The present study aimed to investigate the effect of different injection levels of selenium plus vitamin E on goat performance, intake, digestibility, nutritive value and milk and blood metabolites. Forty Baladi doe goats 2-3 year old and (20.47±1.82 kg) average live body weight were randomly divided into four groups (10 does each). The first group was a control group, does of 2 nd , 3 rd and 4 th groups received two injections of selenium and Vit. E; at early and late periods of gestation as follows, 0.125 mg Se+ 1.7 IU Vit. E/kg BW for 2 nd group (T1), 0.250 mg Se + 3.4 IU Vit. E/kg BW for 3 rd group (T2) and 0.310 mg Se + 4.2 IU Vit. E/kg BW for 4 th group (T3). Digestibility trials were carried out after each injection. Does were fed a basal ration of concentrate feed mixture and the roughage portion of the diet was Berseem hay. Body weight of dams and kids were recorded. Mineral content (Se, Zn, Fe, Mn and Cu) of serum, blood and milk parameters were determined. Results revealed that, the injection of both Se and Vit. E did not show any significant effects on TDMI and CPI of treated groups at either period of pregnancy. Control group showed higher (P<0.05) CPD% than treatments. Whereas, EED% increased with Se supplementation. Supplementation of Se and Vit. E increased TDN% at late period and decreased NB at early and late pregnancy compared to control. Supplementation increased weight gain during pregnancy. Control and T2 recorded higher (P<0.05) average weaning weight, and daily gain than T3 and T1 groups. Goats received 0.125 mg Se plus1.7 IU Vit. E (T1) produced higher milk yield followed by control, T3 and then T2. Selenium concentration in milk increased with increasing injected selenium. Higher creatinine concentration at six hours' post feeding was observed in treated groups compared with control. The highest AST was shown at zero time, while no significant effects on ALT were noticed. The highest AST value of P (5.33 mg/dl) was recorded of zero time for late pregnancy compared (3.28mg/dl) with early pregnancy periods at zero time. There were (P<0.01) differences of calcium (Ca) values among sampling time. The levels of zinc, iron did not differ significantly. Serum selenium concentration at zero time showed significant (P<0.05) differences. It could be concluded that lower level (0.125 mg Se plus 1.7 IU Vit. E/ kg /kg BW) injection of during early and late gestation improved nutrients digestibility, nutritive values, nitrogen utilization and increased milk yield of does. Moreover, injection with Selenium plus vitamin E resulted in normal renal functions (creatinine, urea), some minerals (phosphorus, calcium, iron , zinc and copper) and normal activities of both enzymes (alanine amino transferase (ALT) and aspartate amino transferase (AST) in pregnant does.