Production of micro- and nanoscale chitosan particles for biomedical applications

Jayasuriya, Ambalangodage C.

doi:10.1016/b978-0-08-100230-8.00008-x

Cited by 15 publications

(5 citation statements)

References 123 publications

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“…Moreover, the self-assembled polyelectrolyte block copolymers integrate the key characteristics of BCs, polyelectrolytes, and surfactants; hence, the ease of structural modification for these intriguing classes of macromolecules allows various possibilities for utilization as nanostructural delivery vehicles of drugs, proteins, peptides, and genes. These responsive nanoassemblies can deliver the therapeutic agents through electrostatic interactions, as discussed comprehensively in the following chapter [28,[46][47][48]. Protein-polymer bioconjugation comprises an approach that results in hybrid biomacromolecules that combine both the efficient and morphological features of synthetic polymers and natural proteins [49].…”

Section: Methodsmentioning

confidence: 99%

Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications

2022

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Over the last three decades, proteins and peptides have attracted great interest as drugs of choice for combating a broad spectrum of diseases, including diabetes mellitus, cancer, and infectious and neurological diseases. However, the delivery of therapeutic proteins to target sites should take into account the obstacles and limitations related to their intrinsic sensitivity to different environmental conditions, fragile tertiary structures, and short half-life. Polymeric nanostructures have emerged as competent vehicles for protein delivery, as they are multifunctional and can be tailored according to their peculiarities. Thus, the enhanced bioavailability and biocompatibility, the adjustable control of physicochemical features, and the colloidal stability of polymer-based nanostructures further enable either the embedding or conjugation of hydrophobic or hydrophilic bioactive molecules, which are some of the features of paramount importance that they possess and which contribute to their selection as vehicles. The present review aims to discuss the prevalent nanostructures composed of block copolymers from the viewpoint of efficient protein hospitality and administration, as well as the up-to-date scientific publications and anticipated applications of polymeric nanovehicles containing proteins and peptides.

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Section: Methodsmentioning

confidence: 99%

Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications

2022

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“…Chitosan surface area and particle size are important characteristics which are related to the porosity, pore volume and pore size distribution of the chitosan. Surface area and particle size are fundamental for adsorption applications, since accessible sites and a porous structure are required [ 114 , 115 ]. It is known that chitosan powders or flakes are non-porous materials which present a low surface area (lower than 10 m 2 g −1 ) [ 23 ].…”

Section: Chitosanmentioning

confidence: 99%

Recent Developments in Chitosan-Based Adsorbents for the Removal of Pollutants from Aqueous Environments

et al. 2021

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The quality of water is continuously under threat as increasing concentrations of pollutants escape into the aquatic environment. However, these issues can be alleviated by adsorbing pollutants onto adsorbents. Chitosan and its composites are attracting considerable interest as environmentally acceptable adsorbents and have the potential to remove many of these contaminants. In this review the development of chitosan-based adsorbents is described and discussed. Following a short introduction to the extraction of chitin from seafood wastes, followed by its conversion to chitosan, the properties of chitosan are described. Then, the emerging chitosan/carbon-based materials, including magnetic chitosan and chitosan combined with graphene oxide, carbon nanotubes, biochar, and activated carbon and also chitosan-silica composites are introduced. The applications of these materials in the removal of various heavy metal ions, including Cr(VI), Pb(II), Cd(II), Cu(II), and different cationic and anionic dyes, phenol and other organic molecules, such as antibiotics, are reviewed, compared and discussed. Adsorption isotherms and adsorption kinetics are then highlighted and followed by details on the mechanisms of adsorption and the role of the chitosan and the carbon or silica supports. Based on the reviewed papers, it is clear, that while some challenges remain, chitosan-based materials are emerging as promising adsorbents.

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“…Chitosan is a linear polysaccharide of D-glucosamie and N-acetyl-D-glucosamine, which is usually extracted from crustacean shells of the food processing industry [77]. Chitosan is an animal-based biopolymer with cationic nature, and because of the positive charges of amino groups, it becomes a cationic polyelectrolyte after being dissolved in acetic acid [78]. This cationic feature allows it to interact with chitosan and the negatively charged double layer of clay [79,80].…”

Section: Animal-derived Biopolymersmentioning

confidence: 99%

Biopolymers as Green Binders for Soil Improvement in Geotechnical Applications: A Review

et al. 2021

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Soil improvement using biopolymers has attracted considerable attention in recent years, with the aim to reduce the harmful environmental effects of traditional materials, such as cement. This paper aims to provide a review on the environmental assessment of using biopolymers as binders in soil improvement, biopolymer-treated soil characteristics, as well as the most important factors affecting the behavior of the treated soil. In more detail, environmental benefits and concerns about the use of biopolymers in soil improvement as well as biopolymer–soil interaction are discussed. Various geotechnical properties are evaluated and compared, including the unconfined compressive strength, shear strength, erosion resistance, physical properties, and durability of biopolymer-treated soils. The influential factors and soil and environmental conditions affecting various geotechnical characteristics of biopolymer-treated soils are also discussed. These factors include biopolymer concentration in the biopolymer–soil mixture, moisture condition, temperature, and dehydration time. Potential opportunities for biopolymers in geotechnical engineering and the challenges are also presented.

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Production of micro- and nanoscale chitosan particles for biomedical applications

Cited by 15 publications

References 123 publications

Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications

Polymeric Nanostructures Containing Proteins and Peptides for Pharmaceutical Applications

Recent Developments in Chitosan-Based Adsorbents for the Removal of Pollutants from Aqueous Environments

Biopolymers as Green Binders for Soil Improvement in Geotechnical Applications: A Review

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