Production of new antituberculosis drug and other medical preparations by electron beam treatment

Phagocytosis of Hybrid Molecular Nanosomal Compositions Containing Oxidized Dextrans Conjugated with Isonicotinic Acid Hydrazide by Macrophages

“…p<0.05 between groups 5 and 9, groups 1 and 3, and groups 10 and 12; p<0.01 between groups 1 and 2, groups 3 and 4, groups 5 and 6, groups 7 and 8, groups 9 and 10, groups 11 and 12; groups 1 and 9, groups 2 and 10, groups 6 and 10, groups 3 and 11, groups 4 and 12, groups 5 and 7, and groups 6 and 10. radiochemical exposure. They probably are responsible for lower stability of HMNC and more rapid dextrazide leakage from them [2,7,8]. The results of this study suggest that HMNC containing dextrazides synthesized from chemically oxidized dextran possess higher tropism to macrophages compared to HMNC containing dextrazides containing radiochemically oxidized dextrans and can be considered as a promising intracellular slow-release preparation for the therapy of tuberculosis.…”

“…The complex of oxidized dextran (OD) with HMNC demonstrated high antimycobacterial activity under experimental conditions [3]. OD solutions prepared using radiochemical technique can contain various peroxide admixtures [2,8] modulating OD biocompatibility. From a practical perspective, HMNC containing OD conjugated with BAS (e.g.…”

In Vitro Effect of Oxidized Dextrans on Peritoneal Cells

“…The carriers from oxidized dextrans (OD) hold much promise in this respect [6]. The chemical (treatment with periodic acid and salts) [3] and radiochemical methods of dextran oxidation (γ-irradiation) [5] differ in the technological complexity and purity of end products [4,7]. OD obtained by these methods can contain various admixtures [4], which modify dextran biocompatibility.…”

Effect of Oxidixed Dextrans on Oxidative and Metabolic Function of Mouse Peritoneal Macrophages In Vitro and In Vivo

“…Modified dextran is used as a carrier for targeted delivery of bioactive substances into target cells [6,8], primarily into phagocytes [7]. Modified dextrans change functional state of phagocytes, in particular, modulate their oxidative and metabolic function, which can have negative and positive consequences for the organism due to activation of the production of activated O 2 metabolites [2].…”