Production, purification and formulation of nanoradiopharmaceutical with 211At: An emerging candidate for targeted alpha therapy

Ghosh, Sanchita; Banerjee, Debashis; Guleria, Apurav; Chakravarty, Rubel

doi:10.1016/j.nucmedbio.2024.108947

Nuclear Medicine and Biology

2024

DOI: 10.1016/j.nucmedbio.2024.108947

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Production, purification and formulation of nanoradiopharmaceutical with 211At: An emerging candidate for targeted alpha therapy

Sanchita Ghosh,

Debashis Banerjee,

Apurav Guleria

et al.

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2024

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Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Zhu,

Zhao,

2024

IJN

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Purpose Gold nanoparticles (Au NPs) are widely used as versatile templates to develop multifunctional nanosystems for disease diagnosis and treatment. Iodine can bind to gold via chemisorption, making this a simple method for labeling Au NPs with radioactive iodine. However, the evaluation of tumor radionuclide therapy is insufficient. In this study, we investigated the feasibility of 131 I-adsorbed Au NPs as novel nanoprobes for tumor radionuclide therapy. Materials and Methods Radiolabeling was performed by mixing Au NPs and 131 I, and the radiochemical purity (RCP) and in vitro stability of 131 I-adsorbed Au NPs were analyzed under different conditions, including various temperatures, pH values, and 131 I concentrations. The tumor accumulation and therapeutic potential of 131 I-adsorbed Au NPs were assessed using a subcutaneous tumor model after intratumoral injection. Results The data showed that the chemisorption of the Au NPs onto 131 I was instant, specific, and quantitative. The 131 I-adsorbed Au NPs exhibited high in vitro stability in different media, distinct inhibitory effects on tumor cells in vitro, good retention ability, and therapeutic effects after intratumoral injection into tumor-bearing mice in vivo. Conclusion Our work demonstrates that chemisorption of Au NPs and radioiodine has great potential as a strategy for constructing various nanosystems for theranostic applications.

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Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Zhu,

Zhao,

2024

IJN

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Production, purification and formulation of nanoradiopharmaceutical with 211At: An emerging candidate for targeted alpha therapy

Cited by 1 publication

References 43 publications

Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

Direct Labeling of Gold Nanoparticles with Iodine-131 for Tumor Radionuclide Therapy

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