Production of Members of the Blood Coagulation and Fibrinolysin Systems by the Isolated Perfused Liver.

Mattii, R; Ambrus, Julian L.; Sokal, Joseph E.; Mink, Irving B.

doi:10.3181/00379727-116-29161

Cited by 31 publications

(13 citation statements)

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“…The liver is the major site of synthesis of 11 blood coagulation proteins: r Factor I: fibrinogen [68]. r Factor II: prothrombin [69]. r Factor V: proaccelerin and labile factor [69].…”

Section: Prothrombin Timementioning

confidence: 99%

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Laboratory Tests

Herlong

Mitchell

2011

Schiff's Diseases of the Liver

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Key conceptsr Biochemical tests can be used to detect acute injury to the liver and chronic diseases of the liver before development of symptoms.r Elevations in serum levels of aminotransferases (aspartate aminotransferase and alanine aminotransferase) reflect hepatocellular injury and/or permeability of the liver cell membrane, but do not correlate with the extent of fibrosis or measures of metabolic functions of the liver.r An elevation of serum alkaline phosphatase occurs in response to intrahepatic cholestasis, extrahepatic obstruction of bile ducts, or infiltration of the liver with granulomatous inflammation, amyloidosis, or venous congestion.r The rate-limiting step in metabolism and disposition of bilirubin is the transport of conjugated bilirubin from the hepatocyte into the bile.An elevation in the conjugated (direct-reacting) fraction of bilirubin is evidence of intrahepatic cholestasis or extrahepatic obstruction of the bile ducts.r Serum levels of albumin may be low in patients with acute or chronic liver disease, but very often drop in response to the "acute phase response," making it difficult to evaluate hepatic metabolic function in clinical situations such as infection.r Although single laboratory tests are generally not useful in evaluating the severity of acute or chronic liver diseases, the use of mathematical equations combining tests may be effective as surrogate markers for the extent of fibrosis, steatosis, and inflammation as well as to predict the short-term prognosis in patients with liver disease.The use of laboratory tests is an important component of the assessment of patients with liver disease. With increasing frequency, elevations in the hepatic enzymes detected on routine screening tests provide the first evidence of liver disease in otherwise asymptomatic patients. In those patients with previously recognized hepatic dysfunction, laboratory tests can help establish the etiology of liver disease and provide valuable prognostic information. Rarely does a single test provide sufficient information to establish a diagnosis or assess severity of liver disease. A combination of tests such as serum bilirubin, albumin, aminotransferases, and alkaline phosphatase is sometimes referred to "liver function tests" or a "liver panel." These tests, in combination with the prothrombin time can provide an initial characterization of the etiology and severity of liver disease. However, one should recognize that the aminotransferases and alkaline phosphatase are tests that reflect hepatic injury not function. Traditionally liver diseases have been characterized as primarily hepatocellular or cholestatic based on the predominance of elevated aminotransferases or alkaline phosphatase. While an individual laboratory test may not provide a specific diagnosis, the pattern of abnormalities can suggest a general category of hepatic dysfunction. Although this distinction helps direct the initial evaluation there is often considerable overlap so that aggregating the diseases is less useful, as in the case...

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“…The liver is the major site of synthesis of 11 blood coagulation proteins: r Factor I: fibrinogen [68]. r Factor II: prothrombin [69]. r Factor V: proaccelerin and labile factor [69].…”

Section: Prothrombin Timementioning

confidence: 99%

“…r Factor II: prothrombin [69]. r Factor V: proaccelerin and labile factor [69]. r Factor VII: serum prothrombin conversion accelerator and stable factor [69].…”

Section: Prothrombin Timementioning

confidence: 99%

Laboratory Tests

Herlong

Mitchell

2011

Schiff's Diseases of the Liver

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“…The isolated rat liver generates the well-established vitamin K.-dependent factors: prothrombin and factors VII, IX, and X [3,5,6]. Other techniques, such as rat liver slices and liver homogenates, are confirmatory.…”

Section: Introductionmentioning

confidence: 84%

Generation of Coagulation Factors V, XI, and XII by the Isolated Rat Liver

Owen¹,

Bowie²

1977

Pathophysiol Haemos Thromb

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When isolated rat livers were perfused with platelet-free erythrocytes suspended in Tyrode’s solution containing 6% bovine serum albumin, the generation of factors V, XI, and XII was clearly demonstrable. On average, after 5 h of perfusion of a single liver, the concentrations in the perfusate (as a percentage of normal rat plasma) were about 6% for factor V, 8% for factor XI, and 5% for factor XII, compared with 20% for factor VII, which was used as the reference standard. When two livers were perfused, approximately twice these concentrations were achieved. When the properties of these factors in perfusate and plasma were compared, they agreed well except for differences in the celite adsorbability of factors XI and XII.

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“…The normal plasminogen levels observed among our eosinophilic subjects in this study should raise a question as to whether marrow eosinophils are really the site of plasminogen synthesis for blood plas minogen. Riddle and Barnhart [10] further demonstrated positive plasminogen in peri pheral eosinophils from inflammatory tis sues and exudate besides marrow eosino phils [2], The positive plasminogen in these particular eosinophils could, on the one hand, simply be an inside metabolism in the process of cell maturation and perhaps for their functions. Our present knowledge about eosinophils remains very limited [11].…”

Section: Resultsmentioning

confidence: 99%

“…In spite of this knowledge, very little has been achieved on the sites of organ syn thesis of plasminogen. I.iver and kidney ap parently did not synthesize plasminogen be cause the perfusate from the isolated liver perfusion showed no plasminogen activity [2] , and normal plasminogen levels were found both in anephric rats and anephric patients [3]. Barnhart and Riddle [4], by immunofluorescent study, were able to dem onstrate profibrinolysin or plasminogen in the marrow eosinophils, and none in the peripheral blood eosinophils.…”

Section: Introductionmentioning

confidence: 99%

Plasminogen Levels in Subjects with Eosinophilia

Visudhiphan¹,

Sungnate²,

Piankijagum³

1980

Acta Haematol

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Plasminogen determinations were performed in 98 normal volunteers and 50 subjects with eosinophilia. There was no significant difference in the plasminogen levels between these two groups. Since, increased eosinophils in the bone marrow of those eosinophilic subjects were also demonstrated. This observation should raise a question as to whether the eosinophils would really be the site of systemic plasminogen synthesis.

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Production of Members of the Blood Coagulation and Fibrinolysin Systems by the Isolated Perfused Liver.

Cited by 31 publications

References 1 publication

Laboratory Tests

Laboratory Tests

Generation of Coagulation Factors V, XI, and XII by the Isolated Rat Liver

Plasminogen Levels in Subjects with Eosinophilia

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