Production of Iodine-123 for medical applications

Hupf, H.B.; Eldridge, J. S.; Beaver, J.E.

doi:10.1016/0020-708x(68)90178-6

Cited by 58 publications

(7 citation statements)

References 1 publication

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“…Although the admixture composed of aluminum powder and enriched elemental tellurium-124 has been previously reported [6,7] as an effective combination for the cyclotron production of iodine-123, tellurium dioxide was chosen as the appropriate target material for the production of iodine-124 because of its better thermal characteristics over tellurium metal. The combination of tellurium dioxide with aluminum oxide offered an effective binding agent and resulted in the formation of the glassy solid solution target without the need for cover foils.…”

Section: Resultsmentioning

confidence: 99%

Low energy cyclotron production and chemical separation of "no carrier added" iodine-124 from a reusable, enriched tellurium-124 dioxide/aluminum oxide solid solution target

Sheh¹,

Koziorowski²,

Balatoni³

et al. 2000

Radiochimica Acta

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Tellurium dioxide / Iodine-124 / Dry distillation / PET Summary. Iodine-124 is a radionuclide with a 4.18 day halflife which decays by positron emission (23.3%) and electron capture (76.7 %). Details on the preparation of this radionuclide via the 124 Te(p,n) 124 I nuclear reaction are described. A reusable target uniquely suited for low energy cyclotron irradiations has been described along with specific characteristics for the dry distillation recovery of the 124 I species.

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Section: Resultsmentioning

confidence: 99%

Low energy cyclotron production and chemical separation of "no carrier added" iodine-124 from a reusable, enriched tellurium-124 dioxide/aluminum oxide solid solution target

Sheh¹,

Koziorowski²,

Balatoni³

et al. 2000

Radiochimica Acta

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“…El-Azony and Qaim [22], on the other hand, developed an anionexchange method for the separation of 123 I from a 123 Te metal target irradiated with protons to produce 123 I via the 123 Te(p,n)-reaction [cf. 23,24]. A somewhat similar method was used for the separation of 131 I formed in the decay of 131 Te [25].…”

Section: Introductionmentioning

confidence: 99%

Development of an ion-exchange method for separation of radioiodine from tellurium and antimony and its application to the production of 124I via the 121Sb(α,n)-process

Hassan

Spellerberg

Schölten

et al. 2014

J Radioanal Nucl Chem

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A novel anion-exchange chromatographic method for separation of radioiodine from an antimony target irradiated with 3 He-or a-particles was developed, with separation yield of radioiodine amounting to 90 ± 5 % and its decontamination factor from the Te and Sb radionuclides to *10 4 . The optimized separation method developed was then applied to the production of 124 I via the 121 Sb(a,n) 124 I process using a highly enriched 121 Sb target. Quality control tests showed that the separated 124 I occurred [99 % as iodide and the longer lived impurities 126 I and 125 I amounted to 0.16 % and \0.05 %, respectively. The trace level of inactive Sb impurity was determined by ICP-OES.

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“…Many techniques have been used in imaging of the brain, either by direct or indirect methods . Iodine‐123 is the isotope of choice for medical imaging with a half‐life to 13.22 hours, and it decays by emission of gamma radiation with energy of 159 keV.…”

Section: Introductionmentioning

confidence: 99%

“…Iodine‐123 is the isotope of choice for medical imaging with a half‐life to 13.22 hours, and it decays by emission of gamma radiation with energy of 159 keV. However, its short half‐life and high cost necessitate that iodine‐125 was used to develop all parts of our research except the imaging part with used Iodine‐131 . Iodine‐131 is used in nuclear medicine therapeutically and can also be detected by diagnostic scanners.…”

Section: Introductionmentioning

confidence: 99%

Radioiodination and bioevaluation of rolipram as a tracer for brain imaging: In silico study, molecular modeling and gamma scintigraphy

Sanad

Farag

Salama

2018

Labelled Comp Radiopharmac

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Brain imaging is considered one of the most fruitful applications of radioisotope scanning. Rolipram, a selective phospodiesterase-4 inhibitor, has been labeled using [ I] with chloramine-T (Ch-T) as an oxidizing agent. Factors, such as the amount of substrate, pH, the amount of oxidizing agent, temperature, and the reaction time, have been systematically studied to optimize the iodination process. In addition, bio-distribution studies have indicated that the brain uptake of [ I]iodorolipram is 7.6 ± 0.33 injected dose/g organ at 10 minutes post-injection, which cleared from the brain with time until it reaches 1.30 ± 0.17% at 1 hour post-injection. Therefore, iodorolipram could be considered as a potential, new selective radiotracer for brain imaging.

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Production of Iodine-123 for medical applications

Cited by 58 publications

References 1 publication

Low energy cyclotron production and chemical separation of "no carrier added" iodine-124 from a reusable, enriched tellurium-124 dioxide/aluminum oxide solid solution target

Low energy cyclotron production and chemical separation of "no carrier added" iodine-124 from a reusable, enriched tellurium-124 dioxide/aluminum oxide solid solution target

Development of an ion-exchange method for separation of radioiodine from tellurium and antimony and its application to the production of 124I via the 121Sb(α,n)-process

Radioiodination and bioevaluation of rolipram as a tracer for brain imaging: In silico study, molecular modeling and gamma scintigraphy

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