Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

Yu, Wangyang; Xia, Fei; Jin, Heyang; Lin, Changchun; Zhao, Yaping; Si-yuan, Jiang; Lin, He

doi:10.1016/s1004-9541(09)60023-9

Cited by 12 publications

(2 citation statements)

References 11 publications

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“…As consequent, the liquid solvent power decreases significantly and causes sharp increase in supersaturation level of the liquid mixture, which results in formation of microparticles [1,13]. There have been several research studies that used ASES method to produce fine particles [27][28][29].…”

Section: Aerosol Solvent Extraction System (Ases)mentioning

confidence: 99%

Formation of fine particles using supercritical fluid (SCF) process: Short review

Chafidz

Jauhary

Kaavessina

et al. 2018

CST

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This paper will discuss about the utilization of supercritical fluid (SCF) process to produce fine particles. Supercritical fluids (SCFs) process can be considered as an emerging "clean" technology for the production of small-size or fine particles (e.g. micron-size). Microsphere is a material in micron scale which has been widely used as adsorbent, catalyst support, and drug delivery system. For advanced application, those materials are formulated in the form of porous microspheres. There are several methods that can be used using SCFs. Those method are, Rapid Expansion of Supercritical Solution (RESS), Gas Anti-Solvent/Supercritical Anti-Solvent (GAS/ SAS), Aerosol Solvent Extraction System (ASES), dan Solution Enhanced Dispersion by Supercritical Fluids (SEDS) and Particle from Gas-Saturated Solutions/Suspensions (PGSS). Considering the morphology of material which will be used to prepare microsphere, each of methods above has specific advantages and disadvantages toward the material. Based on the literatures, the ASES method is more likely to produce porous microparticles (microspheres). In the ASES method, porous microsphere formation is the result of interactions between: degrees of supersaturation, nucleation velocity and crystal growth.

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Section: Aerosol Solvent Extraction System (Ases)mentioning

confidence: 99%

Formation of fine particles using supercritical fluid (SCF) process: Short review

Chafidz

Jauhary

Kaavessina

et al. 2018

CST

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“…No meta‐analyses have yet to access the cholesterol lowering efficacy between functional foods made with different free phytosterol incorporation methods, likely due to the lower number of published trials using free phytosterols and the proprietary and often vague descriptions of the incorporation methods. Some of the incorporation methods for free phytosterols include emulsion with lecithin 44, supersaturation using crystallization inhibitors 42, sub‐particularization using aerosol solvent extraction 45, and microemulsion by solvent displacement 41, 43 or rapid expansion of supercritical solution into aqueous solution 46. Each of these methods have been developed to incorporate free phytosterols into functional foods and center around reducing crystallization and/or particle size while maximizing the free phytosterols solubility.…”

Section: Cholesterol Lowering Action In Phytosterol Trials Using Capsmentioning

confidence: 99%

Phytosterols in human nutrition: Type, formulation, delivery, and physiological function

MacKay

Jones

2011

Euro J Lipid Sci & Tech

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Phytosterols are a family of compounds similar to cholesterol which have been shown to lower cholesterol levels when supplemented in the diet. A daily dose of 2-3 g of phytosterols has been shown to reduce LDL-cholesterol levels by 5-15%. Phytosterol supplementation can be undertaken using phytosterol enriched functional foods or nutraceutical preparations. The type of phytosterol supplemented, such as plant sterol or saturated plant stanol appear to be equally effective in lowering cholesterol levels. Phytosterols, whether in esterified or free form have both been shown to lower cholesterol levels, with esterified phytosterol formulations having a greater number of clinical trials demonstrating efficacy. The functional food or nutraceutical matrix which is used to deliver supplemental phytosterols can significantly affect cholesterol lowering efficacy. Effective cholesterol lowering by phytosterols depends on delivery of phytosterols to the intestine in a form which can compete with cholesterol for absorption. New phytosterol functional food and nutraceuticals products should always be tested to demonstrate adequate delivery of phytosterol dose and effective total and LDL-cholesterol lowering. Phytosterol products which do not effectively lower cholesterol will negatively impact the perception and use of phytosterols, and must not be allowed on the marketplace.

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Progress in Supercritical Fluid Technology for Fats and Oils Processing

Temelli

Güçlü‐Üstündağ

Couto

2020

Bailey's Industrial Oil and Fat Products

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Supercritical CO 2 (SC‐CO 2 ) processing of fats and oils has been widely investigated since SC‐CO 2 offers an environmentally friendly alternative with added advantages such as moderate operating conditions and solvent‐free extracts and residues. From a processing perspective, a unique advantage of SC‐CO 2 processing lies in its versatility, which results from the ability to modify solvent properties by changing operating conditions (temperature and pressure) or by the addition of cosolvents. A good understanding of the fundamentals of solubility behavior of lipid components in SC‐CO 2 as affected by operating conditions and solute properties is required to realize its full potential in fats and oils processing. The operational flexibility offered by supercritical fluid technology enables the processor to fine‐tune solvent properties and to develop novel processes by the integration of unit operations of extraction, fractionation, reaction, and particle formation to meet the process objectives. These unit operations have been effectively utilized for the extraction and refining of oils, concentration of bioactive components from oils or oil by‐products, modification of the physical properties of fats and oils, production of oleochemicals and design of delivery systems for numerous applications.

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Production of Submicroparticles of β-Sitosterol Using an Aerosol Solvent Extraction System

Cited by 12 publications

References 11 publications

Formation of fine particles using supercritical fluid (SCF) process: Short review

Formation of fine particles using supercritical fluid (SCF) process: Short review

Phytosterols in human nutrition: Type, formulation, delivery, and physiological function

Progress in Supercritical Fluid Technology for Fats and Oils Processing

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