Production of Functionally Active Recombinant Proteins in Plants

Castilho, Alexandra; Strasser, Richard

doi:10.1002/9781118801512.ch4

Cited by 2 publications

(1 citation statement)

References 140 publications

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“…Transcription activator-like effector nucleases (TALENs) have also been used to knockout XylT and FucT genes in an attempt to reduce such an undesired immunogenic response 83 . The development of modern genome editing tools may lead to the introduction of whole glycosylation pathways to produce therapeutic proteins in plants with defined human N - and O -glycan patterns 84 . The production of therapeutic proteins in plants also reduces the risk of potential contamination with animal pathogens (prions, viruses, and mycoplasmas).…”

Section: Heterologous Expression Of Therapeutic Proteins In Plantsmentioning

confidence: 99%

Medicinal Plants: Guests and Hosts in the Heterologous Expression of High-Value Products

Vasil'ev

2021

Planta Med

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Medicinal plants play an important dual role in the context of the heterologous expression of high-value pharmaceutical products. On the one hand, the classical biochemical and modern omics approaches allowed for the discovery of various genes encoding biosynthetic pathways in medicinal plants. Recombinant DNA technology enabled introducing these genes and regulatory elements into host organisms and enhancing the heterologous production of the corresponding secondary metabolites. On the other hand, the transient expression of foreign DNA in plants facilitated the production of numerous proteins of pharmaceutical importance. This review summarizes several success stories of the engineering of plant metabolic pathways in heterologous hosts. Likewise, a few examples of recombinant protein expression in plants for therapeutic purposes are also highlighted. Therefore, the importance of medicinal plants has grown immensely as sources for valuable products of low and high molecular weight. The next step ahead for bioengineering is to achieve more success stories of industrial-scale production of secondary plant metabolites in microbial systems and to fully exploit plant cell factoriesʼ commercial potential for recombinant proteins.

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Section: Heterologous Expression Of Therapeutic Proteins In Plantsmentioning

confidence: 99%

Medicinal Plants: Guests and Hosts in the Heterologous Expression of High-Value Products

Vasil'ev

2021

Planta Med

View full text Add to dashboard Cite

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Molecular Farming for the Production of Recombinant Pharmaceutical Proteins in Plants

Fidan,

Secgin

2024

Concepts and Strategies in Plant Sciences

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Production of Functionally Active Recombinant Proteins in Plants

Cited by 2 publications

References 140 publications

Medicinal Plants: Guests and Hosts in the Heterologous Expression of High-Value Products

Medicinal Plants: Guests and Hosts in the Heterologous Expression of High-Value Products

Molecular Farming for the Production of Recombinant Pharmaceutical Proteins in Plants

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