Production, physicochemical investigations, antioxidant effect, and cellular uptake in Caco-2 cells of the supersaturable astaxanthin self-microemulsifying tablets

Aung, Wai Thet; Khine, Hnin Ei Ei; Chaotham, Chatchai; Boonkanokwong, Veerakiet

doi:10.1016/j.ejps.2022.106263

Cited by 7 publications

(3 citation statements)

References 52 publications

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“…A special class of SMEDDS tablets were prepared for the effective delivery of astaxanthin. 90 To prepare astaxanthin loaded-SMEDDS a spray-dried method was adopted. The common ingredients of this SMEDDS include microcrystalline cellulose, PVA, HPMC, and other trademark polymers.…”

Section: Nanoparticle-based Tablets a Tablet Incorporating Gold Nanop...mentioning

confidence: 99%

“…The self-microemulsifying drug delivery system (SMEDDS) is considered another class of nanosystems that are often used to improve the solubility and bioavailability of therapeutic agents. , Lately, SMEDDS were also utilized for the oral administration of lipophilic drugs. , Oily droplets in SMEDDS promote stability in the gut and penetrate through mucin layers to achieve a greater oral bioavailability. A special class of SMEDDS tablets were prepared for the effective delivery of astaxanthin . To prepare astaxanthin loaded-SMEDDS a spray-dried method was adopted.…”

Section: Role Of Nanocarriers In Tabletized Nanomedicinementioning

confidence: 99%

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Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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The limitations of conventional therapeutic treatments prevailed in the development of nanotechnology-based medical formulations, termed nanomedicine. Nanomedicine is an advanced medicine that often consists of therapeutic agent(s) embedded in biodegradable or biocompatible nanomaterial-based formulations. Among nanomedicine approaches, tablet (oral) nanomedicine is still under development. In tabletized nanomedicine, the dynamic interplay between nanoformulations and the intricate milieu of the gastrointestinal tract simulates a pivotal role, particularly accentuating the influence exerted upon the luminal, mucosal, and epithelial cells. In this work, we document the perspectives and opportunities of nanoformulations toward the development of tabletized nanomedicine. This review also unveils the notion of integrating nanomedicine within a tablet formulation, which facilitates the controlled release of drugs, biomolecules, and agent(s) from the formulation to achieve a better therapeutic response. Finally, an attempt was made to explore current trends in nanomedicine technology such as bacteriophage, probiotic, and oligonucleotide tabletized nanomedicine and the combination of nanomedicine with imaging agents, i.e., nanotheranostics.

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Section: Nanoparticle-based Tablets a Tablet Incorporating Gold Nanop...mentioning

confidence: 99%

Section: Role Of Nanocarriers In Tabletized Nanomedicinementioning

confidence: 99%

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tiwari,

Kolli,

Chauhan

et al. 2024

ACS Nano

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“…Although no obvious enhancement was observed in the LBSD owing to the non-amorphous state, the pharmacokinetic study demonstrated a significant improvement in oral absorption compared to Lycovit ® due to the long-chained triglyceride for lymphatic transportation, suggesting the crystalline state did not fully affect the oral absorption in this study [ 123 ]. Aung et al [ 124 ] prepared astaxanthin-loaded SMEDDS tablets containing SMEDDS, hydrophilic polymers as precipitation inhibitors, and microcrystalline cellulose for tableting. The SMEDDS, composed of rice bran oil, Kolliphor ® RH 40, Span ® 20, and two polymers, HPMC and polyvinyl alcohol, was used to obtain the supersaturation state and enhance the release of astaxanthin.…”

Section: Approaches For the Crystalline Status Modification Of Carote...mentioning

confidence: 99%

Formulation Approaches to Crystalline Status Modification for Carotenoids: Impacts on Dissolution, Stability, Bioavailability, and Bioactivities

Liu

Hsieh

et al. 2023

Pharmaceutics

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Carotenoids, including carotenes and xanthophylls, have been identified as bioactive ingredients in foods and are considered to possess health-promoting effects. From a biopharmaceutical perspective, several physicochemical characteristics, such as scanty water solubility, restricted dissolution, and susceptibility to oxidation may influence their oral bioavailability and eventually, their effectiveness. In this review, we have summarized various formulation approaches that deal with the modification of crystalline status for carotenoids, which may improve their physicochemical properties, oral absorption, and biological effects. The mechanisms involving crystalline alteration and the typical methods for examining crystalline states in the pharmaceutical field have been included, and representative formulation approaches are introduced to unriddle the mechanisms and effects more clearly.

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Therapeutic Potential of Haematococcus pluvialis in the Field of Drug Delivery

2023

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Production, physicochemical investigations, antioxidant effect, and cellular uptake in Caco-2 cells of the supersaturable astaxanthin self-microemulsifying tablets

Cited by 7 publications

References 52 publications

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Tabletized Nanomedicine: From the Current Scenario to Developing Future Medicine

Formulation Approaches to Crystalline Status Modification for Carotenoids: Impacts on Dissolution, Stability, Bioavailability, and Bioactivities

Therapeutic Potential of Haematococcus pluvialis in the Field of Drug Delivery

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