Production-Scale Adsorptive Separations of Liquid Mixtures by Simulated Moving-Bed Technology

Broughton, D. B.

doi:10.1080/01496398408068590

Cited by 114 publications

(63 citation statements)

References 1 publication

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“…Recently, more intensive investigations have been carried out to apply the principle to more difficult separations. The SMB process is described, for example, in [3,6,7,13]. The process of annular chromatography uses a stationary phase fixed in the annular space between two concentric cylinders [8].…”

Section: Process Engineering Conceptsmentioning

confidence: 99%

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Heuer¹,

Kniep²,

Falk

et al. 1998

Chem. Eng. Technol.

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Liquid chromatography utilizing porous solid phases (adsorption chromatography) is one of the most powerful and versatile methods of modern analytical chemistry. Its widespread application is due in part to the development of a broad range of combinations of solid stationary and liquid mobile phases. Normal phase and reverse phase chromatography with pure and chemically modified silica, respectively, affinity chromatography, can be cited as examples [1]. In addition to its use as an analytical method, chromatography is becoming increasingly important in the preparative scale for the isolation of pure substances in the pharmaceutical industry, in biotechnology, and in the production of fine chemicals. In many cases, the required purity criteria can only be met with chromatographic techniques, as in the resolution of racemates. From a process engineering viewpoint, a better understanding of concentration profile deformations caused by intended overloading of separation columns has recently been acquired [2]. In particular, this concerns the description of displacement and entrainment effects associated with the competitive adsorption. A series of alternative operating modes has been developed and used [3] to enhance yields and productivities. In spite of a number of attempted comparative studies [4], quantitative information about optimizing these processes is lacking. This article will compare four different process engineering concepts of preparative chromatography on the basis of a uniform theoretical model.

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Section: Process Engineering Conceptsmentioning

confidence: 99%

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Heuer¹,

Kniep²,

Falk

et al. 1998

Chem. Eng. Technol.

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Section: The Smb Conceptmentioning

confidence: 99%

“…Adsorption processes are generally more complex than the more conventional separation techniques such as fractional distillation, solvent-aided separations, or crystallization. However, separation by adsorption can be achieved for some systems, which are either difficult or impossible to obtain by other simple methods [8,9].SMB is one of the most powerful techniques for preparative scale chromatography. The concept of SMB chromatography has been known since 1961 when the first patent by UOP (Universal Oil Products, Illinois, USA) appeared [10].…”

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confidence: 99%

Simulated Moving Bed and Related Techniques

Pais¹,

Mata²,

Rodrigues³

2005

Preparative Enantioselective Chromatography

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“…In view of these difficulties, a SMB technique was developed to retain the process advantages of continuous and countercurrent flow without introducing the problems associated with the actual movement of the solid phase. [4,14] In the SMB system, the solid phase is fixed and the positions of the inlet and outlet streams move periodically. This shift, carried out in the same direction of the liquid phase, simulates the movement of the solid phase in the opposite direction.…”

Section: Reprintsmentioning

confidence: 99%

Design of SMB Chiral Separations Using the Concept of Separation Volume

Rodrigues

Pais

2005

Separation Science and Technology

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The article deals with chiral separation by simulated moving bed (SMB) chromatography. When mass transfer resistances are negligible, equilibrium theory provides explicit criteria for the choice of the SMB operating conditions. However, in the presence of mass transfer resistances, the SMB operating conditions should be evaluated through simulation. Using a package based on the analogy with the true moving bed operation, this work shows how mass transfer resistance can affect the conditions for enantiomers separation, as well as the critical values stated by equilibrium theory. The concept of separation volume is applied to show how the flow-rate constraints, in presence of mass transfer

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Production-Scale Adsorptive Separations of Liquid Mixtures by Simulated Moving-Bed Technology

Cited by 114 publications

References 1 publication

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Comparison of Various Process Engineering Concepts of Preparative Chromatography

Simulated Moving Bed and Related Techniques

Design of SMB Chiral Separations Using the Concept of Separation Volume

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