Production of Corneal Lesions Using High-Intensity Focused Ultrasound

Ar, Rutzen; Cw, Roberts; Driller, J.; Gomez, Dulce H.; Bc, Lucas; Fl, Lizzi; Dj, Coleman

doi:10.1097/00003226-199010000-00010

Cited by 10 publications

(7 citation statements)

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“…In ophthalmology, HIFU for the treatment of glaucoma and ultrasonic drug delivery are the two main areas of research and potential clinical application [ 10 ]. Nevertheless, HIFU keratoplasty was first described in 1990 by Rutzen et al [ 17 ] as a theoretical option for inducing collagen shrinkage in corneas. They commented that HIFU could be used to heat the peripheral cornea with great precision because of the small focal zone and the excellent aiming capabilities of HIFU.…”

Section: Discussionmentioning

confidence: 99%

“…In recent years, several experimental and clinical studies for the treatment of glaucoma have been conducted [ 10 – 15 ]. Although several studies have addressed the effects of HIFU on the cornea in the 1980s and 1990s [ 16 , 17 ], nowadays HIFU has more advantages, such as controlled accuracy, accuracy of positioning in the treatment area, and smaller focal zones [ 11 – 13 ]. Furthermore, a higher operating frequency allows for a steeper transition between the focal zone and the untreated area, thus reducing the risk of heating the neighboring healthy tissue [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

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Keratorefractive Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Eyes

Yan²,

Luo

et al. 2016

Journal of Ophthalmology

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Purpose. To evaluate high intensity focused ultrasound (HIFU) as an innovation and noninvasive technique to correct presbyopia by altering corneal curvature in the rabbit eye. Methods. Eighteen enucleated rabbit eyes were treated with a prototype HIFU keratoplasty. According to the therapy power, these eyes were divided three groups: group 1 (1 W), group 2 (2 W), and group 3 (3 W). The change in corneal power was quantified by a Sirius Scheimpflug camera. Light microscopy (LM) and transmission electron microscopy (TEM) were performed to determine the effect on the corneal stroma. Results. In the treated eyes, the corneal curvature increases from 49.42 ± 0.30 diopters (D) and 48.00 ± 1.95 D before procedure to 51.37 ± 1.11 D and 57.00 ± 1.84 D after HIFU keratoplasty application in groups 1 and 3, respectively. The major axis and minor axis of the focal region got longer when the powers of the HIFU got increased; the difference was statistically significant (p < 0.05). LM and TEM showed HIFU-induced shrinkage of corneal stromal collagen with little disturbance to the underlying epithelium. Conclusions. We have preliminarily exploited HIFU to establish a new technique for correcting presbyopia. HIFU keratoplasty will be a good application prospect for treating presbyopia.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Keratorefractive Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Eyes

Yan²,

Luo

et al. 2016

Journal of Ophthalmology

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“…Korneayı ısıtmak için termokeratoforlar, lazer, mikrodalga, ultrason enerjisi ve radyofrekans gibi farklı termal enerji kaynakları kullanılabilmektedir. [5][6][7][8][9][10][11] Olgumuzda oluşan kollajen çekintisi medikal tedavi ile takip edildi. İzlem süresince gelişen astigmatizmanın çekintinin azalması ile doğru orantılı olarak yavaş yavaş düzeldiği saptandı.…”

Section: Kornea Biyomekanik öZellikleri 30-50unclassified

Corneal Collagen Shrinkage That Occured Secondary to Hot Metal Contact: Case Report

