Production of Silkworms with Conjugated Linoleic Acid (CLA) Incorporated into Their Lipids by Dietary CLA

Park, Chung G.; Park, Gu B.; Kim, Young S; Kim, Seck J.; Min, David B.; Ha, Yeong Lae

doi:10.1021/jf052579w

Cited by 5 publications

(5 citation statements)

References 38 publications

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“…Egg embryogenesis was not impacted by maternal dietary CLA, which was previously reported in laying hens [21, 22]. Park et al, 2006 observed that silkworms fed on a 10% CLA diet had significantly reduced body weight and food intake compared to control silkworms over the 4 th instar stage [23]. In the common house fly, researchers concluded intake up to 10% CLA had no adverse fitness effects on any stage of the insects evaluated [24].…”

Section: Introductionmentioning

confidence: 70%

Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata

et al. 2019

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The Colorado Potato Beetle, Leptinotarsa decemlineata, is a major agricultural pest of solanaceous crops in the United States. Historically, a multitude of insecticides have been used to control problematic populations. Due to increasing resistance to insecticides, novel compounds and methodologies are warranted for the control of beetle populations. Mixed-isomer conjugated linoleic acid has been studied in-depth for its beneficial properties to mammalian systems. At the same time, studies have demonstrated that conjugated linoleic acid can manipulate fatty acid composition in non-mammalian systems, resulting in embryo mortality. Consequently, experiments were conducted to assess the effects of foliar-applied conjugated linoleic acid on larval growth, embryogenesis, and feeding preference in Colorado potato beetle. Both maternal and deterrent effects of dietary conjugated linoleic acid were assessed. Conjugated linoleic acid demonstrated desirable insecticidal properties, including increased larval mortality, slowed larval development, antifeedant effects, and decreased egg viability after maternal ingestion.

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Section: Introductionmentioning

confidence: 70%

Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata

et al. 2019

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“…Furthermore, the C/EBP-binding sites predicted in the 5′-flanking region of AccFABP may be involved in the regulation of FABP genes and intermediary metabolism (Bernlohr et al 1997). Recent studies have shown that CLA accumulated in the tissues of houseflies and silkworms after breeding, affecting lipid metabolism (Park et al 2000, 2006). The levels and ratio of DHA and AA could influence development across animal species, and dietary deficiency could cause reproductive failure and reduced growth (Davis-Bruno et al 2011).…”

Section: Discussionmentioning

confidence: 99%

“…In addition, FAs play a role in the transcription of genes that encode proteins involved in lipid metabolism (Duplus et al 2000). Conjugated linoleic acid (CLA), which is a type of FA, has unique effects on lipid metabolism, and also provides several health benefits for humans and insects (Park et al 2006). Docosahexaenoic acid (DHA) and arachidonic acid (AA), which are major FAs of the retina, affect gene expression by regulating the activity and concentration of transcription factors within the nucleus (Saino-Saito et al 2009).…”

Section: Introductionmentioning

confidence: 99%

Identification and Expression Analysis of a Putative Fatty Acidbinding Protein Gene in the Asian Honeybee,Apis cerana cerana

Kang

Liu

et al. 2013

Journal of Insect Science

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Fatty acid-binding proteins (FABPs) play pivotal roles in cellular signaling, gene transcription, and lipid metabolism in vertebrates and invertebrates. In this study, a putative FABP gene, referred to as AccFABP, was isolated from the Asian honeybee, Apis cerana cerana Fabricius (Hymenoptera: Apidae). The full-length cDNA consisted of 725 bp, and encoded a protein of 204 amino acids. Homology and phylogenetic analysis indicated that AccFABP was a member of the FABP multifamily. The genomic structure of this gene, which was common among FABP multifamily members, spanned 1,900 bp, and included four exons and three introns. Gene expression analysis revealed that AccFABP was highly expressed in the dark-pigmented phase of pupal development, with peak expression observed in the fat bodies of the dark-pigmented phase pupae. The AccFABP transcripts in the fat body were upregulated by exposure to dietary fatty acids such as conjugated linoleic acid, docosahexaenoic acid, and arachidonic acid. Transcription factor binding sites for Caudal-Related Homeobox and functional CCAAT/enhancer binding site, which were respectively associated with tissue expression and lipid metabolism, were detected in the 5′ promoter sequence. The evidence provided in the present study suggests that AccFABP may regulate insect growth and development, and lipid metabolism.

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“…The administration of DNJ extracted from mulberry suppresses an increase in postprandial blood glucose in humans (Tsuduki et al ., 2009) and the lipid-lowering effects of mulberry water extracts (MME) for 12 weeks on hamsters showed hypolipidemic effects of high fat cholesterol diets with 1 and 2% (MME) (Liu et al ., 2009) . Conjugated linoleic acid (CLA) provides several health benefits for humans as an anticarcinogenic or antiatherosclerogenic agent (Park et al ., 2006) .…”

Section: Introductionmentioning

confidence: 99%

“…Silkworms with conjugated linoleic acid (CLA) incorporated into lipids were produced to enhance the quality of silkworms having a synergistic effect with CLA functions by dietary synthetic CLA (Park et al ., 2006) .…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid Composition of Adipose Tissues in Obese Mice and SD Rats Fed with Isaria sinclairii Powder

Ahn

Seo

et al. 2010

Toxicological Research

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Isaria sinclairii (Cicada Dongchunghacho) was studied as a potential crude natural food in powdered form. The role of tissue fatty acids in relation to the anti-obesity effects of I. sinclairii (IS) was examined by feeding the powder to SD rats ad libitum at 0, 1.25, 2.5, 5 and 10% (calculated about 8 g/kg) of the feed for a period of 3 months and 6 months. The fatty acid composition profile as indicated GC-MS, showed significantly slight dose-dependent increases in the levels of unsaturated fatty acids, particularly, arachidonic acid (C20: 4n6) , oleic acid, linoleic acid, eicosadienoic acid, eicosapentaenoic acid (EPA) (C20: 5) concentration in the the ad libitum IS-fed groups compared to the control group in SD abdominal fat over 6 month period. Over viewing of the SD and Ob mice treated Isaria sinclairii powder; there were increases in the single (mono) unsaturated fatty acids ratio but decreases in polyunsaturated fatty acid. In IS-fed groups in proportion to the treatment period, this Dongchunghacho also induced an increase in the level of same result of unsaturated fatty acid in C57BL/6 obese (ob/ob) mice over a 6-month period treatment compared to those given 10% dry mulberry leaf powder (ML) or silkworm powder mixed with the standard diet.

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Production of Silkworms with Conjugated Linoleic Acid (CLA) Incorporated into Their Lipids by Dietary CLA

Cited by 5 publications

References 38 publications

Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata

Conjugated linoleic acid as a novel insecticide targeting the agricultural pest Leptinotarsa decemlineata

Identification and Expression Analysis of a Putative Fatty Acidbinding Protein Gene in the Asian Honeybee,Apis cerana cerana

Fatty Acid Composition of Adipose Tissues in Obese Mice and SD Rats Fed with Isaria sinclairii Powder

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