Production of copper-64 using a hospital cyclotron: targetry, purification and quality analysis

Abstract

Supplemental Digital Content is available in the text.

Imaging zinc trafficking in vivo by positron emission tomography with zinc-62

“…64 Cu was produced as previously reported 35 in the form of copper-64 chloride ([ 64 Cu]CuCl 2 ) in 0.1 M HCl solution. [ 64 Cu]CuCl 2 (∼100 MBq, 200 μl) was concentrated to dryness under N 2 at 100°C for 10 min and the residue dissolved in 0.25% trisodium citrate (1 ml) to give [ 64 Cu]Cu-citrate at a final pH of 6.…”

Versatile Diphosphine Chelators for Radiolabeling Peptides with 99mTc and 64Cu

“…64 Cu was produced by a 64 Ni­(p,n) 64 Cu nuclear reaction on a CTI RDS 112 11 MeV cyclotron and purified to give 64 Cu 2+ in 0.1 M HCl solutions used for radiolabeling. , The 64 Cu 2+ solutions (in 0.1 M HCl) were dried under a flow of N 2 with heating at 100 °C, and the residue was redissolved in an ammonium acetate solution (0.1 M, pH 7). An aliquot of an ammonium acetate solution containing 64 Cu 2+ (10 MBq, 50–100 μL) was added to either DP Ph -PSMAt (50 μg) or DP Tol -PSMAt (50 μg) dissolved in an aqueous ammonium acetate (0.1 M) to give a final radiolabeling solution of 200 μL volume.…”

An Overview of In Vitro Assays of 64Cu-, 68Ga-, 125I-, and 99mTc-Labelled Radiopharmaceuticals Using Radiometric Counters in the Era of Radiotheranostics

“…Currently, the PET imaging radiopharmaceuticals used in the clinical setting to detect amyloid β (Aβ) peptide aggregations in the brains of Alzheimer’s patients contain only 18 F [ 18 , 36 , 37 , 38 ] and 11 C, which, unfortunately, both have too-short half-lives. One of the fields of application of research on the optimization of radiopharmaceuticals labeled with 64 Cu is to find bifunctional chelators for this radioisotope that are useful for detecting Aβ plaques.…”