Production of microalgae with high lipid content and their potential as sources of nutraceuticals

Udayan, Aswathy; Pandey, Ashutosh Kumar; Sirohi, Ranjna; Sreekumar, Nidhin; Sang, Byoung-In; Sim, Sung Jun; Kim, Jun Seok; Pandey, Ashok

doi:10.1007/s11101-021-09784-y

Cited by 101 publications

(42 citation statements)

References 188 publications

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“…Microalgae contain high-value nutrients [ 4 ]. Depending on species, the microalgae may produce several important lipids, and other oils [ 12 , 13 , 14 ]. Microalgae strains with high oil production capabilities are required for efficient biodiesel production [ 3 , 4 ].…”

Section: Introductionmentioning

confidence: 99%

Fe3O4-PEI Nanocomposites for Magnetic Harvesting of Chlorella vulgaris, Chlorella ellipsoidea, Microcystis aeruginosa, and Auxenochlorella protothecoides

Gerulová¹,

Kucmanová²,

Sanny³

et al. 2022

Nanomaterials

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Magnetic separation of microalgae using magnetite is a promising harvesting method as it is fast, reliable, low cost, energy-efficient, and environmentally friendly. In the present work, magnetic harvesting of three green algae (Chlorella vulgaris, Chlorella ellipsoidea, and Auxenochlorella protothecoides) and one cyanobacteria (Microcystis aeruginosa) has been studied. The biomass was flushed with clean air using a 0.22 μm filter and fed CO2 for accelerated growth and faster reach of the exponential growth phase. The microalgae were harvested with magnetite nanoparticles. The nanoparticles were prepared by controlled co-precipitation of Fe2+ and Fe3+ cations in ammonia at room temperature. Subsequently, the prepared Fe3O4 nanoparticles were coated with polyethyleneimine (PEI). The prepared materials were characterized by high-resolution transmission electron microscopy, X-ray diffraction, magnetometry, and zeta potential measurements. The prepared nanomaterials were used for magnetic harvesting of microalgae. The highest harvesting efficiencies were found for PEI-coated Fe3O4. The efficiency was pH-dependent. Higher harvesting efficiencies, up to 99%, were obtained in acidic solutions. The results show that magnetic harvesting can be significantly enhanced by PEI coating, as it increases the positive electrical charge of the nanoparticles. Most importantly, the flocculants can be prepared at room temperature, thereby reducing the production costs.

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Section: Introductionmentioning

confidence: 99%

Fe3O4-PEI Nanocomposites for Magnetic Harvesting of Chlorella vulgaris, Chlorella ellipsoidea, Microcystis aeruginosa, and Auxenochlorella protothecoides

Gerulová¹,

Kucmanová²,

Sanny³

et al. 2022

Nanomaterials

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“…The great potential of chlorella alga as microalgae have been demonstrated as a sustainable food supply to meet the population’s needs because of their considerable phyto additives and/or bio-active phytonutrients, lipid, carotenoid, and protein content [ 28 , 29 , 51 ]. Many studies have reported on using microalgae for therapeutic potential and their applications (e.g., [ 52 ]), including diabetes [ 53 ].…”

Section: Discussionmentioning

confidence: 99%

Functional Yogurt Fortified with Honey Produced by Feeding Bees Natural Plant Extracts for Controlling Human Blood Sugar Level

