Production of Zinc Deficiency in the Squirrel Monkey (Saimiri sciureus)

Macapinlac, M. P.; Barney, G. H.; Pearson, William N.; Darby, William J.

doi:10.1093/jn/93.4.499

Cited by 44 publications

(14 citation statements)

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“…however, may be too short to evaluate such an effect of zinc. It was studied because in various mammalian species zinc deficiency produces alterations in albumin and gamma globulin plasma levels (7,9), not unlike those found in cirrhosis of man.…”

Section: Discussionmentioning

confidence: 99%

Zinc Supplementation in Alcoholic Cirrhosis.

Weismann

Christensen

Dreyer

1979

Journal of Internal Medicine

107

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ABSTRACT. A double‐blind clinical trial with zinc sulfate, 0.2 g three times daily, and a placebo was performed in 30 patients with biopsy‐proven alcoholic liver cirrhosis. The disease was in a stable phase, and none of the patients showed evidence of a decompensated liver function. Parameters of liver function, taste acuity, dark adaptation and of zinc and vitamin A metabolism were followed for six weeks. In the zinc‐treated group of 16 patients, serum zinc rose from a normal mean value of 13.3 to 17.4 μmol/l, whereas the mean serum vitamin A level remained practically unaltered within the normal range, 1.89 at the entry and 1.83 μmol/l at the end of the study. Plasma prothrombin and serum alkaline phosphatase levels of the zinc group increased and serum bilirubin and serum carotene decreased significantly. The dark adaptation did not change, but the taste function was significantly improved during zinc treatment. The results indicate that zinc supplementation causes alleviation of certain abnormalities of cirrhotics, which deserves further attention.

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Section: Discussionmentioning

confidence: 99%

Zinc Supplementation in Alcoholic Cirrhosis.

Weismann

Christensen

Dreyer

1979

Journal of Internal Medicine

107

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“…Forty-two (45%) of all infants and children less than 4 years of age had levels of zinc in hair less than 70 ppm (Table III), including eight subjects with levels less than 30 ppm. 0.25-1 (19) 1-2 (31) 2-3 (25) 3-4 (18) 4-5 (23) 5-7 (24) 7-10 (37) AGE-YEARS 10-13 (24) 13-17 (24) 17-40…”

Section: Concentrations Of Zinc In Hairmentioning

confidence: 99%

“…Levels of zinc in hair have been demonstrated to reflect dietary intake of zinc in several animal species [24,25,29,33,43], and have been reported to provide a good index of stores of zinc in the body [47]. Low concentrations of zinc in human hair have been observed in association with zinc deficiency in the Mid East [48].…”

Section: Introductionmentioning

confidence: 99%

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Km¹,

Hambidge²,

Jacobs³

et al. 1972

Pediatr Res

579

168

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ExtractConcentrations of zinc in hair were determined for 338 apparently normal subjects living in Denver with ages ranging from 0-40 years. Mean concentrations of zinc in hair were: neonates (25) 174 db 8 (1 SEM); 3 months^-years (93) 88 ± 5; 4-17 years (132) 153 ± 5, and 17^0 years (88) 180 ±4. Ten children more than 4 years of age had levels of zinc in hair of less than 70 ppm. Seven of these ten children had a history of poor appetite and eight had heights on or below the 10th percentile; the high incidence of low growth percentiles was not explicable on a familial basis. Taste acuity was tested in six of these children, and five had evidence of obj ective hypogeusia. After supplementing the diet with small quantities of zinc, taste acuity was normalized in each of these children and levels of zinc in hair increased. Speculation

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“…As discussed, dietary levels of zinc can affect zinc concentrations in the bones of growing animals. Diets marginal or deficient in zinc have led to reduced levels in bones and various soft tissues (Flanagan 1984;Macapinlac et al 1967;Quarterman and Humphries 1983). It appears, however, that decreasing or increasing zinc intake in adult animals does not alter their zinc bone levels significantly (Cousins and Hempe 1990;Solomons 1988).…”

Section: The Status Of Zinc Relative To the Modelmentioning

confidence: 99%

Zinc as a Paleodietary Indicator: An Issue of Theoretical Validity in Bone-Chemistry Analysis

Ezzo

1994

Am. antiq.

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The use of the concentrations of zinc in archaeological bone as an indicator of past diets and/or health conditions has become widely accepted in bone-chemistry analysis, despite the fact that the theoretical validity for such an application has not been established. In this paper I present a series of critical variables—such as elemental metabolism, bone physiology, the relationship between dietary intakes of an element and its concentration in bone, trophic-level separation in the foodweb, and diagenetic variability—that must be addressed in the process of theoretical validation. I also discuss how studies that support the use of zinc as paleodietary indicator have generally focused on only one or perhaps two of these criteria. Until a sound model based on physiological principles is developed, the use of zinc as a paleodietary indicator remains unproven.

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Production of Zinc Deficiency in the Squirrel Monkey (Saimiri sciureus)

Cited by 44 publications

References 0 publications

Zinc Supplementation in Alcoholic Cirrhosis.

Zinc Supplementation in Alcoholic Cirrhosis.

Low Levels of Zinc in Hair, Anorexia, Poor Growth, and Hypogeusia in Children

Zinc as a Paleodietary Indicator: An Issue of Theoretical Validity in Bone-Chemistry Analysis

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