Production of ML-236B, and Inhibitor of 3-Hydroxy-3-methylglutaryl CoA Reductase, by<i>Penicillium citrinum:</i>Improvements of Strain and Culture Conditions

Hosobuchi, Masahiko; Shioiri, Tetsuya; Ohyama, Jo; Arai, Masatoshi; Iwado, Seigo; Yoshikawa, Hiroji

doi:10.1271/bbb.57.1414

Cited by 24 publications

(19 citation statements)

References 3 publications

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“…High-producing mutants of P. citrinum SANK18767 were generated as reported by Hosobuchi et al (1993b). SANK18767 and its derivatives SANK14275, S-1567, S-5808 and No.…”

Section: Methodsmentioning

confidence: 99%

“…41520 were used in this study (Abe et al, 2002c;Hosobuchi et al, 1993a, b). MBG3-8 liquid medium was used for nucleic acid isolation and measurement of ML-236B productivity as described (Hosobuchi et al, 1993b). About 10 7 spores were transferred to a 100-ml flask containing 10 ml of MBG3-8 medium and incubated at 24°C on a rotary shaker (210 rpm) for up to 12 days.…”

Section: Methodsmentioning

confidence: 99%

“…The mutants of ML-236B-producing strains have been generated through random screening using ultraviolet (UV) irradiation, N-methyl-NЈ-nitro-N-nitrosoguanidine (NTG) treatment and isolation of mutants with resistance to nystatin after mutagenesis (Hosobuchi et al, 1993b). The characteristics of the high-producing mutant No.…”

Section: Characteristics Of Strains and Ml-236b Productionmentioning

confidence: 99%

“…1. It has been shown that a suitable pH for ML-236B production is around 4 (Hosobuchi et al, 1993b). The pH curves of the higher producing mutants S-5808 and No.…”

Section: Characteristics Of Strains and Ml-236b Productionmentioning

confidence: 99%

“…Pravastatin sodium is being produced using two fermentation steps (Hosobuchi et al, 1993b). The first step is the production of ML-236B by P. citrinum.…”

Section: Introductionmentioning

confidence: 99%

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Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum

Abe

Baba²,

Suzuki³

et al. 2004

J. Gen. Appl. Microbiol.

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“…High-producing mutants of P. citrinum SANK18767 were generated as reported by Hosobuchi et al (1993b). SANK18767 and its derivatives SANK14275, S-1567, S-5808 and No.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Characteristics Of Strains and Ml-236b Productionmentioning

confidence: 99%

“…1. It has been shown that a suitable pH for ML-236B production is around 4 (Hosobuchi et al, 1993b). The pH curves of the higher producing mutants S-5808 and No.…”

Section: Characteristics Of Strains and Ml-236b Productionmentioning

confidence: 99%

“…Pravastatin sodium is being produced using two fermentation steps (Hosobuchi et al, 1993b). The first step is the production of ML-236B by P. citrinum.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum

Abe

Baba²,

Suzuki³

et al. 2004

J. Gen. Appl. Microbiol.

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Energy Metabolism, Microbial and Animal Cells

Butler

Sparling

1999

Encyclopedia of Bioprocess Technology

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Compactin?a review

Chakravarti

Sahai

2004

Applied Microbiology and Biotechnology

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Compactin, a hypocholesterolemic molecule, is a competitive inhibitor of 3-hydroxy-3-methyl-glutaryl (HMG)-CoA reductase, which is a regulatory enzyme for cholesterol biosynthesis. The structural similarity and high affinity of the acid form of compactin and HMG, the natural substrate of enzyme, results in specific and effective inhibition of this enzyme. Inhibition results in reduced levels of mevalonic acid in the body, leading to pleiotropic effects. Various fungi have been used for the commercial production of compactin. Using different strategies for improving production levels, yields have been increased to around 900 times of the amount originally produced. Recently, the gene sequence responsible for compactin production has been cloned and sequenced. This review deals with the chemistry, mode of action, pharmacology, biosynthesis, and production of compactin. A comparative study of various reports dealing with the production of compactin is also included.

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Production of ML-236B, and Inhibitor of 3-Hydroxy-3-methylglutaryl CoA Reductase, byPenicillium citrinum:Improvements of Strain and Culture Conditions

Cited by 24 publications

References 3 publications

Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum

Molecular basis of ML-236B production in the high-producing mutant No. 41520 of Penicillium citrinum

Energy Metabolism, Microbial and Animal Cells

Compactin?a review

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