Production of drug-releasing biodegradable microporous scaffold impregnated with gemcitabine using a CO2 foaming process

Álvarez, Ignacio; Gutiérrez, C.; Rodrı́guez, Juan F.; Lucas, Antonio de; Garcı́a, Marı́a Teresa

doi:10.1016/j.jcou.2020.101227

Cited by 20 publications

(9 citation statements)

References 72 publications

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“…The rate of the drug release proved to be dependent on the solubility of rutin in the medium as well as on the morphology of the foams that had been obtained, since it has an influence on the way the polymer is eroded and diluted in the fluid [ 39 ]. The release process is also affected by the degradation and diffusion of the polymer through the matrix where the drug is distributed [ 16 ]. These characteristics will be affected by variations in pressure, temperature, depressurization rate, or polymer LA:GA ratio.…”

Section: Resultsmentioning

confidence: 99%

“…PLGA has been used in locally implanted medical devices, including scaffolds for controlled drug release and to enhance drug bioavailability in tissue repairing processes [ 15 ]. The studies conducted have achieved the impregnation of gemcitabine in PLGA foams from ethyl lactate solutions of gemcitabine [ 16 ], mesoporous bioactive glass particles (MBGs) have been incorporated into PLGA [ 17 ], PLGA composite foams were produced using phosphate glass particles as filler [ 18 ], thymol has been impregnated into PLGA for controlled release [ 19 ] and bioactive lipids have been incorporated to PLGA scaffolds [ 20 ]. In some cases, such as bone tissue repair, the action of the drug is to be prolonged for as long as months.…”

Section: Introductionmentioning

confidence: 99%

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Determining the Optimal Conditions for the Production by Supercritical CO2 of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment

et al. 2021

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Poly(D,L,-lactide-co-glycolide) (PLGA) foam samples impregnated with rutin were successfully produced by supercritical foaming processes. A number of parameters such as pressure (80–200 bar), temperature (35–55 °C), depressurization rate (5–100 bar/min), ratio lactide:glycolide of the poly(D,L,-lactide-co-glycolide) (50:50 and 75:25) were studied to determine their effect on the expansion factor and on the glass transition temperature of the polymer foams and their consequences on the release profile of the rutin entrapped in them. The impregnated foams were characterized by scanning electron microscopy, differential scanning calorimetry, and mercury intrusion porosimetry. A greater impregnation of rutin into the polymer foam pores was observed as pressure was increased. The release of rutin in a phosphate buffer solution was investigated. The controlled release tests confirmed that the modification of certain variables would result in considerable differences in the drug release profiles. Thus, five-day drug release periods were achieved under high pressure and temperature while the depressurization rate remained low.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determining the Optimal Conditions for the Production by Supercritical CO2 of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment

et al. 2021

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“…The anticancer gemcitabine was impregnated in foam scaffolds fabricated using PLGA as a polymer and supercritical CO 2 as the pressurizing gas where the scaffolds possessed very high impregnation efficiency (>90%) [154].…”

Section: Gas Foamingmentioning

confidence: 99%

Conventional and Recent Trends of Scaffolds Fabrication: A Superior Mode for Tissue Engineering

ElMeligy

2022

Pharmaceutics

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Tissue regeneration is an auto-healing mechanism, initiating immediately following tissue damage to restore normal tissue structure and function. This falls in line with survival instinct being the most dominant instinct for any living organism. Nevertheless, the process is slow and not feasible in all tissues, which led to the emergence of tissue engineering (TE). TE aims at replacing damaged tissues with new ones. To do so, either new tissue is being cultured in vitro and then implanted, or stimulants are implanted into the target site to enhance endogenous tissue formation. Whichever approach is used, a matrix is used to support tissue growth, known as ‘scaffold’. In this review, an overall look at scaffolds fabrication is discussed, starting with design considerations and different biomaterials used. Following, highlights of conventional and advanced fabrication techniques are attentively presented. The future of scaffolds in TE is ever promising, with the likes of nanotechnology being investigated for scaffold integration. The constant evolvement of organoids and biofluidics with the eventual inclusion of organ-on-a-chip in TE has shown a promising prospect of what the technology might lead to. Perhaps the closest technology to market is 4D scaffolds following the successful implementation of 4D printing in other fields.

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“…These ophthalmic devices maintained adequate therapeutic levels for a longer period and overcame the limitations that were associated with conventional ocular drug formulations (32)(33)(34). In addition, the scCO2-assisted impregnation process has been used to prepare drug-containing biomedical implants, such as sutures (5,35), scaffolds for tissue engineering (36,37), stents, and endoprosthesis to decrease the infection risks and increase tissue regeneration (5). A variety of polymers, such as polyesters, polysaccharides, cellulose, silicon-based copolymers, polyurethane, etc., have been used as drug carriers.…”

Section: Impregnation Of Drugs Into Polymersmentioning

confidence: 99%

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

Milovanović¹,

Lukić²

2022

Arhiv za farmaciju

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Supercritical carbon dioxide (scCO2) application in the pharmaceutical industry is still undeveloped regardless of significant research interests in this processing medium shown in the last decades. ScCO2 technologies can improve drug solubility, bioavailability, and therapeutic effect. These technologies can lead to the development of new formulations that will contribute to a decrease in drug dose, medication frequency, and increase patients' well-being. Considering the significant decrease in the price of high-pressure equipment and society's growing need for cleaner production and safer products, it is expected that symbiosis between supercritical fluid and pharmaceutical technologies will happen soon. Therefore, this review was focused on the latest contributions of scCO2 technologies to the pharmaceutical field. The main aim was to bring these technologies closer to pharmaceutical specialists. For this purpose, the most commonly used technologies were explained and discussed: the preparation of solid dispersions, polymer impregnation with drugs, and drug micro/nanoparticle production using scCO2.

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Production of drug-releasing biodegradable microporous scaffold impregnated with gemcitabine using a CO2 foaming process

Cited by 20 publications

References 72 publications

Determining the Optimal Conditions for the Production by Supercritical CO2 of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment

Determining the Optimal Conditions for the Production by Supercritical CO2 of Biodegradable PLGA Foams for the Controlled Release of Rutin as a Medical Treatment

Conventional and Recent Trends of Scaffolds Fabrication: A Superior Mode for Tissue Engineering

An overview on the application of supercritical carbon dioxide for the processing of pharmaceuticals

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