Production of <scp>l</scp>-allose and <scp>d</scp>-talose from <scp>l</scp>-psicose and <scp>d</scp>-tagatose by <scp>l</scp>-ribose isomerase

Terami, Yuji; Uechi, Keiko; Nomura, Saki; Okamoto, Naoki; Morimoto, Kenji; Takata, Goro

doi:10.1080/09168451.2015.1038215

Cited by 12 publications

(7 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…PrM Pre-marathon, PM Post-marathon, D1 24 h post-marathon, D2 48 h post-marathon. Significant p-and d-values (*).www.nature.com/scientificreports/ of the detected metabolite markers(Table 1)31,33 could also be ascribed to the restoration of GM homeostasis and a reduction in host substrate availability/dietary ingestion.…”

mentioning

confidence: 98%

The unaided recovery of marathon-induced serum metabolome alterations

Stander

Luies

Mienie

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Endurance athlete performance is greatly dependent on sufficient post-race system recovery, as endurance races have substantial physiological, immunological and metabolic effects on these athletes. To date, the effects of numerous recovery modalities have been investigated, however, very limited literature exists pertaining to metabolic recovery of athletes after endurance races without the utilisation of recovery modalities. As such, this investigation is aimed at identifying the metabolic recovery trend of athletes within 48 h after a marathon. Serum samples of 16 athletes collected 24 h before, immediately after, as well as 24 h and 48 h post-marathon were analysed using an untargeted two-dimensional gas chromatography time-of-flight mass spectrometry metabolomics approach. The metabolic profiles of these comparative time-points indicated a metabolic shift from the overall post-marathon perturbed state back to the pre-marathon metabolic state during the recovery period. Statistical analyses of the data identified 61 significantly altered metabolites including amino acids, fatty acids, tricarboxylic acid cycle, carbohydrates and associated intermediates. these intermediates recovered to pre-marathon related concentrations within 24 h post-marathon, except for xylose which only recovered within 48 h. Furthermore, fluctuations in cholesterol and pyrimidine intermediates indicated the activation of alternative recovery mechanisms. Metabolic recovery of the athletes was attained within 48 h post-marathon, most likely due to reduced need for fuel substrate catabolism. this may result in the activation of glycogenesis, uridine-dependent nucleotide synthesis, protein synthesis, and the inactivation of cellular autophagy. These results may be beneficial in identifying more efficient, targeted recovery approaches to improve athletic performance. Endurance races (> 5 km) have become increasingly popular over the last decade and primarily include halfmarathons (21.1 km), marathons (42.2 km), and ultra-marathons (> 42.2 km) 1. Participation in these events requires extensive preparation including physical and mental conditioning as well as meticulously planned dietary strategies. According to Barnett 2 , optimal athletic performance is only achieved when these principles are accompanied by sufficient system recovery following any endurance activity. "Recovery" comprehensively refers to the process in which an altered biological system, such as the metabolome, reverts to its corresponding pre-perturbed state 3. In endurance athletes, metabolic recovery is thought to proceed in a biphasic manner with the initial phase mainly consisting of rapid oxygen, ATP and phosphocreatine replenishment, whereas the second phase entails the slow restoration of innate metabolism adaptations 2,3. A popular research approach for identifying and mapping such metabolic adaptations, quantitatively and qualitatively, is collectively referred to as "metabolomics". Considering that the metabolome provides a direct depiction of the physiological st...

show abstract

mentioning

confidence: 98%

The unaided recovery of marathon-induced serum metabolome alterations

Stander

Luies

Mienie

et al. 2020

Sci Rep

View full text Add to dashboard Cite

show abstract

“…Unfortunately, none of the reported isomerases shows a high activity toward L-hexoses. Still, some aldose isomerases have been used for Laldohexose production, including L-rhamnose isomerase (EC 5.3.1.14) (Bhuiyan et al 1997;Leang et al 2004a;Takata et al 2011), L-ribose isomerase (EC 5.3.1.B3) (Terami et al 2015), and D-arabinose isomerase (EC 5.3.1.3) (Leang et al 2003). Some aldose phosphate isomerases have also shown potential for the application of L-aldohexose production, including D-ribose-5-phosphate isomerase (EC 5.3.1.6) (Park et al 2010), D-glucose-6-phosphate isomerase (EC 5.3.1.9) ), D-mannose-6-phosphate isomerase (EC 5.3.1.8) , and D-galactose-6-phosphate isomerase (EC 5.3.1.26) (Park et al 2007).…”

Section: C-3 Epimerization Between L-ketohexosesmentioning

confidence: 99%

“…The enzyme was also used for L-allose production from L-psicose via immobilization on DIAION HPA25L beads. The immobilized enzyme produced 33 g L −1 of L-allose from 100 g L −1 of L-psicose after a 1-day reaction (Terami et al 2015).…”

Section: Isomerization Of L-psicosementioning

confidence: 99%

Advances in the enzymatic production of l-hexoses

Chen

Zhang

et al. 2016

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Rare sugars have recently drawn attention because of their potential applications and huge market demands in the food and pharmaceutical industries. All L-hexoses are considered rare sugars, as they rarely occur in nature and are thus very expensive. L-Hexoses are important components of biologically relevant compounds as well as being used as precursors for certain pharmaceutical drugs and thus play an important role in the pharmaceutical industry. Many general strategies have been established for the synthesis of L-hexoses; however, the only one used in the biotechnology industry is the Izumoring strategy. In hexose Izumoring, four entrances link the D- to L-enantiomers, ketose 3-epimerases catalyze the C-3 epimerization of L-ketohexoses, and aldose isomerases catalyze the specific bioconversion of L-ketohexoses and the corresponding L-aldohexoses. In this article, recent studies on the enzymatic production of various L-hexoses are reviewed based on the Izumoring strategy.

show abstract

“…Particularly, L-psicose has been used as starting material for the production of L-fructose, 8a and other L-sugars. 45 Derivatives of altritol have been used to prepare altritol nucleic acids (ANA), which show good potential for improving the therapeutic use of RNA interference, providing protection against nuclease cleavage. 46 Several alditols from rare sugars also display laxative effects.…”

Section: Figure 1 Aldehyde Acceptor For the Aldol Reactionmentioning

confidence: 99%