Production of bioactive metabolites by submerged fermentation of the medicinal mushroom <i>Antrodia cinnamomea</i>: recent advances and future development

Zhang, Bobo; Guan, Yu-Yan; Hu, Peng-Fei; Chen, Lei; Xu, Guowang; Liu, Li; Cheung, Peter C.K.

doi:10.1080/07388551.2019.1577798

Cited by 50 publications

(37 citation statements)

References 79 publications

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“…Indigenous or traditional medicines involving herbal extracts are often considered to be ‘natural’ and causing fewer side effects than synthetic pharmacotherapies. The unique fungus A. cinnamomea has been used for hundreds of years in traditional medicines of Taiwan to treat liver diseases, food and drug intoxication, hypertension, cancers and inflammatory disorders, amongst other conditions ( 15 , 53 ). Evidence has shown that extracts from A. cinnamomea have anti-inflammatory properties, such as the active compound ergostatrien-3β-ol (ST1), which significantly decreases mRNA levels of pro-inflammatory genes including IL-6 and inducible nitric oxide synthase ( iNOS ) and levels of TNF-α, NF-κB and IL-6 protein expression, reducing inflammatory reactions after skin flap surgery ( 54 ).…”

Section: Discussionmentioning

confidence: 99%

“…In conclusion, our observations indicate that the inhibition of TNF-α, IL-1β and IL-8 production in RASFs and in serum and synovial tissue from CIA mice attenuates signs and symptoms of RA ( Figure 9 ) and that Antcin K significantly inhibits these proinflammatory cytokines via the FAK/PI3K, AKT and NF-κB signaling cascades. Derivatives of A. cinnamomea have exhibited varying pharmacological activity in experimental models of tumors, inflammation, immunomodulation, hepatotoxicity, diabetes and hyperlipidemia ( 53 ). In one study, triterpenoids isolated from A. cinnamomea mycelia were protective against acute alcohol-induced liver injury in mice ( 64 ) and in another study, A. cinnamomea polysaccharides inhibited vascular endothelial growth factor receptor (VEGFR) signaling in bovine aortic endothelial cells ( 65 ).…”

Section: Discussionmentioning

confidence: 99%

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Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis

et al. 2021

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Extracts from Taiwan’s traditional medicinal mushroom, Antrodia cinnamomea, exhibit anti-inflammatory activities in cellular and preclinical studies. However, this paper is the first to report that Antcin K, a triterpenoid isolated from A. cinnamomea, inhibits proinflammatory cytokine production in human rheumatoid synovial fibroblasts (RASFs), which are major players in rheumatoid arthritis (RA) disease. In our analysis of the mechanism of action, Antcin K inhibited the expression of three cytokines (tumor necrosis factor alpha [TNF-α], interleukin 1 beta [IL-1β] and IL-8) in human RASFs; cytokines that are crucial to RA synovial inflammation. Notably, incubation of RASFs with Antcin K reduced the phosphorylation of the focal adhesion kinase (FAK), phosphoinositide 3-kinase (PI3K), protein kinase B (AKT) and nuclear factor-κB (NF-κB) signaling cascades, all of which promote cytokine production in RA. Intraperitoneal injections of Antcin K (10 mg/kg or 30 mg/kg) attenuated paw swelling, cartilage degradation and bone erosion, and decreased serum levels of TNF-α, IL-1β, IL-8 in collagen-induced arthritis (CIA) mice; in further experiments, IL-6 levels were similarly reduced. The inhibitory effects of Antcin K upon TNF-α, IL-1β and IL-8 expression in human RASFs was achieved through the downregulation of the FAK, PI3K, AKT and NF-κB signaling cascades. Our data support clinical investigations using Antcin K in RA disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis

et al. 2021

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“…Several groups have reported the efficacy of terpenoids for therapeutic treatments of neurodegenerative 39 , antiviral 40 , and more. Several studies have looked at more closely the health benefits of terpenoid extracted from various mushrooms such as Ganodherma ludicum 41 , Antrodia cinnamomea 42 , Inonotus obliquus 43 , and others, but to the author's knowledge, there has not been a study of therapeutics effects of terpenoid extracts from Agaricus bisporus. The presence of terpenoid could also be one of the high tyrosinase inhibition activity in the Agaricus bisporus in our work.…”

