Production of blood coagulation factory V and tissue thromboplastin by macrophages in vitro

Østerud, Bjarne; Bøgwald, Jarl; Lindahl, Ulf; Seijelid, R.

doi:10.1016/0014-5793(81)80363-8

Cited by 70 publications

(22 citation statements)

References 11 publications

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“…In contrast to other studies (14,15,28,29), however, no dosedependent enhancement of monocyte tissue factor production was found when elutriator-purified lymphocytes were added to the monocyte cultures. As our monocyte preparations contained small numbers of lymphocytes (1-8%), no comment can be made upon the claim that lymphocytes are absolutely required for stimulation of monocyte tissue factor production (15,30). The addition of platelets to the monocyte cultures did enhance the amount of tissue factor activity produced (31).…”

Section: Methodsmentioning

confidence: 87%

Binding of human factor VII and VIIa to monocytes.

Broze¹

1982

J. Clin. Invest.

180

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Section: Methodsmentioning

confidence: 87%

Binding of human factor VII and VIIa to monocytes.

Broze¹

1982

J. Clin. Invest.

180

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“…The thromboplastin activity o f monocytes was determined as reported earlier [16,18]. This assay is based on the ability o f thromboplastin to accelerate factor VII activation o f factor X.…”

Section: Quantitation O F Thromboplastin Activitymentioning

confidence: 99%

Effect of Steroids during <i>Escherichia col</i><i>i</i> Endotoxinaemia in Rabbits

Østerud

Tindall²,

Olsen³

1989

Pathophysiol Haemos Thromb

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A study was carried out on the effect of high doses of methylprednisolone to rabbits in combination with or after challenging them with Escherichia coli endotoxin. The animals given steroids simultaneously with the endotoxin or 2–6 h thereafter all had significantly higher white cell counts 24 h after endotoxin infusion. A second dose of endotoxin given 24 h after the first caused a rapid fall in white cell count, and no difference between the groups could then be observed 2 h later.The most striking effect was observed when methylprednisolone was administered simultaneously with the endotoxin. This caused a suppression of the clearance of endotoxin from the circulation, and this in turn could probably account for some newly synthesized thromboplastin expressed by the circulating monocytes. Furthermore, monocyte activation appears to be significantly higher in the animals receiving steroids than in the controls when the animals are subjected to two doses of endotoxin injections 24 h apart. Thus, high doses of methylprednisolone cannot be seen to have any beneficial effect as judged from the parameters tested in the present study.

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“…In the present study, the procoagulant activity generated in response to incubation with endotoxin enhanced the clotting time offactor IX-deficient plasma, but not that of factor X-deficient plasma. This indicated that the procoagulant activity generated by leukemic cells was TF activity, and was neither a direct prothrombin activator nor a direct activator of factor X, substances which have been reported to be synthesized by endotoxin-stimulated macrophages (21,22).…”

Section: Discussionmentioning

confidence: 97%