2006
DOI: 10.1053/j.gastro.2006.08.040
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Production, Secretion, and Biological Activity of the C-Terminal Flanking Peptide of Human Progastrin

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Cited by 19 publications
(18 citation statements)
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“…No such correlation was observed between the concentrations of serum ferritin and of Gamide (data not shown). The hypergastrinemic MEN-1 patients did not show any increase in the plasma concentrations of progastrin, Ggly, or the COOH-terminal flanking peptide of progastrin (36), and hence there was no correlation between the plasma concentrations of any of these peptides and transferrin saturation. We conclude that the correlation between the circulating Gamide concentration and transferrin saturation observed in juvenile mice is also present in humans with disturbed gastrin homeostasis.…”
Section: Resultsmentioning
confidence: 84%
“…No such correlation was observed between the concentrations of serum ferritin and of Gamide (data not shown). The hypergastrinemic MEN-1 patients did not show any increase in the plasma concentrations of progastrin, Ggly, or the COOH-terminal flanking peptide of progastrin (36), and hence there was no correlation between the plasma concentrations of any of these peptides and transferrin saturation. We conclude that the correlation between the circulating Gamide concentration and transferrin saturation observed in juvenile mice is also present in humans with disturbed gastrin homeostasis.…”
Section: Resultsmentioning
confidence: 84%
“…Thus, independent secretion of carboxyamidated gastrin and glycine-extended gastrins might be expedient. Recently, the C-terminal flanking peptide has also been proposed to be bioactive (38). It might be another example of a value of differentiated secretion of progastrin-processing products.…”
Section: N-terminal Processing Begins In the Earlymentioning
confidence: 99%
“…But such release is low and does not increase the concentrations of glycine-extended gastrin in plasma [32,35]. However, using antibodies against the C-terminal flanking peptide of human progastrin [60,61], a prognostic significance of immunohistochemistry in colorectal cancers has been demonstrated [62]. The rare gastrin-producing tumor, the gastrinoma, differs from colorectal and other common cancers in which the gastrin gene is expressed.…”
Section: Clinical Significance Of Glycine-extended Hormone Precursorsmentioning
confidence: 99%