Production of malodorous steroids from androsta-5,16-dienes and androsta-4,16-dienes by Corynebacteria and other human axillary bacteria

Decréau, Richard A.; Marson, Charles M.; Smith, Kelvin E.; Behan, John M.

doi:10.1016/j.jsbmb.2003.09.005

Cited by 37 publications

(24 citation statements)

References 48 publications

(69 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Corynebacteria are extremely fastidious and slow-growing organisms in culture, and, as such, their role as skin microorganisms has been underappreciated until recently. Processing of apocrine sweat by corynebacteria and staphylococci (along with other axillary vault microorganisms) results in the characteristic malodour associated with sweat in humans 15,16,18,50 .…”

Section: Molecular Analysis Of Skin Microbiotamentioning

confidence: 99%

The skin microbiome

2011

View full text Add to dashboard Cite

The skin is the human body’s largest organ, colonized by a diverse milieu of microorganisms, most of which are harmless or even beneficial to their host. Colonization is driven by the ecology of the skin surface, which is highly variable depending on topographical location, endogenous host factors and exogenous environmental factors. The cutaneous innate and adaptive immune responses can modulate the skin microbiota, but the microbiota also functions in educating the immune system. The development of molecular methods to identify microorganisms has led to an emerging view of the resident skin bacteria as highly diverse and variable. An enhanced understanding of the skin microbiome is necessary to gain insight into microbial involvement in human skin disorders and to enable novel promicrobial and antimicrobial therapeutic approaches for their treatment.

show abstract

Section: Molecular Analysis Of Skin Microbiotamentioning

confidence: 99%

The skin microbiome

2011

View full text Add to dashboard Cite

show abstract

“…Culture-dependent analyses of the axilla microbiota has revealed microorganisms, namely the Corynebacterium , that process odorless eccrine, apocrine, and sebaceous gland secretions, thus producing volatile organic fatty acids and thioalcohols that are responsible for malodor associated with sweating of the axilla. 34-37 Sequencing of 16S rRNA genes has confirmed that Corynebacterium and Staphylococcus are the predominant axilla bacteria, with higher proportions of Corynebacterium in males, and those using deodorants harboring greater bacterial diversity. 38 Genetic variation in ABCC11 , specifically a 538G→A single nucleotide polymorphism (SNP) prevalent in East Asian populations, results in reduced concentration of axillary apocrine secretions and decreased production of axillary odor.…”

Section: Moist Skin: Body Odor and Atopic Dermatitismentioning

confidence: 98%

The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease

Grice¹

2014

Sem Cutan Med Surg

201

147

View full text Add to dashboard Cite

A vast diversity of microorganisms, including bacteria, fungi, viruses, and arthropods, colonize the human skin. Culture-independent genomic approaches for identifying and characterizing microbial communities have provided glimpses into the topographical, temporal, and interpersonal complexity that defines the skin microbiome. Identification of changes associated with cutaneous disease, including acne, atopic dermatitis, rosacea, and psoriasis, are being established. In this review, our current knowledge of the skin microbiome in health and disease is discussed, with particular attention to potential opportunities to leverage the skin microbiome as a diagnostic, prognostic, and/or therapeutic tool.

show abstract

“…Decréau et al. were able to show that steroids of the androsta‐5,16‐diene series are a major source of androsta‐4,16‐dien‐3‐one and, therefore, likely precursors of human malodour components [22]. Furthermore, the authors demonstrated that the stereochemistry of the precursor molecules determines the extent of malodour.…”

Section: Major Routes and Mechanisms Of Human Body Odour Formationmentioning

confidence: 99%

“…The analysis of biotransformation and the detection of intermediates allowed the prediction of enzyme functions involved in the process of body odour development. It is proposed that the interplay between 3α(β)‐sterol hydrogenase, 4, 5‐ or 5α‐reductase, steroid‐4,5‐isomerase and hydroxylases leads to the conversion of non‐odouriferous precursor molecules into odouriferous steroid derivatives [22]. No 5α‐reductase activity could be verified in vitro until now, but the requirement of a reductase system in the process of steroid biotransformation has been demonstrated [22, 25].…”

Section: Major Routes and Mechanisms Of Human Body Odour Formationmentioning

confidence: 99%

Molecular basis of human body odour formation: insights deduced from corynebacterial genome sequences

Barzantny

Brune

Tauch

2011

Intern J of Cosmetic Sci

View full text Add to dashboard Cite

SynopsisDuring the past few decades, there has been an increased interest in the essential role of commensal skin bacteria in human body odour formation. It is now generally accepted that skin bacteria cause body odour by biotransformation of sweat components secreted in the human axillae. Especially, aerobic corynebacteria have been shown to contribute strongly to axillary malodour, whereas other human skin residents seem to have little influence. Analysis of odoriferous sweat components has shown that the major odour-causing substances in human sweat include steroid derivatives, short volatile branched-chain fatty acids and sulphanylalkanols. In this minireview, we describe the molecular basis of the four most extensively studied routes of human body odour formation, while focusing on the underlying enzymatic processes. Considering the previously reported role of b-oxidation in odour formation, we analysed the genetic repertoire of eight Corynebacterium species concerning fatty acid metabolism. We particularly focused on the metabolic abilities of the lipophilic axillary isolate Corynebacterium jeikeium K411. Ré suméPendant les décennies passées, il ya eu un intérêt croissant pour le rôle essentiel des bactéries commensales de la peau dans la formation des odeurs du corps humain. Il est maintenant généralement admis que les bactéries de la peau sont à l'origine de ces odeurs corporelles par biotransformation de composants de la sueur axillaire. On a, en particulier, montré que les corynebacteria aérobiques contribuent fortement à l'odeur axillaire, tandis que d'autres rési-dents de la peau semblent avoir une influence moindre. L'analyse de composants odoriférants de la sueur a montré que les substances majoritairement responsables de l'odeur incluent des dérivées de stéroïdes, des acides gras volatils à courtes chaines et des sulphanylalcanols. Dans cette mini revue, nous décrivons les bases molécu-laires des quatre voies les plus largement étudiées dans la formation des odeurs corporelles, en nous concentrant sur les processus enzymatiques sous-jacents. En considérant le rôle précédemment décrit de la b oxydation dans la formation d'odeur, nous avons analysé le répertoire génétique de huit espèces de Corynebacterium concernant le métabolisme des acide gras. Nous nous sommes particulièrement concentrés sur les capacités métaboliques de Corynebacterium jeikeium K411 isolé de la composante lipophile axillaire.

show abstract

Production of malodorous steroids from androsta-5,16-dienes and androsta-4,16-dienes by Corynebacteria and other human axillary bacteria

Cited by 37 publications

References 48 publications

The skin microbiome

The skin microbiome

The skin microbiome: potential for novel diagnostic and therapeutic approaches to cutaneous disease

Molecular basis of human body odour formation: insights deduced from corynebacterial genome sequences

Contact Info

Product

Resources

About