Production of Shigella dysenteriae Type 1-Like Cytotoxin by Escherichia coli

O'Brien, A D; LaVeck, Gerald D.; Thompson, Michael R.; Formal, Samuel B.

doi:10.1093/infdis/146.6.763

Cited by 417 publications

(282 citation statements)

References 31 publications

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“…The involvement of such factors in the pathogenesis of diarrhoea has been suggested (Scotland et al 1980;Caprioli et al 1983;O'Brien & Laveck, 1983), but it still remains unproven. Our data seem to confirm the role of cytotoxins and hemolysin as virulence factors.…”

Section: Resultsmentioning

confidence: 99%

Toxin production and haemagglutination in strains ofEscherichia colifrom diarrhoea in Brescia, Italy

Bisicchia

Ciammarughi

Caprioli

et al. 1985

J. Hyg.

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SUMMARYTwo hundred and ninety-nine different strains of Escherichia coli, isolated from 172 patients with diarrhoea and 113 healthy subjects, were examined for enterotoxin, cytotoxin and haemolysin (Hly) production and for mannose-resistant haemagglutination (MRHA) and invasive properties. Three strains proved enterotoxigenic, none enteroinvasive; cytotoxin and Hly production was shown in 25 strains from patients and in 3 from controls. Ten strains produced the cytotoxic necrotizing factor (CNF), 6 released other factors which kill cell cultures. Hly production was shown in 21 strains, 9 of which were also positive for CNF. MRHA was detected in 26 % of strains from diarrhoea compared with 140 of strains from healthy people. A strong association between toxin production and MRHA was demonstrated. Serotyping results showed that the strains exhibiting virulence traits mostly belonged to serogroups commonly involved in extra-intestinal infections. The possible role of strains of E. coli showing one or more virulence factors as opportunistic pathogens in diarrhoeal diseases is discussed.

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Section: Resultsmentioning

confidence: 99%

Toxin production and haemagglutination in strains ofEscherichia colifrom diarrhoea in Brescia, Italy

Bisicchia

Ciammarughi

Caprioli

et al. 1985

J. Hyg.

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“…Many subsequent studies showed that the VT described by Konowa1chuk et al (1977) was virtually identical to the Shiga toxin of Shigella dysenteriae type I (O'Brien et al 1982) first described by Conradi (1903). Subsequently, an antigenically distinct group of toxins with similar biological activity was described by Strockbine et al (1986), who also showed that these toxins are encoded on bacteriophages.…”

Section: Historical Perspectivementioning

confidence: 93%

Role of non-O157 VTEC

Bettelheim

2000

Journal of Applied Microbiology

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SUMMARY Non‐O157 VTEC are typical Escherichia coli that differ only in their ability to produce verocytotoxins (VT). The transmission of VTEC is discussed in relation to the transmission of commensal E. coli. The emergence over the last few decades of a great variety of VTEC serotypes from healthy and diseased humans and animals is described. Particular attention is given to the distribution of the more important serogroups pathogenic for humans that have been described from around the world, particularly serogroups O26, O111, O128 and O103. The possible role of ruminants as reservoirs is discussed. The problems of laboratory diagnosis of non‐O157 VTEC are considered and various laboratory methods are assessed. Evidence is presented that the particular E. coli serotypes now known to be VTEC were present in humans and animals many years ago, but have acquired the ability to produce VT and probably other virulence factors. Finally, predictions are made of the possible increase in problems associated with these emerging pathogens.

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“…VT+ strains included 20 strains belonging to serotype 0 26 H 11, 2 of serotype 0 26 Hand 2 of 0 128 H2. O'Brien et al (1982) demonstrated the production of VT by EPEC strains of other serogroups when grown in an iron-depleted medium. The significance of these findings has yet to be established.…”

Section: Pathogenesismentioning

confidence: 93%

Escherichia colidiarrhoea

Gross

Rowe

1985

J. Hyg.

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Ever since Escherich (1885) first isolated the organism now known asEscherichia colifrom the stools of infants, medical microbiologists have been faced with the problem of distinguishing between those strains capable of causing diarrhoea and those that are harmless gut commensals. Epidemiological investigations were greatly facilitated by the description by Kauffmann (1947) of a serotyping scheme forE. coli, and Taylor (1961) later reported that 17 0 serogroups ofE. colihad been implicated as possible causes of epidemic infantile enteritis. These infantile enteropathogenicE. coli(EPEC), having been discovered by epidemiological studies using serotyping, belonged by definition to a restricted range of serogroups. More recently it was shown that otherE. colistrains may produce enterotoxins, and these enterotoxigenicE. coli(ETEC) usually belong to particular serogroups which are different from those associated with EPEC.E. colistrains belonging to a third range of serogroups may cause an illness resembling shigella dysentery, and these may be regarded as entero-invasiveE. coli(EIEC).E. colistrains that cause diarrhoea may therefore be considered as three groups, as follows.

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Production of Shigella dysenteriae Type 1-Like Cytotoxin by Escherichia coli

Cited by 417 publications

References 31 publications

Toxin production and haemagglutination in strains ofEscherichia colifrom diarrhoea in Brescia, Italy

Toxin production and haemagglutination in strains ofEscherichia colifrom diarrhoea in Brescia, Italy

Role of non-O157 VTEC

Escherichia colidiarrhoea

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