Production of Zn(l-Met)₂ Chelate with Improved Flowability by Reactive Crystallization

Abstract

The production of zinc l-methionine chelate (Zn­(l-Met)2) by a fed-batch reactive crystallization process was reported with enhanced flowability. Zn­(l-Met)2 chelate was obtained through the injection of an aqueous zinc salt into a high pH solution of aqueous l-Met. The total volume of aqueous zinc salt required to induce Zn­(l-Met)2 precipitation, as a function of injection rate and operating temperature, was determined by the real-time attenuated total reflection Fourier transform infrared spectroscopic analysis of a mixed suspension. The smaller this volume at the metastable limit, the larger chelate particles with a high flowability were found to be obtained. Furthermore, improved Zn­(l-Met)2 recovery was achieved upon careful selection of cation and anion species, which are not involved with Zn­(l-Met)2 precipitation in two reagent solutions, based on the salting effects. Finally, Zn­(l-Met)2 particles with excellent flowability and recovery of higher than 97% were successfully produced with a controlled injection of aqueous zinc salts at 30 °C.

Optimal density-functional theory method for zinc–amino acid complexes determined by analyzing structural and Fourier-transform infrared spectroscopy data

“…ATR-FTIR spectroscopy is typically performed to analyze a solvent in a solution; however, in the case of metal-amino acid chelates, the insoluble suspended solids are predominantly analyzied. 35 Consequently, the peak vibrational frequencies calculated for dimeric molecules reect the experimental data more accurately compared with those computed for monomeric molecules. The purpose of this study was to identify the most accurate protocol for computing the properties of two different metal complexes as polymer crystals (Fig.…”

How Structurally Similar Additives Affect the Dimensionless Interfacial Tension for Inducing Nucleation: The Case Study of Succinic Acid

“…22,23 As a probe for understanding and controlling the nucleation behavior of substances in a solution or molten state, metastable states are generally described by the width of the metastable zone (MSZW) and the induction period in the academic community. 24,25 Generally speaking, the wider the MSZW is, the greater the degree of supersaturation in the system. To obtain high-purity and uniformly distributed products in industrial production, the system needs to be controlled within the MSZW.…”