Production of vitamin B1 microparticles by a spray drying process using different biopolymers as wall materials

Abstract

The aim of this work was to microencapsulate vitamin B1 by spray‐drying using different encapsulating agents (arabic gum, carrageenan, chitosan, maltodextrin, modified chitosan, modified starch, pectin, sodium alginate, and xanthan) and to characterize the microcapsules and study their release. Microcapsules with a 0.25% (w/w) content of vitamin B1 were produced. The product yield results ranged from 17%‐52% and the encapsulation efficiency from 66%‐100%. Three categories of morphology, regular spherical shape, irregular spherical shape with rough surface, and irregular shape, were identified. Their sizes, determined by laser granulometry, ranged from 0.11‐1.32 μm, in terms of number distribution, and from 3.76‐34.43 μm, in volume distribution. Controlled release studies were performed by spectrophotometric analysis, in deionized water (20°C) and simulated gastric fluid (37°C). Different release behaviours were observed from just 10 seconds (modified starch) up to more than 24 hours (xanthan). Kinetic models such as zero‐order, first‐order, Higuchi, Korsmeyer‐Peppas, and Weibull were applied. The Weibull model showed the best fitting with the experimental data. All release tests were repeated after 4 months and showed good stability over time. A mass loss of vitamin B1 lower than 20% was detected. This study demonstrates the possibility of encapsulating vitamin B1 using different encapsulating agents by a spray‐drying technique. Depending on the intended applications, for fast release, adequate results were obtained for maltodextrin, arabic gum, modified chitosan, and sodium alginate, and for slow release, adequate results were only obtained for chitosan and pectin.

Food-Grade Microencapsulation Systems to Improve Protection of the Epigallocatechin Gallate

“…Similar morphologies were also obtained and described in the literature using these encapsulating agents but with distinct core compounds: Laurus nobilis L. extract and gallic acid [2], Elderberry Extract and rutin [43], vitamins [33,40,44] and enzymes (β-galactosidase) [45]. From all these studies described in the literature and considering the present results, it is possible to conclude that the core material (active compound) has no substantial impact on the final morphology and shape of the microparticle.…”

Biodegradable Microparticles for Regenerative Medicine: A State of the Art and Trends to Clinical Application

“…This technique provides many advantages, namely a rapid and simple process (high throughput), scalability, reproducibility, and cost-effectiveness [ 71 , 72 ]. It has also proven its suitability for the production of a wide variety of microparticle structures used as delivery carriers for various pharmacological active molecules, including proteins [ 73 , 74 ]. Manufacturing of nHA/chitosan composite microparticles via a spray-drying technique results in homogenous MPs mimicking bone structure with successfully incorporated nHA particles [ 75 ].…”

Retrospective, Perspective and Prospective of B-Complex Vitamins: Encapsulation of Vitamins and Release from Vitamin-Loaded Polymers

“…Carlan et al [90] researched microencapsulation of VB 1 into different polymers such as carrageenan, chitosan, maltodextrin, modified chitosan, modified starch, pectin, sodium alginate, and xanthan gum. The size of beads ranged from 0.11 to 1.32 μm.…”

“…The modified starch beads had VB 1 release in 10 min, while VB 1 -loaded xanthan gum had in 24 hours. The Weibull kinetic model performed the best on the experimental data [90].…”