Production of155Tb for nuclear medicine in the reactions155Gd(pn),156Gd(p2n), and155Gd(d2n)

Dmitriev, P. P.; Molin, G. A.; Dmitrieva, Z. P.

doi:10.1007/bf01123521

Cited by 6 publications

(6 citation statements)

References 2 publications

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“…The integral yields are shown in Fig. 15-16 in comparison with the directly measured data (Dmitriev et al, 1982(Dmitriev et al, , 1989. The agreement with the existing experimental values for 155 T b and 156 T b is acceptable ( Fig.…”

Section: Integral Yieldssupporting

confidence: 55%

Activation cross-sections of deuteron induced reactions on natGd up to 50MeV

Tárkányi

Takács

Ditrói

et al. 2014

Applied Radiation and Isotopes

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Activation cross-sections are presented for the first time fornat Gd(d,xn) 161,160,156(m+),154,154m1,154m2,153,152(m+),151(m+) T b, nat Gd(d,x) 159,153,151 Gd and nat Gd(d,x) 156 Eu reactions from their respective thresholds up to 50 MeV. The cross-sections were measured by the stacked-foil irradiation technique and by using high resolution γ-ray spectrometry. The measured values were compared with the results of theoretical models calculated by the computer codes ALICE-D, EMPIRE-D and TALYS (data from TENDL library). Integral yields of the reaction products were deduced from the excitation functions.

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Section: Integral Yieldssupporting

confidence: 55%

Activation cross-sections of deuteron induced reactions on natGd up to 50MeV

Tárkányi

Takács

Ditrói

et al. 2014

Applied Radiation and Isotopes

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“…In agreement with the experimental cross section measurements (Dellepiane et al 2022 ; Dmitriev et al 1989 ), the (p,2n) reaction yielded higher activities compared to the (p,n) reaction. In particular, with 8 h irradiation of a [ 155 Gd]Gd 2 O 3 target, ~ 200 MBq terbium-155 was produced, while the same irradiation time on [ 156 Gd]Gd 2 O 3 targets yielded activities up to 1.7 GBq (Table 1 , Additional file 1 : Table S3).…”

Section: Resultssupporting

confidence: 88%

“…However, as expected based on previously reported investigations, the 156 Gd(p,2n) 155 Tb nuclear reaction generated higher terbium-155 activities than the 155 Gd(p,n) 155 Tb nuclear reaction (. 2021a ; Dmitriev et al 1989 ; Vermeulen et al 2012 ). A note of caution may be due here since the production yields may not be optimal: the IP2 research beamline requires degrading of the proton beam and this would result in beam spread (van der Meulen et al 2019 , 2020a ); however, the majority of the production yields were reproducible.…”

Section: Discussionmentioning

confidence: 99%

“…The thicknesses of the degraders were calculated using SRIM-2013 (Ziegler et al 2010 ). The beam energy was set to ~ 10.3 MeV for the (p,n) reaction and ~ 22.8 MeV for the (p,2n) reaction according to the cross-section measurements previously performed (Dellepiane et al 2022 ; Dmitriev et al 1989 ; Vermeulen et al 2012 ). The irradiations were performed for up to 8 h (Additional file 1 : Table S3).…”

Section: Methodsmentioning

confidence: 99%

“…Other than the spallation reactions, the production of terbium-155 is also possible by means of two proton-induced direct reactions: 155 Gd(p,n) 155 Tb and 156 Gd(p,2n) 155 Tb (Fig. 1 ) (Dmitriev et al 1989 ). The accumulation of terbium radionuclide impurities is sensibly reduced, thanks to the use of highly-enriched gadolinium oxide as target material that results in the production of high activities of terbium-155 with minimal radionuclidic contaminants (Vermeulen et al 2012 ).…”

Section: Introductionmentioning

confidence: 99%

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Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

Favaretto

Talip

Borgna

et al. 2021

EJNMMI radiopharm. chem.

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Background Terbium-155 [T1/2 = 5.32 d, Eγ = 87 keV (32%) 105 keV (25%)] is an interesting radionuclide suitable for single photon emission computed tomography (SPECT) imaging with potential application in the diagnosis of oncological disease. It shows similar decay characteristics to the clinically established indium-111 and would be a useful substitute for the diagnosis and prospective dosimetry with biomolecules that are afterwards labeled with therapeutic radiolanthanides and pseudo-radiolanthanides, such as lutetium-177 and yttrium-90. Moreover, terbium-155 could form part of the perfect “matched pair” with the therapeutic radionuclide terbium-161, making the concept of true radiotheragnostics a reality. The aim of this study was the investigation of the production of terbium-155 via the 155Gd(p,n)155Tb and 156Gd(p,2n)155Tb nuclear reactions and its subsequent purification, in order to obtain a final product in quantity and quality sufficient for preclinical application. The 156Gd(p,2n)155Tb nuclear reaction was performed with 72 MeV protons (degraded to ~ 23 MeV), while the 155Gd(p,n)155Tb reaction was degraded further to ~ 10 MeV, as well as performed at an 18 MeV medical cyclotron, to demonstrate its feasibility of production. Result The 156Gd(p,2n)155Tb nuclear reaction demonstrated higher production yields of up to 1.7 GBq, however, lower radionuclidic purity when compared to the final product (~ 200 MBq) of the 155Gd(p,n)155Tb nuclear reaction. In particular, other radioisotopes of terbium were produced as side products. The radiochemical purification of terbium-155 from the target material was developed to provide up to 1.0 GBq product in a small volume (~ 1 mL 0.05 M HCl), suitable for radiolabeling purposes. The high chemical purity of terbium-155 was proven by radiolabeling experiments at molar activities up to 100 MBq/nmol. SPECT/CT experiments were performed in tumor-bearing mice using [155Tb]Tb-DOTATOC. Conclusion This study demonstrated two possible production routes for high activities of terbium-155 using a cyclotron, indicating that the radionuclide is more accessible than the exclusive mass-separated method previously demonstrated. The developed radiochemical purification of terbium-155 from the target material yielded [155Tb]TbCl3 in high chemical purity. As a result, initial cell uptake investigations, as well as SPECT/CT in vivo studies with [155Tb]Tb-DOTATOC, were successfully performed, indicating that the chemical separation produced a product with suitable quality for preclinical studies.

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Separation of radioactive terbium from massive Gd targets for medical use

Brezovcsik

Szelecsényi

2018

J Radioanal Nucl Chem

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Production of155Tb for nuclear medicine in the reactions155Gd(pn),156Gd(p2n), and155Gd(d2n)

Cited by 6 publications

References 2 publications

Activation cross-sections of deuteron induced reactions on natGd up to 50MeV

Activation cross-sections of deuteron induced reactions on natGd up to 50MeV

Cyclotron production and radiochemical purification of terbium-155 for SPECT imaging

Separation of radioactive terbium from massive Gd targets for medical use

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