Production of medical isotope 68Ge based on a novel chromatography separation technique and assembling of 68Ge/68Ga generator

Wang, Jieru; Gao, Ruiqin; Cao, Shiwei; Qin, Zhi; Mei, Lin; Huang, Qinggang; Yao, Ze

doi:10.1016/j.apradiso.2022.110599

Applied Radiation and Isotopes

2023

DOI: 10.1016/j.apradiso.2022.110599

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Production of medical isotope 68Ge based on a novel chromatography separation technique and assembling of 68Ge/68Ga generator

Jieru Wang

Ruiqin Gao

Shiwei Cao

et al.

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2024

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Production and radiochemical separation of ⁶⁸Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

Chattopadhyay,

Singha,

Ash

et al. 2024

Radiochimica Acta

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Gallium-68 [t 1/2: 67.7 min, β+ (89 %)] has application in PET imaging mainly for prostate cancer and neuroendocrine tumours. Gallium-68 is generally obtained from a 68Ge/68Ga generator. It is therefore an important task to prepare 68Ge (t 1/2 = 271 days) radiochemical for the manufacture of 68Ge/68Ga generator to cater for the needs of various nuclear medicine centres. Germanium-68 has been produced successfully after irradiation of indigenously developed Ga–Ni targets in a 30 MeV cyclotron and chemical processing of the irradiated targets using an indigenous semi-automated module. The Ga–Ni targets were prepared by an electroplating method. The 68Ge has been radiochemically separated from irradiated Ga–Ni targets using Sephadex G-25 column chromatography. The chemical separation yield and radionuclidic purity of 68Ge were about 70 % (n = 3) and about 98.3 % (n = 3), respectively.

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Production and radiochemical separation of ⁶⁸Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

Chattopadhyay,

Singha,

Ash

et al. 2024

Radiochimica Acta

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show abstract

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Production of medical isotope 68Ge based on a novel chromatography separation technique and assembling of 68Ge/68Ga generator

Cited by 1 publication

References 34 publications

Production and radiochemical separation of ⁶⁸Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

Production and radiochemical separation of ⁶⁸Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

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Production of medical isotope 68Ge based on a novel chromatography separation technique and assembling of 68Ge/68Ga generator

Cited by 1 publication

References 34 publications

Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

Production and radiochemical separation of 68Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

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Production and radiochemical separation of ⁶⁸Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron

Production and radiochemical separation of ⁶⁸Ge from irradiated Ga–Ni alloy target in 30 MeV cyclotron