Production of itaconic acid by biotransformation of wheat bran hydrolysate with Aspergillus terreus CICC40205 mutant

Wu, Xuefeng; Liu, Qing; Deng, Yong‐Dong; Li, Jinghong; Chen, Xiaoju; Gu, Yuan Dong; Lv, Xijun; Zheng, Zhi; Jiang, Shaotong; Li, Xingjiang

doi:10.1016/j.biortech.2017.05.080

Cited by 51 publications

(14 citation statements)

References 40 publications

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“…Production of IA was investigated by the biotransformation from WB hydrolysate. The IA yield was further increased by utilizing the A. terreus mutant strain CICC40205 [94].…”

Section: Other Acids Production Utilizing Wb As a Sourcementioning

confidence: 99%

A Sight to Wheat Bran: High Value-Added Products

et al. 2019

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Recently more consideration has been given to the use of renewable materials and agricultural residues. Wheat production is increasing yearly and correspondingly, the volume of by-products from the wheat process is increasing, as well. It is important to find the use of the residuals for higher value-added products, and not just for the food industry or animal feed purposes as it is happening now. Agricultural residue of the roller milled wheat grain is a wheat bran description. The low-cost of wheat bran and its composition assortment provides a good source of substrate for various enzymes and organic acids production and other biotechnological applications. The main purpose of this review article is to look into recent trends, developments, and applications of wheat bran.

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“…Production of IA was investigated by the biotransformation from WB hydrolysate. The IA yield was further increased by utilizing the A. terreus mutant strain CICC40205 [94].…”

Section: Other Acids Production Utilizing Wb As a Sourcementioning

confidence: 99%

A Sight to Wheat Bran: High Value-Added Products

et al. 2019

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“…However, D -glucose and D -xylose as well as D -xylose and L -arabinose partially interfere with each other’s uptake and metabolism, and thus investigation of their combined conversion will only yield scientifically valid data if the metabolism of these sugars in the absence of the others is understood first. Consequently, studies on IA production from D -xylose have actually been performed decades ago (Eimhjellen and Larsen, 1955; Kautola et al, 1985; Kautola, 1990), and re-initiated in recent years (Saha et al, 2017, 2019; Wu et al, 2017; Saha and Kennedy, 2019).…”

Section: Introductionmentioning

confidence: 99%

Manganese Deficiency Is Required for High Itaconic Acid Production From D-Xylose in Aspergillus terreus

et al. 2019

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Itaconic acid is used as a bio-based, renewable building block in the polymer industry. It is produced by submerged fermentations of the filamentous fungus Aspergillus terreus from molasses or starch, but research over the efficient utilization of non-food, lignocellulosic plant biomass is soaring. The objective of this study was to test whether the application of two key cultivation parameters for obtaining itaconic acid from D -glucose in high yields – Mn 2+ ion deficiency and high concentration of the carbon source – would also occur on D -xylose, the principal monomer of lignocellulose. To this end, a carbon and energy balance for itaconic acid formation was established, which is 0.83 moles/mole D -xylose. The effect of Mn 2+ ions on itaconic acid formation was indeed similar to that on D -glucose and maximal yields were obtained below 3 μg L –1 Mn 2+ ions, which were, however, only 0.63 moles of itaconic acid per mole D -xylose. In contrast to the case on D -glucose, increasing D -xylose concentration over 50 g L –1 did not change the above yield. By-products such as xylitol and α-ketoglutarate were found, but in total they remained below 2% of the concentration of D -xylose. Mass balance of the fermentation with 110 g L –1 D -xylose revealed that >95% of the carbon from D -xylose was accounted as biomass, itaconic acid, and the carbon dioxide released in the last step of itaconic acid biosynthesis. Our data show that the efficiency of biomass formation is the critical parameter for itaconic acid yield from D -xylose under otherwise optimal conditions.

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“…Among the tested carbon sources, glucose remarkably promoted cell growth but negligibly promoted enzyme productivity, whereas tannin efficiently improved tannase production and biomass accumulation. Although a consensus exists that glucose increases microbial cell growth [ 32 ], the role of glucose in tannase production through SSF remains controversial. For example, Beniwal et al [ 20 ] observed that supplementation with glucose represses tannase production; however, Rodrigues et al [ 33 ] indicated that glucose does not adversely affect enzyme production.…”

Section: Discussionmentioning

confidence: 99%

Novel optimization strategy for tannase production through a modified solid-state fermentation system

Zhang

et al. 2018

Biotechnol Biofuels

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BackgroundHigh amounts of insoluble substrates exist in the traditional solid-state fermentation (SSF) system. The presence of these substrates complicates the determination of microbial biomass. Thus, enzyme activity is used as the sole index for the optimization of the traditional SSF system, and the relationship between microbial growth and enzyme synthesis is always ignored. This study was conducted to address this deficiency. All soluble nutrients from tea stalk were extracted using water. The aqueous extract was then mixed with polyurethane sponge to establish a modified SSF system, which was then used to conduct tannase production. With this system, biomass, enzyme activity, and enzyme productivity could be measured rationally and accurately. Thus, the association between biomass and enzyme activity could be easily identified, and the shortcomings of traditional SSF could be addressed.ResultsDifferent carbon and nitrogen sources exerted different effects on microbial growth and enzyme production. Single-factor experiments showed that glucose and yeast extract greatly improved microbial biomass accumulation and that tannin and (NH4)2SO4 efficiently promoted enzyme productivity. Then, these four factors were optimized through response surface methodology. Tannase activity reached 19.22 U/gds when the added amounts of tannin, glucose, (NH4)2SO4, and yeast extract were 7.49, 8.11, 9.26, and 2.25%, respectively. Tannase activity under the optimized process conditions was 6.36 times higher than that under the initial process conditions. The optimized parameters were directly applied to the traditional tea stalk SSF system. Tannase activity reached 245 U/gds, which is 2.9 times higher than our previously reported value.ConclusionsIn this study, a modified SSF system was established to address the shortcomings of the traditional SSF system. Analysis revealed that enzymatic activity and microbial biomass are closely related, and different carbon and nitrogen sources have different effects on microbial growth and enzyme production. The maximal tannase activity was obtained under the optimal combination of nutrient sources that enhances cell growth and tannase accumulation. Moreover, tannase production through the traditional tea stalk SSF was markedly improved when the optimized parameters were applied. This work provides an innovative approach to bioproduction research through SSF.Electronic supplementary materialThe online version of this article (10.1186/s13068-018-1093-0) contains supplementary material, which is available to authorized users.

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Production of itaconic acid by biotransformation of wheat bran hydrolysate with Aspergillus terreus CICC40205 mutant

Cited by 51 publications

References 40 publications

A Sight to Wheat Bran: High Value-Added Products

A Sight to Wheat Bran: High Value-Added Products

Manganese Deficiency Is Required for High Itaconic Acid Production From D-Xylose in Aspergillus terreus

Novel optimization strategy for tannase production through a modified solid-state fermentation system

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