Production rates and metabolic clearance rates of human follicle—stimulating hormone in premenopausal and postmenopausal women

Coble, Yank D.; Kohler, Peter O.; Cargille, Charles M.; Ross, Griff T.

doi:10.1172/jci105992

Cited by 100 publications

(37 citation statements)

References 11 publications

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“…Gastineau et al (8), using a rat ovarian hyperemia bioassay to measure serum and urinary hCG, found a value of 0.38 ml/min during normal pregnancy; using a rat prostate weight bioassay, Loraine (6) reported RCR values during pregnancy of 0.95±0.17 ml/min (SD). Midgley and Jaffe (1) found RCR values by radioimmunoassay which ranged from 0.59 to 1.75 ml/min after normal pregnancy and delivery; Johnson et al (7) Despite possessing structures which are basically similar to that of hCG, the pituitary glycoprotein hormones have MCR which are considerably greater than that of hCG (29)(30)(31)(33)(34)(35). The differences in MCR among these hormones are not necessarily attributable solely to their differences in carbohydrate composition.…”

Section: Resultsmentioning

confidence: 99%

Metabolic and renal clearance rates of purified human chorionic gonadotropin.

Wehmann¹,

Nisula²

1981

J. Clin. Invest.

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A B S T R A C T The metabolic clearance rate (MCR) and renal clearance rate (RCR) of human chorionic gonadotropin (hCG) were measured in healthy young men and women using techniques of continuous intravenous infusion and rapid intravenous injection of unlabeled, highly purified hCG. Seven subjects received 4 d of infusion at a rate of 0.2 ,ug/min, followed by an additional 4 d of infusion at 0.8 ,ug/min. Mean serum levels of hCG established at these rates of infusion were 61.1±3.3 and 237±16 ng/ml, respectively (mean ±SEM). The MCR determined at the low infusion rate was not significantly different from that determined at the higher infusion rate (1.83±0.09 vs. 1.95±0.14 ml/min per m2). The mean MCR for all subjects was 1.88±0.08 ml/min per M2. The MCR was not significantly different between men and women (2.04 ±0.13 vs. 1.76±0.07 ml/min per m2). The RCR also did not vary between low and high infusion rates (0.40±0.03 vs. 0.40±0.04 ml/min per m2). The mean RCR for all subjects was 0.40±0.02 ml/min per M2. There was no difference in RCR between men and women (0.42 ± 0.05 vs. 0.39±0.03 ml/min per m2). Six subjects were given 1.0 mg of highly purified hCG by rapid intravenous injection. Initial serum levels ofhCG were 300-400 ng/ml, and the subsequent disappearance curve was multiexponential over 8-10 d. The disappearance curve of hCG in each subject was fitted to a biexponential equation. The rapid component tl2 was 5.97±0.63 h and the slow component t1/2 was 35.6±8.0 h. We conclude that the MCR of purified hCG in man is about 2 ml/min per m2 and the RCR is 0.4 ml/min per M2; these parameters are concentration independent and do not

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Section: Resultsmentioning

confidence: 99%

Metabolic and renal clearance rates of purified human chorionic gonadotropin.

Wehmann¹,

Nisula²

1981

J. Clin. Invest.

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“…By contrast, LH and FSH are very rapidly cleared from the blood of humans (Köhler, Ross & Odell, 1968;Coble, Köhler, Cargille & Ross, 1969) and sheep (Akbar, Nett & Nis¬ wender, 1974).…”

Section: Introductionmentioning

confidence: 99%

Pregnant Mare Serum Gonadotrophin: Rate of Clearance From the Circulation of Sheep

McIntosh¹,

Moor²,

Allen³

1975

Reproduction

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“…In the present study, the constant infuThe Journal of Clinical Investigation Volume 48 1969 sion to equilibrium technique of Tait (13) was employed to assess the metabolic clearance (MCR) and production rate (PR) of HGH. This technique has also been utilized in evaluating the metabolism of other polypeptide hormones (14)(15)(16) which have been shown to have a multicompartmental distribution.…”

Section: Introductionmentioning

confidence: 99%

Metabolic clearance and production rates of human growth hormone

Taylor¹,

Finster²,

Mintz³

1969

J. Clin. Invest.

115

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A B S T R A C T The metabolic clearance rate (MCR) of human growth hormone (HGH) was determined by the constant infusion to equilibrium technique utilizing HGH-5I. 22 control subjects had a MCR of 229 ±52 ml/min (mean ±sD). No difference was evident between sexes, or between various age groups. Patients with acromegaly demonstrated normal MCR's. Moreover, acute elevations of plasma growth hormone concentrations in normal subjects did not alter the MCR of HGH. The MCR was relatively constant from day to day and within the day when subjects were evaluated in the supine position. In contrast, the assumption of the upright position was associated with a mean 24% decrease in the MCR.These results were contrasted with the MCR of HGH observed in a small number of patients with altered thyroid function or diabetes mellitus. In six patients with hypothyroidism the MCR (131 ±36 ml/min) was significantly decreased (P < 0.001); whereas the MCR in eight patients with hyperthyroidism (240 ±57 ml/min) did not differ from control subjects. The MCR in eight patients with insulin-independent diabetes mellitus (IID) (185 ±41 ml/min) and in eight patients with insulin-dependent diabetes mellitus (IDD) (136 ±31 ml/min) were significantly different from control subjects (P = < 0.05 and P = < 0.001, respectively).These data were interpreted to indicate that the plasma HGH-removing mechanism(s) is not saturated at physiologic plasma HGH of clearance from the plasma, and that the estimation of the MCR of HGH may help clarify the mechanism of abnormal plasma HGH responses to various stimuli.Production rates of HGH (PR) in control subjects (347 ±173 mug/min) were contrasted with hyperthyroid patients (529 ±242 mitg/min, P < 0.05), hypothyroid patients (160 ±69 m/g/min, P < 0.02), lID (245 ±100 m/g/min, NS), and IDD (363 ±153 mug/min, NS). Considerable variability in the determination of the concentrations of immunoprecipitable HGH-l`I and endogenous plasma HGH concentrations was encountered at apparent equilibrium conditions. Since both factors are necessary for the PR calculations, the wide 95% confidence limits of the PR's did not permit a clear interpretation of the significance of these observations. INTRODUCTION Investigators examining the physiologic regulation of plasma human growth hormone (HGH) have been aware that diverse stimuli (1-9) elicit changes in plasma HGH concentrations. Such changes in plasma levels alone, moreover, do not distinguish between the separate contributions of pituitary HGH release and HGH clearance from the plasma, both of which are responsible for a change in plasma concentration.The plasma disappearance of single intravenous injections of radioisotopically labeled HGH has been analyzed to define the distribution and turnover of HGH in humans (10-12). The fractional turnover and production rates of HGH in these studies were derived from calculations which assume first order kinetics and steadystate conditions. Some of the radioisotopic plasma disappearance curves in the literature (10, 11), however, do ...

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Production rates and metabolic clearance rates of human follicle—stimulating hormone in premenopausal and postmenopausal women

Cited by 100 publications

References 11 publications

Metabolic and renal clearance rates of purified human chorionic gonadotropin.

Metabolic and renal clearance rates of purified human chorionic gonadotropin.

Pregnant Mare Serum Gonadotrophin: Rate of Clearance From the Circulation of Sheep

Metabolic clearance and production rates of human growth hormone

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