Production of Tumours in Mice by Deoxycholic Acid

Association Between Screen-Detected Gallstone Disease and Cancer in a Cohort Study

“…43,44 The predilection of the right-side colon has been suggested through a greater proximal colonic absorption of fecal secondary bile acids, 15 which have been considered carcinogenic for a long time. 45,46 An altered activity of colonic microbiota after cholecystectomy, including an increased bacterial degradation of bile acids into fecal secondary bile acids has also been suggested. 44,47 Recently, cholecystectomy has also been shown to alter bacterial composition of the colon with a significant increase in the phylum Bacteroidetes species, which also have been associated with colorectal cancer.…”

Effect of Cholic Acid on Tumor in the Egyptian Toad

“…This increase in fecal dcoxycholic acid was due to bacterial 7 a-dchydroxylation of cho lic acid in the colonic contents [4], It is worth mention ing that load bile contains bufodeoxycholic acid [8]. A number of investigators [5,9,11] have become interested in the potential carcinogenic activity of cer tain bile acids because they may be chemically con verted into 3-mcthylcholanthrene; several bile acids such as deoxycholic acid induced sarcomas at the site of injection in experimental animals.…”

Further Tests for Tumour-Initiating Activity: N,N-DI-(2-Chloroethyl)-P-Aminophenylbutyric Acid (CB1348) as an Initiator of Skin Tumour Formation in the Mouse

“…Deoxycholic acid.-Occasional epitheliomata have been seen in mice painted with deoxycholic acid repeatedly over long periods (Bachmann et al, 1937;Badger et al, 1940;Cook, Kennaway and Kennaway, 1940), and subcutaneous injection into mice has given rise to sarcomata after a prolonged period (Badger et al, 1940). Klein (1952) found that deoxycholic acid applied to the skin gave rise to no tumours either when used alone or in conjunction with croton oil.…”