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The radioactive nuclide 225Ac is one of the few promising candidates for cancer treatment by targeted-$$\alpha$$ α -therapy, but worldwide production of 225Ac faces significant limitations. In this work, the Isotope Separation On-Line method was used to produce actinium by irradiating targets made of uranium carbide and thorium carbide with 1.4-GeV protons. Actinium fluoride molecules were formed, ionized through electron impact, then extracted and mass-separated as a beam of molecular ions. The composition of the mass-selected ion beam was verified using time-of-flight mass spectrometry, $$\alpha$$ α - and $$\gamma$$ γ -ray decay spectrometry. Extracted quantities of $$^{225}\textrm{Ac}^{19}\textrm{F}_2^{+}$$ 225 Ac 19 F 2 + particles per $$\upmu$$ μ C of incident protons were $$3.9(3)\times 10^7$$ 3.9 ( 3 ) × 10 7 from a uranium carbide target and $$4.3(4)\times 10^7$$ 4.3 ( 4 ) × 10 7 for a thorium carbide target. Using a magnetic mass separator, the long-lived contamination 227 Ac is suppressed to $$<5.47\times 10^{-7}$$ < 5.47 × 10 - 7 (95% confidence interval) with respect to 225Ac by activity. Measured rates scale to collections of 108 kBq$$\upmu$$ μ A$$^{-1}$$ - 1 h$$^{-1}$$ - 1 of directly produced $$^{225}\textrm{Ac}^{19}\textrm{F}_2^{+}$$ 225 Ac 19 F 2 + .
The radioactive nuclide 225Ac is one of the few promising candidates for cancer treatment by targeted-$$\alpha$$ α -therapy, but worldwide production of 225Ac faces significant limitations. In this work, the Isotope Separation On-Line method was used to produce actinium by irradiating targets made of uranium carbide and thorium carbide with 1.4-GeV protons. Actinium fluoride molecules were formed, ionized through electron impact, then extracted and mass-separated as a beam of molecular ions. The composition of the mass-selected ion beam was verified using time-of-flight mass spectrometry, $$\alpha$$ α - and $$\gamma$$ γ -ray decay spectrometry. Extracted quantities of $$^{225}\textrm{Ac}^{19}\textrm{F}_2^{+}$$ 225 Ac 19 F 2 + particles per $$\upmu$$ μ C of incident protons were $$3.9(3)\times 10^7$$ 3.9 ( 3 ) × 10 7 from a uranium carbide target and $$4.3(4)\times 10^7$$ 4.3 ( 4 ) × 10 7 for a thorium carbide target. Using a magnetic mass separator, the long-lived contamination 227 Ac is suppressed to $$<5.47\times 10^{-7}$$ < 5.47 × 10 - 7 (95% confidence interval) with respect to 225Ac by activity. Measured rates scale to collections of 108 kBq$$\upmu$$ μ A$$^{-1}$$ - 1 h$$^{-1}$$ - 1 of directly produced $$^{225}\textrm{Ac}^{19}\textrm{F}_2^{+}$$ 225 Ac 19 F 2 + .
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