Production of encapsulated quercetin particles using supercritical fluid technologies

Lévai, György; Martín, Ángel; Moro, Alberto; Matias, Ana A.; Gonçalves, V.S.S.; Bronze, Maria Rosário; Duarte, Catarina M.M.; Rodríguez‐Rojo, Soraya; Cocero, Marı́a José

doi:10.1016/j.powtec.2017.04.041

Cited by 28 publications

(12 citation statements)

References 35 publications

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“…Many works have been carried out to study the application of SFEE for the production of encapsulated compounds in foods [ 82 , 114 , 137 , 138 , 139 ]. Prieto et al [ 137 ] used SFEE to encapsulate fish oil rich in omega-3 polyunsaturated fatty acids in polycaprolactone as carried material.…”

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

“…Overall, all the studies published so far claimed the advantages of SFEE technique to provide microencapsulated compounds with high encapsulation efficiencies, narrow particle size distribution with spherical and non-aggregated morphologies [ 82 , 137 ].…”

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

“…Recently, Levai et al [ 82 ] produced microparticles of quercetin encapsulated by SFEE then subsequently dried by PGSS. A comparison was also carried out by drying the product by freeze-drying.…”

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

“…Moreover, the PGSS dried quercetin microparticles reported an enhanced permeability through the transdermal membrane into a simulated intestinal fluid compared to the freeze-dried microparticles. This conferred a higher potential to the microparticles produced with the combination of SFEE and PGSS-drying in terms of functional properties [ 82 ].…”

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

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Novel Technologies Based on Supercritical Fluids for the Encapsulation of Food Grade Bioactive Compounds

Klettenhammer

Ferrentino

Morozova

et al. 2020

Foods

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In recent years, the demand for nutritive, functional and healthy foods has increased. This trend has induced the food industry to investigate novel technologies able to produce ingredients with enhanced functional and physicochemical properties. Among these technologies, one of the most promising is the encapsulation based on supercritical fluids. Thanks to the inherent absence of organic solvent, the low temperature of the process to reach a supercritical state and the capacity to dissolve lipid soluble bioactives, the encapsulation with supercritical carbon dioxide represents a green technology to produce several functional ingredients, with enhanced stability, high load and tailored protection from environmental factors. Furthermore, from the fine-tuning of the process parameters like temperature, pressure and flow rate, the resulting functional ingredient can be easily designed to tailor the controlled release of the bioactive, or to reach specific levels of taste, odor and color. Accordingly, the aim of the present review is to summarize the state of the art of the techniques based on supercritical carbon dioxide for the encapsulation of bioactive compounds of food interest. Pros and cons of such techniques will be highlighted, giving emphasis to their innovative aspects that could be of interest to the food industry.

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Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

Section: Supercritical Carbon Dioxide Technologies For the Encapsumentioning

confidence: 99%

See 2 more Smart Citations

Novel Technologies Based on Supercritical Fluids for the Encapsulation of Food Grade Bioactive Compounds

Klettenhammer

Ferrentino

Morozova

et al. 2020

Foods

View full text Add to dashboard Cite

show abstract

“…To modify bioavailability of quercetin through microencapsulation More homogenous lyophilized less crystalline encapsulated quercetin particles were reported with enhanced bioavailability [65] β-carotene, poly-(εcaprolactone) β-carotene was encapsulated in polycaprolactones, and precipitated out using PGSS process.…”

Section: Pgss For Particle Generationmentioning

confidence: 99%

Supercritical fluid technology for solubilization of poorly water soluble drugs via micro- and naonosized particle generation

Misra

Pathak

2020

ADMET DMPK

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<p class="ADMETabstracttext">Approximately two-third of the compounds in the pharmaceutical industry were developed through combinatorial chemistry and high throughput screening of particulate solids. Poor solubility and bioavailability of these pharmaceuticals are challenging attributes confronted by a formulator during product development. Hence, substantial efforts have been directed into the research on particle generation techniques. Although the conventional methods, such as crushing or milling and crystallization or precipitation, are still used; supercritical fluid technology introduced in the mid-1980s presents a new method of particle generation. Supercritical fluid processes not only produce micro- and nanoparticles with a narrow size distribution, they are also employed for the microencapsulation, cocrystallization, and surface coating with polymer. Recognized as a green technology, it has emerged as successful variants chiefly as Rapid Expansion of supercritical solutions (RESS), Supercritical anti-solvent (SAS) and Particles from Gas Saturated Solution (PGSS) depending upon type of solvent, solute, antisolvent and nebulization techniques. Being economical and eco-friendly, supercritical fluid technolgy has garnered considerable interest both in academia and industry for modification of physicochemical properties such as particle size, shape, density and ultimately solubility. The current manuscript is a comprehensive update on different supercritical fluid processes used for particle generation with the purpose of solubility enhancement of drugs and hence bioavailability.</p>

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Progress in Supercritical Fluid Technology for Fats and Oils Processing

Temelli

Güçlü‐Üstündağ

Couto

2020

Bailey's Industrial Oil and Fat Products

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Supercritical CO 2 (SC‐CO 2 ) processing of fats and oils has been widely investigated since SC‐CO 2 offers an environmentally friendly alternative with added advantages such as moderate operating conditions and solvent‐free extracts and residues. From a processing perspective, a unique advantage of SC‐CO 2 processing lies in its versatility, which results from the ability to modify solvent properties by changing operating conditions (temperature and pressure) or by the addition of cosolvents. A good understanding of the fundamentals of solubility behavior of lipid components in SC‐CO 2 as affected by operating conditions and solute properties is required to realize its full potential in fats and oils processing. The operational flexibility offered by supercritical fluid technology enables the processor to fine‐tune solvent properties and to develop novel processes by the integration of unit operations of extraction, fractionation, reaction, and particle formation to meet the process objectives. These unit operations have been effectively utilized for the extraction and refining of oils, concentration of bioactive components from oils or oil by‐products, modification of the physical properties of fats and oils, production of oleochemicals and design of delivery systems for numerous applications.

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Production of encapsulated quercetin particles using supercritical fluid technologies

Cited by 28 publications

References 35 publications

Novel Technologies Based on Supercritical Fluids for the Encapsulation of Food Grade Bioactive Compounds

Novel Technologies Based on Supercritical Fluids for the Encapsulation of Food Grade Bioactive Compounds

Supercritical fluid technology for solubilization of poorly water soluble drugs via micro- and naonosized particle generation

Progress in Supercritical Fluid Technology for Fats and Oils Processing

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