, which is well-recognised to be one of the most important current public health problem. These findings may motivate scientists to undertake a project that may result in the development of novel antibacterial drugs from terrestrial-derived Aspergillus spp., although further toxicity assays (in vivo) must be performed before their application.

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Section: Antibacterial Properties Of Crude Extractsmentioning

confidence: 99%

Overview on antibacterial metabolites from terrestrialAspergillusspp

Al-Fakih

Almaqtri

2019

Mycology

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“…The presence of an antifungal compound in culture filtrates of Trichothecizlm roseurn was reported by Brian & Hemming (1947), and the substance, trichothecin, responsible for the antifungal activity was isolated and some of its chemical and biological properties described by Freeman & Morrison (1949 a, b), In addition to its antifungal action, trichothecin was reported by Hessayon (1951) to give well-marked stimulation of mycelial growth, at exceedingly small concentrations. Other metabolic products of the mould have been described by Robertson, Smithies & Tittensor (1949) and by Freeman, Morrison & Michael (1949).…”

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confidence: 99%

Further Biological Properties of Trichothecin, an Antifungal Substance from Trichothecium roseum Link, and its Derivatives

Freeman¹

1955

Journal of General Microbiology

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SUMMARY: Production of trichothecin in submerged aerated cultures of a strain of Trichothecium roseum is described. The antibiotic is active in vitro against certain fungi pathogenic in man, including the causative organisms of some generalized infections and several of the common skin pathogens. I n general, the sensitive pathogens were inhibited a t trichothecin concentrations of 16 p.p.m. or less and the antifungal activity was not influenced by the presence of blood serum (5 yo) in the medium. Trichothecin is toxic to laboratory animals; single doses at the rate of 250 mg./kg. intravenously in mice and subcutaneously in rats resulted in death. The antibiotic also produced a reaction when brought into contact with the skin.The antifungal activity of a series of esters related to trichothecin was of the same order as that of the parent substance. With the exception of esters in which the ethylenic double bond of trichothecolone had been saturated, none of the known derivatives or fission products exhibits more than a very slight activity. The presence of a large excess of p-indolylacetic acid did not affect the antifungal activity of trichothecin. This suggests that the effect of the latter in inhibiting plant growth regulating activity of /3-indolylacetic acid and related substances is not due to molecular combination of the two substances.

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“…The basis for choosing the RP chromatography is the nature and type of the selected compound. Mycophenolate mofetil is a low molecular weight, ester pro-drug of mycophenolic acid (MPA) [8] and hence is a neutral molecule. Reversed phase chromatography is the first [33,34].…”

Section: Resultsmentioning

confidence: 99%

LC-MS Compatible Stability Indicating RP-UPLC Method for the Estimation of Ester Prodrug of Mycophenolic Acid in Injection Formulation

Rao¹,

Krishna²,

Bellam³

et al. 2018

Asian J. Chem.

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This study explores the ultra performance liquid chromatography for the quantification of mycophenolate mofetil (an immunosuppressant agent) in an injection formulation. Mycophenolate mofetil was separated from its seven specified impurities on HSS (high strength silica) C18 column (100 × 2.1 mm, 1.8 µm). The optimized mobile phase is compatible to mass spectrometry and hence the method can be equally run on LC-MS system for mass determinations. Efficient UV detection at 250 nm enabled determination of mycophenolate mofetil with no interference from placebo solution, diluent and other specified and unspecified impurities. The retention time of mycophenolate mofetil in the method was 1.79 min and all other impurities were eluted within in 8 min. The method optimization studies show that the selectivity of mycophenolate mofetil and its impurities was dependent on the type of organic solvent and its elution strength. The method was validated for specificity, linearity, precision, accuracy and robustness in range of 50 to 150 % of target analyte concentration (i.e. 62.50-195.31 µg mL -1 ). The linearity of peak area responses versus concentrations was demonstrated by linear least square regression analysis. An excellent linear relation exists between the concentration and detector response (R 2 > 0.9999). Precision of the test method was proved with a relative standard deviation less than 1.0 %.

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Production of Antifungal and Antibacterial Substances by Fungi; Preliminary Examination of 166 Strains of Fungi Imperfecti

Cited by 42 publications

References 26 publications

Overview on antibacterial metabolites from terrestrialAspergillusspp

Overview on antibacterial metabolites from terrestrialAspergillusspp

Further Biological Properties of Trichothecin, an Antifungal Substance from Trichothecium roseum Link, and its Derivatives

LC-MS Compatible Stability Indicating RP-UPLC Method for the Estimation of Ester Prodrug of Mycophenolic Acid in Injection Formulation

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