Production of cephalosporin C in a fluidized-bed bioreactor

Park, Young Hoon; Kim, Eui Yong; Seo, Weon Taek; Jung, Kyung Hee; Yoo, Y J

doi:10.1016/0922-338x(89)90146-3

Cited by 18 publications

(1 citation statement)

References 9 publications

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“…Earlier studies also indicated that high mass transfer rates and antibiotic production is possible from fluidized bed bioreactors. Liquid as the continuous phase has been used for the production of cephalosporin C [11], penicillin [12] and streptomycin [13], gentamicin [9] in fluidized bed reactor (FBR), and oxytetracycline in air bubbled reactor [7].…”

Section: Introductionmentioning

confidence: 99%

Continuous Production of Oxytetracycline in Fluidized Bed Bioreactor by Immobilized Cells of Streptomyces varsoviensis MTCC-1537: Effect of Dilution and Glucose Loading Rates

Jetty

Potumarthi

Rao

et al. 2009

Appl Biochem Biotechnol

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Oxytetracycline (OT) production using glutaraldehyde cross-linked calcium alginate immobilized cells of Streptomyces varsoviensis in continuous fluidized bed reactor (FBR) was investigated. Initially, batch experiments were carried in stirred tank reactor (STR) and FBR using calcium alginate immobilized cells. Higher OT production of 0.45 gm/L was achieved by FBR when compared with 0.33 g/L of OT in STR. All subsequent studies were carried out in continuous mode of operation in FBR. During 21 days of operation, effect of glucose concentration and different dilution rates were studied. A maximum of 0.75 g/L OT was achieved in the medium having 10 g/L of glucose concentration. The highest OT concentration of 0.92 g/L and the highest yield of OT with respect to biomass at 0.1713 g/g were obtained at the dilution rate of 0.25 day(-1).

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Section: Introductionmentioning

confidence: 99%

Continuous Production of Oxytetracycline in Fluidized Bed Bioreactor by Immobilized Cells of Streptomyces varsoviensis MTCC-1537: Effect of Dilution and Glucose Loading Rates

Jetty

Potumarthi

Rao

et al. 2009

Appl Biochem Biotechnol

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Continuous production of a hybrid antibiotic byStreptomyces lividans TK21 pellets in a three-phase fluidized-bed bioreactor

Sarrà

Casas

Gòdia

1997

Biotechnol. Bioeng.

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The continuous production of a hybrid antibiotic by a transformed strain of Streptomyces lividans TK21 in a three‐phase fluidized bed is studied. Cell aggregates, known as pellets, are used as immobilized cell particles in the bioreactor. A methodology to prepare pellets of a suitable size and morphology is developed. The continuous production of the antibiotic is studied on the basis of decoupling cell growth and antibiotic production, by means of phosphate limitation in the growth medium. The best results are achieved at D = 0.021 h1, with alternate feeding of 0 and 0.05 m M phosphate media. Continuous production of the antibiotic can be maintained at satisfactory levels for periods of 60 days, and stable operation of the bioreactor is achieved during 85 days. Finally, the evolution of the internal structure of the pellets during continuous fermentation is studied. © 1997 John Wiley & Sons, Inc. Biotechnol Bioeng 53: 601–610, 1997.

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Applications of Biofilm Reactors for Production of Value‐Added Products by Microbial Fermentation

Demirci¹,

Pongtharangkul²,

Pometto³

2006

Biofilms in the Food Environment

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Production of cephalosporin C in a fluidized-bed bioreactor

Cited by 18 publications

References 9 publications

Continuous Production of Oxytetracycline in Fluidized Bed Bioreactor by Immobilized Cells of Streptomyces varsoviensis MTCC-1537: Effect of Dilution and Glucose Loading Rates

Continuous Production of Oxytetracycline in Fluidized Bed Bioreactor by Immobilized Cells of Streptomyces varsoviensis MTCC-1537: Effect of Dilution and Glucose Loading Rates

Continuous production of a hybrid antibiotic byStreptomyces lividans TK21 pellets in a three-phase fluidized-bed bioreactor

Applications of Biofilm Reactors for Production of Value‐Added Products by Microbial Fermentation

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