An experiment was conducted for 2 years (2018 and 2019) at Oilseed Research Farm, Kalyanpur, C. S. A. University of Agriculture and Technology, Kanpur, Uttar Pradesh, India to evaluate the effect of nutrient management practices on growth and yield of pearl millet (Pennisetum glaucum (L) R. Br. Emend. Stuntz.). Highest yield was observed in 5t FYM/ha application over control. Each unit increase in N level led to significant increase in growth, yield attributing characters and yield of pearlmillet. The maximum grain yield (24.2q/ha) was recorded with highest N level. Combined inoculation of Azospirillum + PSB increased the growth, yield attributes and yields significantly. The monetary returns were found in similar trends. Application of organic manure and bio-fertilizers resulted in desirable post-harvest soil status with more organic carbon (OC), Nitrogen (N), Phosphorus (P) and Potash (K).