Section: Qualitative Phytochemical Screeningmentioning

confidence: 99%

Assessment of Agaricus bisporus Mushroom as Protective Agent Against Ultraviolet Exposure

Hwang

Halim

Sugata

et al. 2021

Preprint

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Mushrooms are versatile materials with applications including but not limited to food, cosmetics, and pharmaceutical industries. In this work, the potential of the common button mushroom, Agaricus bisporus, as a protective against ultraviolet exposure was assessed. The assessment was done by investigating the radical scavenging activity, sun protecting capability, and tyrosinase inhibiting properties of Agaricus bisporus ethanolic extract. The extraction was carried out using absolute ethanol as its solvent at low to room temperatures. The bioactive components of the ethanolic extract were analysed for its phenolic and flavonoid contents quantitatively, while other phytochemical agents were analysed qualitatively. The Agaricus bisporus ethanolic extract was found to exhibit low radical scavenging ability with %RSA IC50 of ~5456 μg/mL, low to moderate sun protecting factor of ~ 5.355 at 5000 ppm concentration, and high tyrosinase inhibition property with IC50 of ~2 μg/mL. The high tyrosinase inhibition property was found to correlate with relatively high total phenolic content of ~1143 mg GAE/100g for Agaricus bisporus and the presence of terpenoid in the ethanolic extract.

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“…The mycelium of macrofungi can also be cultivated under submerged fermentation in shaking flasks. Both the fruiting body and liquid-cultivated mycelium have been reported to produce a number of useful constituents, including bioactive lead compounds (such as alkaloids, polyketides, terpenoids, and steroids) and degradation-related oxidative enzymes (such as laccase, lignin peroxidase, and manganese peroxidase) (Qu et al, 2019;Shen et al, 2019;Zhang et al, 2019;Lira-Pérez et al, 2020), which make macrofungi an important resource for agriculture, industry, and medicine.…”

Section: Introductionmentioning

confidence: 99%

Coculture, An Efficient Biotechnology for Mining the Biosynthesis Potential of Macrofungi via Interspecies Interactions

Sun

Han

et al. 2021

Front. Microbiol.

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Macrofungi, which are also known as mushrooms, can produce various bioactive constituents and have become promising resources as lead drugs and foods rich in nutritional value. However, the production of these bioactive constituents under standard laboratory conditions is inefficiency due to the silent expression of their relevant genes. Coculture, as an important activation strategy that simulates the natural living conditions of macrofungi, can activate silent genes or clusters through interspecific interactions. Coculturing not only can trigger the biosynthesis of diverse secondary metabolites and enzymes of macrofungi, but is also useful for uncovering the mechanisms of fungal interspecific interactions and novel gene functions. In this paper, coculturing among macrofungi or between macrofungi and other microorganisms, the triggering and upregulation of secondary metabolites and enzymes, the potential medicinal applications, and the fungal–fungal interaction mechanisms are reviewed. Finally, future challenges and perspectives in further advancing coculture systems are discussed.

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Production of bioactive metabolites by submerged fermentation of the medicinal mushroom Antrodia cinnamomea: recent advances and future development

Cited by 50 publications

References 79 publications

Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis

Antcin K Inhibits TNF-α, IL-1β and IL-8 Expression in Synovial Fibroblasts and Ameliorates Cartilage Degradation: Implications for the Treatment of Rheumatoid Arthritis

Assessment of Agaricus bisporus Mushroom as Protective Agent Against Ultraviolet Exposure

Coculture, An Efficient Biotechnology for Mining the Biosynthesis Potential of Macrofungi via Interspecies Interactions

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