Production of interleukin‐5, ‐10 and interferon‐γ in cord blood is strongly associated with the season of birth

Keski‐Nisula, Leea; Lappalainen, Mikko; Mustonen, Kirsi; Hirvonen, Maija-Riitta; Pfefferle, Petra Ina; Renz, Harald; Pekkanen, Juha; Roponen, Marjut

doi:10.1111/j.1365-2222.2010.03601.x

Cited by 15 publications

(11 citation statements)

References 59 publications

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“…Lundholm et al [105] demonstrated that increasing birth weight is a risk factor for AD, but not AR, clearly independent of gestational age, shared environmental and genetic factors. This indicates that fetal growth affects the immune system and points to early mechanisms in line with evidence from many birth cohort studies [79, 106–111]. Thomsen et al [112] confirmed the strong genetic component of asthma in children and adults, and that this may not extend to older adults.…”

Section: Epidemiology Of Allergic Diseasessupporting

confidence: 64%

“…Indeed, in frame of the LINA (Lifestyle and environmental Factors and their influence on Newborns Allergy risk) study, reduced frequencies of Treg cells together with Th2 cytokines IL‐4 and IL‐5 levels in blood collected at the 34th week of gestation correlated with increased IgE levels in cord blood [50]. Other immune determinants than maternal factors are, however, involved in cord blood: the stronger predictor of IL‐5, IL‐10 and IFN‐γ production in cord blood is the season of birth, with a higher level of cytokine production in spring vs. fall [79]. Still in cord blood, some mediators such as selected chemokines could serve as biomarkers predictive of atopic diseases.…”

Section: Mechanisms In Allergic Diseasementioning

confidence: 99%

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Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy

Katelaris

Linneberg

Magnan

et al. 2011

Clin Experimental Allergy

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In 2010 over 200 articles were published in Clinical and Experimental Allergy including editorials, reviews, opinion articles, letters, book reviews and of course at the heart of the journal, papers containing original data which have moved the field of allergy forward on a number of fronts. For the third year running the editors felt it would be of value to summarize the key messages contained in these papers as a snapshot of where the cutting edge of research into allergic disease is leading. We have broadly followed the sections of the journal, although this year the mechanistic articles are grouped together and the studies involving experimental models of disease are discussed throughout the paper. In the field of asthma and rhinitis phenotypes and biomarkers continue to a major pre-occupation of our authors. There is continued interest in mechanisms of inflammation and disordered lung function with the mouse model of asthma continuing to offer new insights. There is also a steady flow of papers investigating new therapies, including those derived from plants and herbs, although many are mechanistic with too few high quality clinical trials. The mechanisms involved in allergic disease are well covered with many strong papers using clinical material to ask relevant questions. Pro-pre and snybiotics continue to be of major interest to our authors and this remains a controversial and complicated field. The discipline of epidemiology has retained its interest in risk factors for the development of allergic disease with a view to refining and debating the reasons for the allergy epidemic. There is continued interest in the relationship between helminthic disease and allergy with a new twist in 2010 involving studies using infection with helminths as a potential treatment. The genetics of allergic disease continues to be very productive, although the field has moved on from only investigating single nucleotide polymorphisms of candidate genes to Genome Wide Association Studies and an increasing and welcome emphasis on gene-environment interactions. In the field of clinical allergy there is steady flow of papers describing patterns of drug allergy with renewed interest in reactions to contrast media, but food allergy is the major area of interest in this section of the journal. Lastly in the field of allergens there is a growing interest in the role of component resolved diagnosis in improving the diagnosis and management of allergic disease. Another excellent year, full of fascinating and high quality work, which the journal has been proud to bring to the allergy community.

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Section: Epidemiology Of Allergic Diseasessupporting

confidence: 64%

Section: Mechanisms In Allergic Diseasementioning

confidence: 99%

Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy

Katelaris

Linneberg

Magnan

et al. 2011

Clin Experimental Allergy

View full text Add to dashboard Cite

show abstract

“…The PCA is described in details in the Supplemental Digital Content 1, http://links.lww.com/INF/C406. All associations were adjusted for gender [21][22][23] and season of birth. [23][24][25] All statistical analysis are based on a linear quasipoison regression, while in the graphical presentation of the results, the children are partitioned into 3 groups based on the number of LRI.…”

Section: Methodsmentioning

confidence: 99%

Susceptibility to Lower Respiratory Infections in Childhood is Associated with Perturbation of the Cytokine Response to Pathogenic Airway Bacteria

Vissing

Larsen

Rasmussen

et al. 2016

Pediatric Infectious Disease Journal

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“…The season in which a person is born influences their risk of allergic disease: those born in autumn and winter typically have higher risks of developing many allergic diseases including food allergy. This is also manifested at the immunological level, as exemplified by season of birth being the strongest predictor of cytokine production in cord blood cells . The primary stimuli underlying the season of birth effect on allergic disease are unknown, but may include ultraviolet light/vitamin D levels, pollen and viral infection timing, and seasonal variations in nutrition.…”

Section: In Utero Exposures That Influence Allergymentioning

confidence: 99%

Does allergy begin in utero?

Lockett

Huoman

Holloway

2015

Pediatric Allergy Immunology

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It has been recognized for centuries that allergic disease runs in families, implying a role for genetic factors in determining individual susceptibility. More recently, a range of evidence shows that many of these genetic factors, together with in utero environmental exposures, lead to the development of allergic disease through altered immune and organ development. Environmental exposures during pregnancy including diet, nutrient intake and toxin exposures can alter the epigenome and interact with inherited genetic and epigenetic risk factors to directly and indirectly influence organ development and immune programming. Understanding of these factors will be essential in identifying at-risk individuals and possible development of therapeutic interventions for the primary prevention of allergic disease. In this review, we summarize the evidence that suggests allergic disease begins in utero, together with possible mechanisms for the effect of environmental exposures during pregnancy on allergic disease risk, including epigenetics.

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Production of interleukin‐5, ‐10 and interferon‐γ in cord blood is strongly associated with the season of birth

Cited by 15 publications

References 59 publications

Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy

Developments in the field of allergy in 2010 through the eyes of Clinical and Experimental Allergy

Susceptibility to Lower Respiratory Infections in Childhood is Associated with Perturbation of the Cytokine Response to Pathogenic Airway Bacteria

Does allergy begin in utero?

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