Production of curcumin-resveratrol cocrystal using cocrystallization with supercritical solvent

Magro, Camila Dal; Santos, Aline Elias dos; Ribas, Marcela M.; Aguiar, Gean Pablo S.; Volfe, Carolin Roberta Bueno; Lopes, Maria L.L.C.; Siebel, Anna Maria; Müller, Liz Girardi; Bortoluzzi, Adaílton J.; Lanza, Marcelo; Oliveira, J. Vladimir

doi:10.1016/j.supflu.2021.105190

Cited by 26 publications

(9 citation statements)

References 53 publications

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“…4a). 46 The FTIR spectrum of crystalline PIP appeared as distinct absorption bands at 2937 and 2857 cm −1 due to the C–H stretching from the benzene ring and the methylenedioxy group, at 1634 cm −1 due to the stretching of the CO group, and at 1584 cm −1 for the stretching vibration of C–N on the nitrogen heterocyclic ring (Fig. 4b).…”

Section: Resultsmentioning

confidence: 99%

Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system

Han

Qian

et al. 2022

CrystEngComm

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Section: Resultsmentioning

confidence: 99%

Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system

Han

Qian

et al. 2022

CrystEngComm

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“…In the supercritical uid processing method, MCCs are formed by dissolving APIs and coformers with a high-pressure supercritical uid (for example, the commonly used CO 2 ) in a stainless steel vessel (Thayyil et al, 2020) . This was applied in producing CUR cocrystals using resveratrol as a coformer (Dal Magro et al, 2021) . In addition, the antisolvent cocrystallization method uses an organic solvent or bu er as an antisolvent to dissolve coformers that will disperse with the APIs and other substances dissolved in the antisolvent.…”

Section: Solution-based MCC Preparation Methodsmentioning

confidence: 99%

“…Based on the solubility analysis, CUR-RSV cocrystals showed higher solubility of CUR and RSV in water, PBS (phosphate bu er solution), and 0.1 M HCl medium. The inference of solubility and dissolution pro le enhancement is in uenced by reduction of solids interaction, weaker crystalline structure, smaller particle size, and higher coformer solubility (Dal Magro et al, 2021) .…”

Section: Curcumin (Cur)mentioning

confidence: 99%

Crystal Engineering Approach in Physicochemical Properties Modifications of Phytochemical

Lutfiyah

Fitriani

Taher

et al. 2022

Sci. Technol. Indones

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Phytochemicals have been used to reduce the risk of diseases and maintain good health and well-being. However, most phytochemicals have a limitation in their physicochemical properties, which can be modified by reforming the shape of the crystals. Therefore, crystal engineering is a promising approach to optimize physicochemical characteristics of the active pharmaceutical ingredients (APIs) in a phytochemical without altering its pharmacological efficacy. Hence, this paper reviews current strategies for the use of crystal engineering to optimize physicochemical properties of phytochemicals, which is followed by the design of the synthesis and characterization of particular phytochemicals, including piperine (PIP), quercetin (QUE), curcumin (CUR), genistein (GEN), and myricetin (MYR). The literature indicates that crystal engineering of multicomponent crystals (MCCs) enhances phytochemical physicochemical properties, including solubility, dissolution rate, stability, and permeability. The MCCs provide a lower lattice energy and noncovalent bonding, which translate into lower melting points and weak intermolecular interactions that generate greater solubility, higher dissolution rate, and better stability of the APIs. Nevertheless, the absence of reported studies of phytochemical crystal engineering leads to a lack of variation in the selection of coformers, methods of preparation, and improvement of physicochemical properties. Therefore, more extensive evaluation of the design and physicochemical characteristics of phytochemicals using MCCs is necessary and manifests the opportunity to enhance the application of phytochemicals in the pharmaceutical industry.

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“…By this technique the RES-CUC co-crystal was successfully obtained. The results obtained from experiments show that it can be used as antiinflammatory, antioxidant and anti-nociceptive agent [58].…”

Section: Pip + Resmentioning

confidence: 99%

Bioactive Compounds from Plants Used as Therapeutic Agents in Biomedical Applications – a Literature Review –

PALTINEAN¹,

Riga²,

Tomoaia³

et al. 2021

AnnalsARSciBio

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This review proposes an extensive study of some bioactive compounds produced by plants (piperine - PIP, curcumin - CUC, resveratrol – RES, icariin - ICA) with beneficial effects on human health. In addition to these compounds, the need for natural pigments, carotenoids in the body's daily diet and implicitly in nano-science and medicine is also debated. This study points to complexes of proactive compounds as well as their interaction with other drugs (e.g., doxorubicin: DOX, 5-fluorouracil: 5-FLU, paclitaxel: PCT) and metal nanoparticles (such as: gold nanoparticles: GNP, AuNP, and silver nanoparticles: SNP, AgNP) with applications in cancer cell lines and bacterial investigation, as well as using viral and fungal strains. This study also opens new opportunities of multi-functional metallic nanoparticles, realized by self-assemblies through molecular recognition among bioactive compounds on GNP or SNP, for their biomedical applications that require continuous development in terms of infections and the need to treat cancer and other diseases.

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Production of curcumin-resveratrol cocrystal using cocrystallization with supercritical solvent

Cited by 26 publications

References 53 publications

Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system

Self-gelation involved in the transformation of resveratrol and piperine from a co-amorphous system into a co-crystal system

Crystal Engineering Approach in Physicochemical Properties Modifications of Phytochemical

Bioactive Compounds from Plants Used as Therapeutic Agents in Biomedical Applications – a Literature Review –

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