Production of the Generalized Shwartzman Reaction in Pregnant Rats by Intravenous Infusion of Thrombin

Margaretten, William; Zunker, Heinz O.; McKay, Donald G.

doi:10.1097/00006254-196412000-00003

Cited by 23 publications

(32 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Furtherm ore shortening of the plastic clotting tim e in the course of experim ental acute pancreatitis has been found [7]. The inhibition of euglobulin fibrinolysis observed in our experim ent is quite similar to th a t of the Shwartzm an reaction [18].…”

Section: Discussionsupporting

confidence: 81%

See 1 more Smart Citation

Heparin and Protease Inhibitors in the Prevention of Experimental Acute Pancreatic Necrosis in Dogs

et al. 1969

View full text Add to dashboard Cite

The protective action of protease inhibitors (Trasylol, IP-315) the synthetic antifibrinolytic agent (EACA) and heparin in the prevention of acute pancreatic necrosis was evaluated on the basis of serum amylase, histological examination and survival of dogs. Heparin was found to be the most efficient agentin protecting dogs from pancreatic necrosis, the other protease inhibitors were much less effective.In dogs pretreated with heparin no elevation of fibrinogen level and no inhibition of fibrinolysis were observed. These changes were markedly expressed in control dogs with pancreatic necrosis and those receiving profease inhibitors. The total proteolytic activity of pancreas homogenates was investigated. A significant difference in the heparin-treated dogs in comparison with the controls was observed. Similar differences were obtained on testing acid phosphatase in both groups. Successful prevention of acute pancreatitis by heparin can also be explained as being due to the anti-clotting properties of this drug as well as to its action on the level of the pancreatic cell. It is also possible that heparin has a stabilizing effect on lysosomes, known to be the main source of hydrolases.

show abstract

Section: Discussionsupporting

confidence: 81%

“…It lias been found th a t heparin in adequate doses prevents the development of the Shwartzman reaction [18]. It is assumed th at the beneficial mechanism of heparin action is based on the inhibition of intravascular coagulation.…”

Section: Discussionmentioning

confidence: 99%

Heparin and Protease Inhibitors in the Prevention of Experimental Acute Pancreatic Necrosis in Dogs

et al. 1969

View full text Add to dashboard Cite

show abstract

“…Secondly, pregnancy is known to predispose to the Sanarelli-Shwartzman reaction (32). Margaretten and colleagues (33) observed that prolonged infusion of thrombin resulted in renal cortical necrosis in a large proportion of pregnant rats, whereas there were no lesions in nonpregnant animals. Thrombin infusion also caused renal cortical necrosis in nonpregnant 40r animals that had received an infusion of epsilon-amino caproic acid, an inhibitor of plasminogen activation.…”

Section: Discussionmentioning

confidence: 99%

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

Colucci¹,

Paramo²,

Collen³

1985

J. Clin. Invest.

414

159

View full text Add to dashboard Cite

Endotoxin producing bacteria cause disseminated intravascular coagulation (DIC); however, the mechanism of endotoxin action in man is still unclear. Impairment of the fibrinolytic system has been suggested as a contributing mechanism.A single injection of Escherichia coli lipopojysaccharide in rabbits resulted in a marked and prolonged increase of the levels of a fast-acting inhibitor of plasminogen activator (PAinhibitor) in plasma (from 3.9±0.7 to 41±13.2 U/ml after 3 h). Gel filtration studies indicated that inhibition of human tissue-type plasminogen activator (t-PA) by rabbit plasma is accompanied by a change in the elution profile of the activator compatible with the formation of an enzyme-inhibitor complex with an apparent molecular weight of 100,000. Injection of human t-PA (1,500 IU/kg body wt) in endotoxin treated animals resulted in very fast inhibition of t-PA and formation of a similar complex.The half-life of circulating PA-inhibitor activity in rabbits was about 7 min as estimated by donor receiver plasma transfusion experiments.Stimulation of cultured human endothelial cells with endotoxin resulted in enhanced rate of accumulation of PAinhibitor activity in the culture medium (two-to sevenfold increase). In five patients with septicemia, markedly increased levels of PA-inhibitor (14.3±15.5 U/ml) as compared with control subjects (13±0.7 U/ml) were observed in plasma.A very strong correlation (r = 0.98) was found between inhibition of t-PA and of urokinase in all conditions, suggesting that this fast-acting inhibitor reacts with both plasminogen activators.These data suggest that the appearance of this fast-acting PA-inhibitor is very sensitive to endotoxin stimulation. The marked increase in the level of PA-inhibitor in blood may contribute to the pathogenesis of DIC in septicemia.

show abstract

“…A difference in clinical events, however, between the two sequential nephrostomies was the usage of thrombin irrigation into the kidney. Because Margaretten et al [9] reported the induction of cortical necrosis in pregnant rat by intravenous infusion of thrombin, we could not exclude the possibility that part of thrombin might have entered into the systemic circulation and activated the clotting system with resultant cortical nec rosis.…”

Section: Discussionmentioning

confidence: 98%

Asynchronous Cortical Necrosis after Bilateral Nephrostomy

Sakemi¹,

Masaki²,

Yamaguchi³

et al. 1989

Nephron

View full text Add to dashboard Cite

Production of the Generalized Shwartzman Reaction in Pregnant Rats by Intravenous Infusion of Thrombin

Cited by 23 publications

References 0 publications

Heparin and Protease Inhibitors in the Prevention of Experimental Acute Pancreatic Necrosis in Dogs

Heparin and Protease Inhibitors in the Prevention of Experimental Acute Pancreatic Necrosis in Dogs

Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation.

Asynchronous Cortical Necrosis after Bilateral Nephrostomy

Contact Info

Product

Resources

About