Production of Tetanus Antitoxin by Patients with Hepatic Cirrhosis

Havens, W. Paul; Myerson, Ralph M.; Klatchko, Jean.

doi:10.1056/nejm195710032571402

Cited by 34 publications

(10 citation statements)

References 2 publications

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“…The present observa tions do not support the theory of excessive antigen stimulation, and may therefore sup port the theory of an increased humoral im munity due to a hyperactive immune state. Thus, Havens et al [33] reported an aug mented reactivity to immunization in pa tients with cirrhosis and recent studies have demonstrated increased rates of immuno globulin synthesis by peripheral lymphoid cells of patients with alcoholic cirrhosis [34,35]. Only for completeness, a combination of increased antigen load and increased hu moral reactivity should also be kept in mind.…”

Section: Discussionmentioning

confidence: 99%

Autoantibodies and Immunoglobulins in Patients with Alcoholic Cirrhosis

Gluud¹,

Tage-Jensen²,

Rubinstein³

et al. 1984

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In order to evaluate the possible relation between hepatic function and hemodynamics and the increased humoral immune response of cirrhotic patients, titres of antinuclear antibodies (ANA) and smooth muscle antibodies (SMA) and concentrations of immunoglobulin (Ig) G, A and M were determined in 74 consecutive patients with alcoholic liver cirrhosis. Patients showed significantly (p < 0.05) increased prevalences of ANA and SMA and concentrations of Ig G, A and M when compared to controls. No significant correlations were found between titres of ANA or SMA and hepatic scan score, galactose elimination capacity, indo-cyanine green clearance, hepatic blood flow and wedged-to-free hepatic vein pressure. Hepatic scan score correlated directly (p = 0.38, p < 0.05) to IgA concentrations; wedged-to-free hepatic vein pressure correlated directly to IgG concentrations (p = 0.35, p < 0.05) and to IgM concentrations (p = 0.42, p < 0.01). No other significant correlations were found between Ig concentrations and variables of hepatic function or hemodynamics.

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Section: Discussionmentioning

confidence: 99%

Autoantibodies and Immunoglobulins in Patients with Alcoholic Cirrhosis

Gluud¹,

Tage-Jensen²,

Rubinstein³

et al. 1984

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“…It remains to be determined whether these findings are to be attributed to an enhanced capacity for antibody production in this disease, as suggested by Havens et al [4], or to the failure of the hepatic barrier to filter off antigenic stimuli arising from intestinal microbial flora [1,2,11]. In this latter hypothesis, it would be necessary to admit common determinants between T and microbial antigens, giving rise to an efficient stimulus for anti-T production.…”

mentioning

confidence: 97%

Anti-T Agglutinin in Cirrhosis of the Liver

Boccardi¹,

Attiná²,

Bigliocchi³

et al. 1974

Vox Sanguinis

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“…The influence of liver function disturbances on antibody formation has been studied by different authors (1,3,4,5,6,9,10); but investigations on the effect of antibody formation on liver function do not exist.…”

Section: Medizinische Poliklinik Der Universität Marburg An Der Lahnmentioning

confidence: 99%