Production of Radionuclides

Saha, Gopal B.

doi:10.1007/978-3-319-57580-3_4

Cited by 4 publications

(1 citation statement)

References 10 publications

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“…Today, more than 2700 radionuclides have been produced artificially with particle accelerators [15]. In addition, a few examples are also being obtained in loco using radionuclide generators through radioactive decay.…”

Section: Cyclotrons and The Production Of Unconventional Radionuclidesmentioning

confidence: 99%

Cyclotron Production of Unconventional Radionuclides for PET Imaging: the Example of Titanium-45 and Its Applications

et al. 2018

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Positron emitting radionuclides are used to label different compounds, allowing the study of the major biological systems using PET (positron emission tomography) imaging. Although there are several radionuclides suited for PET imaging, routine clinical applications are still based on a restrict group constituted by 18 F, 11 C, and, more recently, 68 Ga. However, with the enlarged availability of low-energy cyclotrons and technical improvements in radionuclide production, the use of unconventional radionuclides is progressively more common. Several examples of unconventional radionuclides for PET imaging are being suggested, and 45 Ti could be suggested as a model, due to its interesting properties such as its abundant positron emission (85%), reduced positron energy (β + endpoint energy = 1040 keV), physical half-life of 3.09 h, and interesting chemical properties. This review aims to introduce the role of cyclotrons in the production of unconventional radionuclides for PET imaging while using 45 Ti as an example to explore the potential biomedical applications of those radionuclides in PET imaging.

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Section: Cyclotrons and The Production Of Unconventional Radionuclidesmentioning

confidence: 99%