Production of Scaffolds Using Melt Electrospinning Writing and Cell Seeding

Bolle, Eleonore C.L.; Nicdao, Deanna; Dalton, Paul D.; Dargaville, Tim R.

doi:10.1007/978-1-0716-0611-7_9

Cited by 6 publications

(2 citation statements)

References 26 publications

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“…Moreover, the scaffolds with a large surface area, high porosity, and controlled deposition of the fibers could be fabricated using this technique. This was demonstrated by fabricating cellscaffold constructs using poly(ε-caprolactone) using MEW for seeding primary human-derived dermal fibroblasts [40].…”

Section: Temperature-assisted (Cryogenic/melt) Electrospinningmentioning

confidence: 99%

An overview on electrospinning and its advancement toward hard and soft tissue engineering applications

Muthukrishnan

2022

Colloid Polym Sci

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One of the emerging technologies of the recent times harboring nanotechnology to fabricate nanofibers for various biomedical and environmental applications are electrospinning (nanofiber technology). Their relative ease in use, simplicity, functionality and diversity has surpassed the pitfalls encountered with the conventional method of generating fibers. This review aims to provide an overview of electrospinning, principle, methods, feed materials, and applications toward tissue engineering. To begin with, evolution of electrospinning and its typical apparatus have been briefed. Simultaneously, discussion on the production of nanofibers with diversified feed materials such as polymers, small molecules, colloids, and nanoparticles and its transformation into a powerful technology has been dealt with. Further, highlights on the application of nanofibers in tissue engineering and the commercialized products developed using nanofiber technology have been summed up. With this rapidly emerging technology, there would be a great demand pertaining to scalability and environmental challenge toward tissue engineering applications.

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Section: Temperature-assisted (Cryogenic/melt) Electrospinningmentioning

confidence: 99%

An overview on electrospinning and its advancement toward hard and soft tissue engineering applications

Muthukrishnan

2022

Colloid Polym Sci

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“…However, the potential toxicity of sacrificial material is the most important limiting factor for this technology. Finally, rapidly evolving melt electrospinning is becoming another prospective method for precise high-resolution fabrication of mini-scaffolds for tissue engineering and regenerative medicine [ 13 , 14 , 15 ].…”

Section: Creation and Characterization Of Functionalized Mini-scaffoldsmentioning

confidence: 99%

Design, Fabrication, and Application of Mini-Scaffolds for Cell Components in Tissue Engineering

et al. 2022

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The concept of “lockyballs” or interlockable mini-scaffolds fabricated by two-photon polymerization from biodegradable polymers for the encagement of tissue spheroids and their delivery into the desired location in the human body has been recently introduced. In order to improve control of delivery, positioning, and assembly of mini-scaffolds with tissue spheroids inside, they must be functionalized. This review describes the design, fabrication, and functionalization of mini-scaffolds as well as perspectives on their application in tissue engineering for precisely controlled cell and mini-tissue delivery and patterning. The development of functionalized mini-scaffolds advances the original concept of “lockyballs” and opens exciting new prospectives for mini-scaffolds’ applications in tissue engineering and regenerative medicine and their eventual clinical translation.

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Melt Electrowriting of Amphiphilic Physically Crosslinked Segmented Copolymers

Bakırcı

Frank

Gumbel

et al. 2021

Macro Chemistry & Physics

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Various (AB)n and (ABAC)n segmented copolymers with hydrophilic and hydrophobic segments are processed via melt electrowriting (MEW). Two different (AB)n segmented copolymers composed of bisurea segments and hydrophobic poly(dimethyl siloxane) (PDMS) or hydrophilic poly(propylene oxide)‐poly(ethylene oxide)‐poly(propylene oxide) (PPO‐PEG‐PPO) segments, while the amphiphilic (ABAC)n segmented copolymers consist of bisurea segments in the combination of hydrophobic PDMS segments and hydrophilic PPO‐PEG‐PPO segments with different ratios, are explored. All copolymer compositions are processed using the same conditions, including nozzle temperature, applied voltage, and collector distance, while changes in applied pressure and collector speed altered the fiber diameter in the range of 7 and 60 µm. All copolymers showed excellent processability with MEW, well‐controlled fiber stacking, and inter‐layer bonding. Notably, the surfaces of all four copolymer fibers are very smooth when visualized using scanning electron microscopy. However, the fibers show different roughness demonstrated with atomic force microscopy. The non‐cytotoxic copolymers increased L929 fibroblast attachment with increasing PDMS content while the different copolymer compositions result in a spectrum of physical properties.

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Production of Scaffolds Using Melt Electrospinning Writing and Cell Seeding

Cited by 6 publications

References 26 publications

An overview on electrospinning and its advancement toward hard and soft tissue engineering applications

An overview on electrospinning and its advancement toward hard and soft tissue engineering applications

Design, Fabrication, and Application of Mini-Scaffolds for Cell Components in Tissue Engineering

Melt Electrowriting of Amphiphilic Physically Crosslinked Segmented Copolymers

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