Prokisch

El-Ramady

Daróczi³

et al. 2022

Plants

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The human blood sugar level is important and should be controlled to avoid any damage to nerves and blood vessels which could lead to heart disease and many other problems. Several market-available treatments for diabetes could be used, such as insulin therapy, synthetic drugs, herbal drugs, and transdermal patches, to help control blood sugar. In a double-blind human study, four kinds of honey from bees fed on acacia, sea buckthorn, chlorella alga, and green walnut extracts were used in fortifying yogurt for controlling human blood sugar. The impact of a previously fortified honey was investigated on blood levels and other parameters of healthy individuals in a human study with 60 participants. The participants received 150 mL of yogurt mixed with 30 g of honey every morning for 21 days. Before and after the study period, the basic blood parameters were tested, and the participants filled out standardized self-report questionnaires. Acacia honey was the traditional honey used as a control; the special honey products were produced by the patented technology. The consumption of green walnut honey had a significant effect on the morning blood sugar level, which decreased for every participant in the group (15 people). The average blood sugar level at the beginning in the walnut group was 4.81 mmol L−1, whereas the value after 21 days was 3.73 mmol L−1. The total decrease level of the individuals was about 22.45% (1.08 mmol L−1). Concerning the sea buckthorn and chlorella alga-based honey product groups, there was no significant change in the blood sugar level, which were recorded at 4.91 and 5.28 mmol L−1 before treatment and 5.28 and 5.07 mmol L−1 after, respectively. In the case of the acacia honey group, there was a slight significant decrease as well, it was 4.77 mmol L−1 at the beginning and 4.27 mmol L−1 at the end with a total decrease rate of 10.48%. It could thus be concluded that the active ingredients of green walnut can significantly decrease the blood sugar level in humans. This study, as a first report, is not only a new innovative process to add herbs or healthy active ingredients to honey but also shows how these beneficial ingredients aid the honey in controlling the human blood sugar level.

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“…Microalgae produce fatty acids and exotic acyl lipids which do not occur usually in terrestrial plants. Initially, the key goal of microalgal lipids research was biodiesel production but these lipids can also be used as alternative nutritional sources or as nutraceuticals (Udayan et al 2022 ). The lipids’concentration in some microalgae species can range from 20 to 70% of the dried biomass (Chowdhury and Loganathan 2019 ).…”

Section: Microalgal Bioactive Compounds and Their Potential Biologica...mentioning

confidence: 99%

Microalgal bioactive metabolites as promising implements in nutraceuticals and pharmaceuticals: inspiring therapy for health benefits

et al. 2023

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The rapid increase in global population and shrinkage of agricultural land necessitates the use of cost-effective renewable sources as alternative to excessive resource-demanding agricultural crops. Microalgae seem to be a potential substitute as it rapidly produces large biomass that can serve as a good source of various functional ingredients that are not produced/synthesized inside the human body and high-value nonessential bioactive compounds. Microalgae-derived bioactive metabolites possess various bioactivities including antioxidant, anti-inflammatory, antimicrobial, anti-carcinogenic, anti-hypertensive, anti-lipidemic, and anti-diabetic activities, thereof rapidly elevating their demand as interesting option in pharmaceuticals, nutraceuticals and functional foods industries for developing new products. However, their utilization in these sectors has been limited. This demands more research to explore the functionality of microalgae derived functional ingredients. Therefore, in this review, we intended to furnish up-to-date knowledge on prospects of bioactive metabolites from microalgae, their bioactivities related to health, the process of microalgae cultivation and harvesting, extraction and purification of bioactive metabolites, role as dietary supplements or functional food, their commercial applications in nutritional and pharmaceutical industries and the challenges in this area of research. Graphical abstract

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Production of microalgae with high lipid content and their potential as sources of nutraceuticals

Cited by 101 publications

References 188 publications

Fe3O4-PEI Nanocomposites for Magnetic Harvesting of Chlorella vulgaris, Chlorella ellipsoidea, Microcystis aeruginosa, and Auxenochlorella protothecoides

Fe3O4-PEI Nanocomposites for Magnetic Harvesting of Chlorella vulgaris, Chlorella ellipsoidea, Microcystis aeruginosa, and Auxenochlorella protothecoides

Functional Yogurt Fortified with Honey Produced by Feeding Bees Natural Plant Extracts for Controlling Human Blood Sugar Level

Microalgal bioactive metabolites as promising implements in nutraceuticals and pharmaceuticals: inspiring therapy for health benefits

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