Production of Pharmaceutical Proteins in Solanaceae Food Crops

Rigano, Maria Manuela; Guzman, Giorgio De; Walmsley, Amanda Maree; Frusciante, Luigi; Barone, Amalia

doi:10.3390/ijms14022753

Cited by 33 publications

(26 citation statements)

References 106 publications

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“…Die ursprüngliche Vision von essbaren Impfungen, für die lediglich das Impf-Antigen enthaltene Obst verzehrt werden müsste, hat sich aufgrund des geringen Impf-Antigengehalts, der fehlenden Standardisierbarkeit der Dosis sowie der mangelnden ImpfAntigenstabilität, aber auch wegen der Schwierigkeit einer zielgenauen Verteilung als schwer umsetzbar erwiesen, sodass neben ihrer weiteren Erforschung -etwa in Kartoffeln und Tomaten (Rigano et al, 2013) (Yusibov et al, 2011). Für eine Vielzahl verschiedener Krankheiten wie Gebärmutterhalskrebs, Tuberkulose, Hepatits B, Cholera, HIV sowie Durchfallerkrankungen und viele weitere werden weltweit PMPs entwickelt.…”

Section: Plant Phenotypingunclassified

7. Themenbereich grüne Gentechnologie: Pflanzenzüchtung und Agrarwirtschaft

Müller‐Röber¹,

Marx-Stölting²

2015

Dritter Gentechnologiebericht

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Section: Plant Phenotypingunclassified

7. Themenbereich grüne Gentechnologie: Pflanzenzüchtung und Agrarwirtschaft

Müller‐Röber¹,

Marx-Stölting²

2015

Dritter Gentechnologiebericht

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“…A continued focus on improvements that directly benefit consumers will be important to the viability of biotech potato in the marketplace. In addition to agronomic and nutrition benefits described in this review, non-food applications of biotech potato for industrial, pharmaceutical, and veterinary purposes could also benefit consumers through decreased manufacturing costs and increased functionality of therapeutic molecules (review by Rigano et al 2013) or starch-derived polymers (Neumann et al 2005;Hühns et al 2009). As research continues to identify and address challenges associated with potato production, we predict a corresponding invention of products that will advance the industry.…”

Section: Future Prospectsmentioning

confidence: 99%

Biotech Potatoes in the 21st Century: 20 Years Since the First Biotech Potato

et al. 2015

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Potato is the world's most important vegetable crop, with nearly 400 million tons produced worldwide every year, lending to stability in food supply and socioeconomic impact. In general, potato is an intensively managed crop, requiring irrigation, fertilization, and frequent pesticide applications in order to obtain the highest yields possible. Important traits are easy to find in wild relatives of potato, but their introduction using traditional breeding can take 15-20 years. This is due to sexual incompatibility between some wild and cultivated species, a desire to remove undesirable wild species traits from adapted germplasm, and difficulty in identifying broadly applicable molecular markers. Fortunately, potato is amenable to propagation via tissue culture and it is relatively easy to introduce new traits using currently available biotech transformation techniques. For these reasons, potato is arguably the crop that can benefit most by modern biotechnology. The benefits of biotech potato, such as limited gene flow to conventionally grown crops and weedy relatives, the opportunity for significant productivity and nutritional quality gains, and reductions in production cost and environmental impact, have the potential to influence the marketability of newly developed varieties. In this review we will discuss current and past efforts to develop biotech potato varieties, traits that could be impacted, and the potential effects that biotech potato could have on the industry.Resumen La papa es el cultivo hortícola más importante en el mundo, con cerca de 400 millones de toneladas producidas a nivel mundial anualmente, acreditando la estabilidad en el suministro de alimentos e impacto socioeconómico. En general, la papa es un cultivo manejado intensivamente, que requiere riego, fertilización y aplicaciones frecuentes de plaguicidas para obtener los más altos rendimientos posibles. Los caracteres importantes son fáciles de encontrar en parientes silvestres de la papa, pero su introducción usando el mejoramiento tradicional puede llevar de 15 a 20 años. Esto es debido a la incompatibilidad sexual entre algunas especies silvestres y cultivadas, el deseo para eliminar características indeseables de las especies silvestres del germoplasma adaptado, y la dificultad en la identificación de marcadores moleculares aplicables ampliamente. Afortunadamente, la papa es receptiva a la propagación por cultivo de tejidos y es relativamente fácil la introducción de nuevos caracteres usando técnicas biotecnológicas de transformación actualmente disponibles. Por estas razones, la papa es probablemente el cultivo que se puede beneficiar mayormente por la biotecnología moderna. Los beneficios de la papa biotecnológica, como el flujo genético limitado a cultivos que se siembran convencionalmente y a los parientes como malezas, la oportunidad para productividad significativa y logros en calidad nutricional, y las reducciones en los costos de producción e impacto ambiental, tienen el potencial para influenciar la comercialización...

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“…Some genome re-engineering and epigenetic approaches can have tremendous potential through the suppression or decrease of protease activities. For example, RNA interference is capable of shifting the metabolism of a given host plant and can repress the silencers that inhibit the expression of transiently transformed genes (Arzola, Chen, Rattanaporn, Maclean, & McDonald, 2011;Hakkinen et al, 2013;Rigano, De Guzman, Walmsley, Frusciante, & Barone, 2013;Tremblay, Diao, Huner, Jevnikar, & Ma, 2011).…”

Section: Other Approaches Used To Improve Yield Productionmentioning

confidence: 99%

Untitled

2014

Plant Sci. Today

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Plant molecular pharming is a promising concept based on the large-scale production of recombinant proteins encompassing antibodies, vaccines, enzymes and peptides for human or veterinary uses and treatments. This new branch of the biopharmaceutical industry offers practical and safety advantages over other traditional production systems. In higher plants, the complex cellular machinery makes possible synthesis and posttranslational modifications of heterologous protein macromolecules. The limiting obstacle to using this system at an industrial scale is most often the low yield of the recombinant proteins produced in host plants. To improve production levels, many studies have been focusing on the choice of plant species, tissues, organs and cell suspension cultures and/or various upstream and downstream constituents in the expression cassette. New engineering technologies in plant molecular pharming have emerged that rely on the usefulness of using soybean agglutinin (SBA), hydrophobin, zein and elastin-like peptide tags which are employed to extract and purify recombinant proteins in

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Production of Pharmaceutical Proteins in Solanaceae Food Crops

Cited by 33 publications

References 106 publications

7. Themenbereich grüne Gentechnologie: Pflanzenzüchtung und Agrarwirtschaft

7. Themenbereich grüne Gentechnologie: Pflanzenzüchtung und Agrarwirtschaft

Biotech Potatoes in the 21st Century: 20 Years Since the First Biotech Potato

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