Donbaloğlu¹,

Oltulu²,

Şatırtav³

et al. 2015

Turkiye Klinikleri J Ophthalmol

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190K orneanın termal hasarının kollajen çekintisine yol açtığı ve korneanın o bölgede kırıcılık gücünü değiştirdiği bilinmektedir.1 Korneanın bir kısmının ısıtılarak kollajen çekintisi oluşturulması 1889 yılından beri terapötik amaçlı kullanılmaktadır.1 Korneada kollajen çekintisi oluşturarak tedavi amaçlı uygulanan ve bu alanda en iyi bilinen teknik, lazer termal keratoplasti (TKP) uygulamasıdır. Göze temas hâlinde sıcak metale bağlı yanıklar, kalıcı skarla sonuçlanan korneal yaralanmalara yol açmaktadır.2 Isı Sıcak Metal Temasına İkincil Gelişen Kollajen Çekintisi Ö ÖZ ZE ET T Kırk altı yaşındaki erkek olgu, sağ gözüne sıcak metal teması sonucu görme azlığı, ağrı ve kı-zarıklık nedeni ile kliniğimize başvurdu. Olgunun oftalmolojik muayenesinde sağ göz görme keskinliği tashihli 1/10, biyomikroskobik muayenede kornea nazal yarısında epitel defekti, kollajen çekintisi ve konjonktiva dokusunda nekroz mevcut idi, sol göz doğal olarak değerlendirildi. Kornea topografisi erken dönemde optimal bir değerlendirme yapılamadı, otorefraktometre ölçümlerinde yüksek astigmatizma geliştiği gözlemlendi. Sıcak metal temasına ikincil korneal yanık tanısı ile medikal tedavisi uygulandı, kornea epitel defekti kapanıncaya kadar günlük takibe alındı. Kornea çe-kintisindeki düzelme ile orantılı olarak görme keskinliğinde artma izlendi. Sıcak metal teması ile meydana gelen kornea çekintisi durumunda, semptomatik tedavi ile olgumuzda yaklaşık bir yıl gibi bir süre zarfında anatomik ve fonksiyonel olarak tam iyileşme sağlandı. Bu çalışmada, sağ gözüne sıcak metal teması sonucu kornea kollajen çekintisi gelişen bir olgunun medikal tedavi ile uzun süre takipte tamamen iyileştiğini vurgulamayı amaçladık.A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Kollajen; yaralanmalar; metaller A AB BS S T TR RA AC CT T Forty six years-old male patient applied to our clinic with hot metal contact to right eye caused vision loss, pain and hyperemia. Corrected visual acuity was 1/10 in the right eye, biomicroscopic examination revealed that epithelial defect and collagen shrinkage at nasal quadrant of cornea, conjunctival necrosis in the nasal quadrant of right eye, left eye was normal. Corneal topography could not be evaluated optimal in early period, auto refractometry results revealed that developing high astigmatism. Medical therapy was applicated with diagnosis of corneal burn seconder hot metal contact, daily following was taken up until epithelial of healing is complete. Visual acuity was proportionally increased with the amelioration of the collagen shrinkage. Corneal collagen shrinkage of secondary to hot metal contact with good approach and symptomatic therapy has shown that exact anatomic and functional healing in patients at about one year. In this report, we purpose to emphasized that complete healing of corneal collagen shrinkage of secondary to hot metal contact to right eye with medical treatment at long-term follow up.

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“…1990), microwave (TREMBLY and KEATES, 1991) or ultrasound (RUTZEN et al, 1990 et al, 2000). In OUr study, in two eyes, the lesions had different depths along the circular pattern.…”

Section: Medical and Biological Engineering And Computing 2003 Vol 41mentioning

confidence: 99%

Ring electrode for radio-frequency heating of the cornea: Modelling andin vitro experiments

Berjano

Sáiz

Alió

et al. 2003

Med. Biol. Eng. Comput.

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Radio-frequency thermokeratoplasty (RF-TKP) is a technique used to reshape the cornea curvature by means of thermal lesions using radio-frequency currents. This curvature change allows refractive disorders such as hyperopia to be corrected. A new electrode with ring geometry is proposed for RF-TKP. It was designed to create a single thermal lesion with a full-circle shape. Finite element models were developed, and the temperature distributions in the cornea were analysed for different ring electrode characteristics. The computer results indicated that the maximum temperature in the cornea was located in the vicinity of the ring electrode outer perimeter, and that the lesions had a semi-torus shape. The results also indicated that the electrode thickness, electrode radius and electrode thermal conductivity had a significant influence on the temperature distributions. In addition, in vitro experiments were performed on rabbit eyes. At 5 W power, the lesions were fully circular. Some lesions showed non-uniform characteristics along their circular path. Lesion depth depended on heating duration (60% of corneal thickness for 20 s, and 30% for 10 s). The results suggest that the critical shrinkage temperature (55-63 degrees C) was reached at the central stroma and along the entire circular path in all the cases.

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Production of Corneal Lesions Using High-Intensity Focused Ultrasound

Cited by 10 publications

References 0 publications

Keratorefractive Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Eyes

Keratorefractive Effect of High Intensity Focused Ultrasound Keratoplasty on Rabbit Eyes

Corneal Collagen Shrinkage That Occured Secondary to Hot Metal Contact: Case Report

Ring electrode for radio-frequency heating of the cornea: Modelling andin vitro experiments

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