Production Technology of Phytopreparations Based on Essential Oils

Abstract

The article provides an overview of phytopreparations technology based on essential oils, in particular: criteria for the selection of components, qualitative and quantitative compositions analyzes, parameters of the technological cycle of production of drugs, problems of standardization and quality control of stages of the production of original drugs. A number of standard samples based on terpenoids for phased quality control of the production of medicinal products are described, which are included in the European, Kazakhstan and Japanese pharmacopeias. The main countries producing essential oils and their components, as well as manufacturers of phytopreparations based on them are indicated. The modern technologies for the production of essential oils from plant materials are reviewed, namely: microwave and ultrasonic extractions, supercritical carbon dioxide extraction and micro-steam distillation with solid phase microextraction. The dosage forms of preparations based on essential oils (tablets, ointments, gels, oil solutions, suppositories, sprays, aerosols, nanocapsules), their relationship with bioavailability and therapeutic effect are discussed. Promising dosage forms that ensure dosage accuracy for the targeted action of drugs based on essential oils have been identified.

Bergamot Essential Oil: A Method for Introducing It in Solid Dosage Forms

“…Moreover, BEO has an intense fragrance and aroma, and for these reasons is widely used not only in the pharmaceutical industry, but also in the cosmetic and food industry [ 3 ]. BEO is rich in volatile compounds, such as limonene and linalool, susceptible to conversion and degradation reactions [ 4 ]. Indeed, essential oils are highly volatile, and their use is rather limited because they are photo- and thermosensitive, and have a very low water solubility.…”