Production of Fatty Acids and Derivatives by Metabolic Engineering of Bacteria

Mehrer, Christopher R.; Lozada, Néstor J. Hernández; Lai, Rung‐Yi; Pfleger, Brian F.

doi:10.1007/978-3-319-50436-0_385

Cited by 1 publication

(2 citation statements)

References 89 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Exploiting fatty acid biosynthesis for fuel production is advantageous, as many species have high carbon flux into these energy rich chemicals. Large increases in yields have been achieved in fatty acid and fatty acid-derived chemicals (reviewed in Mehrer et al (2016)) and similar methods can be applied to increasing alkane biosynthesis efficiencies. There are early examples of this being applied successfully to microbial production of alkanes.…”

Section: Pathway Engineeringmentioning

confidence: 99%

See 1 more Smart Citation

Alkane Biosynthesis in Bacteria

Brown

Loh

Aves

et al. 2018

Biogenesis of Hydrocarbons

View full text Add to dashboard Cite

Biofuels are a commercial reality with ethanol comprising approximately 10% of the US retail fuel market, and biodiesels contribute a little under 5% to the EU retail fuel market. These biofuels molecules are derived from the fermentation of sugars by yeast (ethanol), and from the chemical modification of animal fats and plant oils (biodiesel). However, these biofuel molecules are chemically distinct from the petroleum fuels that they are blended with. Petroleum-based fuels are predominantly composed of alkane and alkene hydrocarbons. These differences impact on fuel properties and infrastructure compatibility resulting in a 'blend wall' that -without significant infrastructure re-alignment and associated costs -limits the use of biofuels. For this reason, there is great interest in biosynthetic routes for alkane and alkene production. Here we will review the known biological routes to alka/ene biosynthesis with a focus on bacterial alkane and alkene biosynthetic pathways. Specifically, we will review pathways for which the underlying genetic components have been identified. We will also investigate the development of engineered metabolic pathways that permit the production of alkanes and alkenes that are not Page 2 of 19 naturally synthesised in bacteria (heterologous production), but are suitable for industrial commercial application.Finally, we will highlight some of the challenges facing this research area as it moves from proof-of-principle studies towards industrialisation.

show abstract

Section: Pathway Engineeringmentioning

confidence: 99%

“…The biosynthesis of other hydrocarbon molecules, for example isoprenoids, will not be considered here, nor will we review the extensive literature manipulating and enhancing fatty acid biosynthesis. For reviews on these topics see Schrader and Bohlmann (2015) and Mehrer et al (2016) respectively.…”

Section: Introductionmentioning

confidence: 99%