Production of highly pure no-carrier added 89Zr for the labelling of antibodies with a positron emitter

Routine Production of 89Zr Using an Automated Module

“…This separation can produce high recovery, radionuclidic purity, and effective specific activity (ESA). Our work does not contribute new separation chemistry; rather, the objective for this work was to automate the process that was reported by Holland, et al [23] based on chemistry that was developed by Verel, et al [24], Meijs, et al [25], and Herscheid, et al [39].…”

“…This separation has been performed with mixed results using several different techniques [23], including solvent extraction [21,22,26,27,37], solid cation exchange [21,22], solid anion exchange [22,26,27,38], and solid hydroxamate resin [23][24][25]39,40]. Hydroxamate resin separation has emerged as the preferred method following the publication of a standardized method for producing and separating 89 Zr by Holland, et al [23].…”

“…Fortunately, high radionuclidic purity can still be achieved using ~15 MeV protons because 89m Zr has a short half-life (t 1/2 = 4.2 m) and a high degree of isomeric transition (IT = 93.8%) and because the (p,2n) and (p,pn) reactions require greater proton beam energies, so they have low cross-sections at E p~1 5 MeV-less than 0.2 and 0.02 b, respectively [19]. The important characteristics of 89 Zr production in general are summarized in Table 2, and the parameters and results from eight publications [20][21][22][23][24][25][26][27] about 89 Zr production are shown in the ESI. 88 Zr contaminant, while still producing 89 Zr [19,[28][29][30][31][32][33][34][35][36].…”

“…Out of eight papers that used the (p,n) reaction for 89 Zr production, five used Y foil targets [20,21,23,26,27], two used sputtered Y onto Cu [24,25], and one used Y 2 O 3 pellets [22]. Although the sputtered targets provided superior heat transfer and therefore allowed for higher beam currents, we chose to use Y foil for ease of use.…”

An automated system for production of [sup 89]Zr

“…1 89 Zr can be produced on a biomedical cyclotron from a yttrium (Y) target via the 89 Y(p,n) 89 Zr reaction. While 89 Zr can be separated from the target material by anion exchange chromatography, 2 Meijs et al 3 achieved improved recovery and radionuclidic purity using a hydroxamate resin that Herscheid et al 4 had previously used for the purification of a different radionuclide. More recently, Holland et al 1 standardized the overall process for 89 Zr production using a hydroxamate resin column.…”